MST1 Limits the Kinase Activity of Aurora B to Promote Stable Kinetochore-Microtubule Attachment

Hippo signalling in the G2/M cell cycle phase: Lessons learned from the yeast MEN and SIN pathways

“…In line with this finding, a second publication reported that MST2 signalling plays a role in chromosome alignment in metaphase [74]. Whether MST2 can also influence Aurora B activity is currently not known, but MST1 and MST2 both appear to signal through NDR1 kinase (the human counterpart of Trc in flies) [74,75]. Furthermore, they reported that NDR1 kinase activity is elevated in early mitosis [74].…”

“…However, a mitotic role for MST1/2 was described only recently [74,75]. Oh et al (2010) provided evidence suggesting that Aurora B kinase activity is regulated by MST1 signalling, thereby linking MST1 to the molecular processes of chromosome segregation in mitosis [75]. In line with this finding, a second publication reported that MST2 signalling plays a role in chromosome alignment in metaphase [74].…”

“…Taken together, these findings indicate that human MST1/2 kinases have diverse roles throughout the cell cycle. In the context of this review, the role of MST1/2 in mitosis appears to be the most interesting [74,75]. Nevertheless, in spite of these studies [74,75] and the described spindle midzone localisation of MST2 in late mitosis [82], MST1/2 signalling in mitotic exit and cytokinesis remains to be studied.…”

“…However, a mitotic role for MST1/2 was described only recently [74,75]. Oh et al (2010) provided evidence suggesting that Aurora B kinase activity is regulated by MST1 signalling, thereby linking MST1 to the molecular processes of chromosome segregation in mitosis [75].…”

KIBRA Regulates Aurora Kinase Activity and Is Required for Precise Chromosome Alignment During Mitosis

“…Interestingly, recent studies demonstrated that some other members of the Hippo pathway such as Mst1, Mst2, Mob1/Mats, and WW45 are also involved in mitotic regulation (17)(18)(19)(20)(21)(22).…”