MTA in Vital Pulp Therapy

Dammaschke, Till; Camp, Joe H.; Bogen, George

doi:10.1002/9781118892435.ch4

Cited by 12 publications

(17 citation statements)

References 164 publications

(190 reference statements)

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“…MTA is a bioactive material developed in the early 1990s, initially a retrograde filling material, that first appeared in the dental scientific literature in 1993 [ 3 ]. Recently, MTA has been used to seal exposed pulp tissue and the root canal system from surrounding tissues for various applications, such as root-end filling, perforation repair, and apexification [ 4 , 5 ]. MTA comprises a modified preparation of 70 wt % of Portland cement, the basic ingredient of concrete and mortar; 20 wt % of bismuth oxides for radiopacity; and 5 wt % of gypsum [ 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Mineral Trioxide Aggregate (MTA) Upregulates the Expression of DMP1 in Direct Pulp Capping in the Rat Molar

et al. 2021

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Mineral trioxide aggregate (MTA) is an alternative endodontic material that predicts conductive or inductive calcified tissue formation from immature pulp mesenchymal stem cells (IPMSCs). The purpose of this study was to investigate whether MTA could promote reparative odontoblast differentiation via IPMSCs in the early phase of regeneration and compare with calcium hydroxide (CH). Direct pulp capping using calcium hydroxide (CH), MTA, and MTA with platelet-rich plasma (MTA + PRP) was performed on maxillary first molars of 8-week-old male Wistar rats (n = 36). After 3, 7, or 14 days, the teeth were analyzed for mineral density (MD) and volume of MD (VMD) via micro-focusing computed tomography (µCT), nestin, dentin matrix acidic phosphoprotein 1 (DMP1) immunohistochemistry, and real-time PCR for DMP1 mRNA expression. MTA stimulated the early phase differentiation of the IPMSCs into odontoblasts, with positive results for nestin and DMP1 compared with CH. Moreover, MTA + PRP stimulated calcified granule and dentin bridge formation through calcium mineral deposition, following the induction of DMP1 mRNA expression in IPMSCs. Our results suggested that the combination of MTA and PRP is an effective and clinically applicable method for activating endogenous dental pulp stem cells into odontoblasts in the early stages of pulp regeneration.

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Section: Introductionmentioning

confidence: 99%

Mineral Trioxide Aggregate (MTA) Upregulates the Expression of DMP1 in Direct Pulp Capping in the Rat Molar

et al. 2021

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“…The quality of the hard tissue influences the state of pulpal health after direct pulp capping [30,31]. Furthermore, the formation of a hard tissue bridge does not mean that the pulp tissue will be sealed completely, because the hard tissue is permeable initially [34]. The formation of a mineralized barrier after capping with RetroMTA was reported as unpredictable, as it was incomplete and showed channels, which can be supported by the findings of this study as initial better results after 30 days compared to ProRoot MTA disappear, while the values for ProRoot MTA remain stable.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Two Different Types of Mineral Trioxide Aggregate Cements as Direct Pulp Capping Agents in Human Teeth

Ballal

Rao²,

Rao

et al. 2021

Applied Sciences

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Traumatic human dental injuries involving the pulp might necessitate direct capping procedures. This clinical study aimed to analyse the histological outcomes using two different direct capping materials. Twenty patients with bilateral premolars, scheduled for orthodontic extraction, were selected. The teeth were treated either using ProRoot MTA or RetroMTA. All patients were recalled after 30 and 60 days for teeth extraction. The histopathologically stained specimens were blindly evaluated using hard tissue bridge formation, inflammatory reaction and pulpal findings criteria. Data were evaluated statistically. Results: After 60 days, only the parameter for hard tissue bridge formation showed significant difference in the ProRoot MTA group (p = 0.010), while both direct capping materials performed similarly regarding inflammatory pulp reaction and pulpal findings. Although, during the first 30 days, RetroMTA presented better results in terms of continuity, morphology, hard tissue bridge localisation, and extension/general state of the inflammatory reaction, the continuity was better at 60 days when ProRoot MTA was applied. Treatment with RetroMTA healed the pulpal tissue faster compared with ProRoot MTA but it seemed to be rather a reparative process.

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“…Hydraulic dental cements, with their more effective biocompatibility and proven success, were recommended for use as a pulpotomy agent. MTA, a hydraulic dental cement derived from Portland cement, was first introduced by Torabinejad et al at the Loma Linda University in the 1990s 7 and its first reported use was by Lee et al in 1993. 8 As a pulpotomy agent, a preliminary report compared MTA with formocresol in 2001, wherein the teeth treated with MTA showed comparable clinical results with formocresol and higher incidence of pulp canal obliteration (PCO) after 17 months.…”

Section: Reviewmentioning

confidence: 99%

“…This is known to dissolve and remove any remnant tissue, debris or dentinal chips which can lead to infection of the radicular pulp. 7 Akcay et al compared the effects of using 5% NaOCl and physiologic saline for disinfection of the pulp chamber before placement of pulpotomy medicament in the teeth, which showed successful treatment outcomes with MTA. Of the two groups, on histologic evaluation, it was seen that only one of eight teeth in the saline group showed any inflammation, and this was minimal.…”

Section: Reviewmentioning

confidence: 99%

“… 23 To achieve this hemostasis, the use of a cotton pellet soaked with 1.25%–6% NaOCl is recommended for 1 min. 7 The NaOCl would dissolve any extrapulpal blood clot present between the wound surface and the medicament that interferes with healing. Shröder suggested that the presence of an extrapulpal blood clot potentiated the initial inflammatory response triggered by a pulpotomy medicament due to the chemotactic effect of the polymorphonuclear leukocytes of the fibrin in the clot.…”

Section: Reviewmentioning

confidence: 99%

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Mineral trioxide aggregate pulpotomy: patient selection and perspectives

Musale¹,

Kothare²,

Soni³

2018

CCIDE

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This narrative aims at reviewing the available literature for mineral trioxide aggregate (MTA) pulpotomy to understand the procedure better and eventually improve the clinical and radiographic outcomes. An electronic search was conducted in PubMed, Cochrane, ScienceDirect and ClinicalKey databases with the following keywords: MTA pulpotomy, clinical outcomes, radiographic outcomes, primary teeth. No specific inclusion or exclusion criteria were applied as to what articles would be included in this review. The time period for the search began from 2001 with respect to MTA pulpotomy. However, this was not restrictive during the search. MTA pulpotomy has been a successful treatment modality in primary molars with proven success over the years. There is limited literature to support its success in primary incisors.

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MTA in Vital Pulp Therapy

Cited by 12 publications

References 164 publications

Mineral Trioxide Aggregate (MTA) Upregulates the Expression of DMP1 in Direct Pulp Capping in the Rat Molar

Mineral Trioxide Aggregate (MTA) Upregulates the Expression of DMP1 in Direct Pulp Capping in the Rat Molar

Evaluation of Two Different Types of Mineral Trioxide Aggregate Cements as Direct Pulp Capping Agents in Human Teeth

Mineral trioxide aggregate pulpotomy: patient selection and perspectives

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