mRNA Biogenesis in the Nucleus and Its Export to the Cytoplasm

Fujiwara, Naoko; Shiki, Takuya; Masuda, Seiji

doi:10.5772/35398

Cited by 3 publications

(5 citation statements)

References 140 publications

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“…This involves various extensive processing steps, and the coupling between these steps is thought to be indispensable for precise and efficient gene expression (Fujiwara, Shiki, & Masu, 2012).…”

Section: Messenger Rna (Mrna) Biogenesis: Interconnecting Processesmentioning

confidence: 99%

“…While the biogenesis of some types of RNA (snRNA) requires the transport in and out of the nucleus, others like mRNA and tRNA move exclusively in one way direction out of the nucleus. Their journeys are aided by mobile transport factors, and is mediated almost solely through the NPC (Fujiwara et al, 2012;Knockenhauer & Schwartz, 2016;. .…”

Section: Nucleo-cytoplasmic Rna Exportmentioning

confidence: 99%

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The RNA binding protein Mip6, a novel cellular partner of Mex67 export factor with implications in mRNA export

Mohamad¹

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Section: Messenger Rna (Mrna) Biogenesis: Interconnecting Processesmentioning

confidence: 99%

Section: Nucleo-cytoplasmic Rna Exportmentioning

confidence: 99%

The RNA binding protein Mip6, a novel cellular partner of Mex67 export factor with implications in mRNA export

Mohamad¹

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“…TFIIE is recruited, and recruits TFIIH. Transcription factor IIH melts the DNA at the initiation site and phosphorylates the serine-5 residue present on RNAP2, changing the pre-initiation complex from its closed into its open form (Holstege, 1997;Fujiwara, 2012;Yokoyama, 2019).…”

Section: Messenger Rnamentioning

confidence: 99%

Section: Transcription Termination and End Processingmentioning

confidence: 99%

“…Most protein-coding genes are followed by a highly conserved poly(A) signal, which functions as a transcriptional termination site and as a mechanism for post-transcriptional end processing (Fujiwara, 2012). Studies suggest that the protein complex cleavage / polyadenylation specific factor and cleavage stimulation factor are recruited to RNAP2 during the promoter binding step of transcription, and mount onto RNAP2 to identify the transcriptional termination site during transcription (Fujiwara, 2012). Cleavage and polyadenylation specificity factor forms the basis for the cleavage and polyadenylation complex, binding to the precursor-mRNA via association of its subunits WD repeat-containing protein 33 and cleavage and polyadenylation specificity factor subunit 4 to the transcriptional termination site (Neve, 2017).…”

Section: Transcription Termination and End Processingmentioning

confidence: 99%

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The Consequences of Contaminant miRNAs in Secreted Media Analysis

Thurnell

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<p><strong>This research aimed to test methods of incubation media concentration to increase detection of contaminant miRNAs, to determine if contaminant miRNAs present in incubation media were of a sufficient quantity to interfere with the secreted miRNA profile of an incubated embryo, and to characterise the associations of contaminant and embryo-derived miRNAs in terms of Ago2 protein association, and microvesicles association.</strong></p>

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Advances in Transcriptomics of Plants

Nejat

Ramalingam

Mantri

2018

Plant Genetics and Molecular Biology

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The current global population of 7.3 billion is estimated to reach 9.7 billion in the year 2050. Rapid population growth is driving up global food demand. Additionally, global climate change, environmental degradation, drought, emerging diseases, and salty soils are the current threats to global food security. In order to mitigate the adverse effects of these diverse agricultural productivity constraints and enhance crop yield and stress-tolerance in plants, we need to go beyond traditional and molecular plant breeding. The powerful new tools for genome editing, Transcription Activator-Like Effector Nucleases (TALENs) and Clustered Regulatory Interspaced Short Palindromic Repeats (CRISPR)/Cas systems (CRISPR-Cas9), have been hailed as a quantum leap forward in the development of stress-resistant plants. Plant breeding techniques, however, have several drawbacks. Hence, identification of transcriptional regulatory elements and deciphering mechanisms underlying transcriptional regulation are crucial to avoiding unintended consequences in modified crop plants, which could ultimately have negative impacts on human health. RNA splicing as an essential regulated post-transcriptional process, alternative polyadenylation as an RNA-processing mechanism, along with non-coding RNAs (microRNAs, small interfering RNAs and long non-coding RNAs) have been identified as major players in gene regulation. In this chapter, we highlight new findings on the essential roles of alternative splicing and alternative polyadenylation in plant development and response to biotic and abiotic stresses. We also discuss biogenesis and the functions of microRNAs (miRNAs) and small interfering RNAs (siRNAs) in plants and recent advances in our knowledge of the roles of miRNAs and siRNAs in plant stress response. Graphical Abstract.

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mRNA Biogenesis in the Nucleus and Its Export to the Cytoplasm

Cited by 3 publications

References 140 publications

The RNA binding protein Mip6, a novel cellular partner of Mex67 export factor with implications in mRNA export

The RNA binding protein Mip6, a novel cellular partner of Mex67 export factor with implications in mRNA export

The Consequences of Contaminant miRNAs in Secreted Media Analysis

Advances in Transcriptomics of Plants

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