mtDNA Mutation Accumulation in Muscle Is Not a Major Cause of Fiber Loss. Reply to “Comment on: Mitochondrial Mechanisms of Neuromuscular Junction Degeneration with Aging. Cells 2020, 9, 197”

Hepple, Russell T.

doi:10.3390/cells9081821

Cells

2020

DOI: 10.3390/cells9081821

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mtDNA Mutation Accumulation in Muscle Is Not a Major Cause of Fiber Loss. Reply to “Comment on: Mitochondrial Mechanisms of Neuromuscular Junction Degeneration with Aging. Cells 2020, 9, 197”

Russell T. Hepple

Abstract: I thank you for your comment on our review paper [...]

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2023

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Interactions of mitochondrial and skeletal muscle biology in mitochondrial myopathy

Di Leo,

Bernardino Gomes,

Vincent

2023

Biochemical Journal

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Mitochondrial dysfunction in skeletal muscle fibres occurs with both healthy aging and a range of neuromuscular diseases. The impact of mitochondrial dysfunction in skeletal muscle and the way muscle fibres adapt to this dysfunction is important to understand disease mechanisms and to develop therapeutic interventions. Furthermore, interactions between mitochondrial dysfunction and skeletal muscle biology, in mitochondrial myopathy, likely have important implications for normal muscle function and physiology. In this review, we will try to give an overview of what is known to date about these interactions including metabolic remodelling, mitochondrial morphology, mitochondrial turnover, cellular processes and muscle cell structure and function. Each of these topics is at a different stage of understanding, with some being well researched and understood, and others in their infancy. Furthermore, some of what we know comes from disease models. Whilst some findings are confirmed in humans, where this is not yet the case, we must be cautious in interpreting findings in the context of human muscle and disease. Here, our goal is to discuss what is known, highlight what is unknown and give a perspective on the future direction of research in this area.

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Interactions of mitochondrial and skeletal muscle biology in mitochondrial myopathy

Di Leo,

Bernardino Gomes,

Vincent

2023

Biochemical Journal

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mtDNA Mutation Accumulation in Muscle Is Not a Major Cause of Fiber Loss. Reply to “Comment on: Mitochondrial Mechanisms of Neuromuscular Junction Degeneration with Aging. Cells 2020, 9, 197”

Abstract: I thank you for your comment on our review paper [...]

Cited by 1 publication

References 20 publications

Interactions of mitochondrial and skeletal muscle biology in mitochondrial myopathy

Interactions of mitochondrial and skeletal muscle biology in mitochondrial myopathy

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