MTHFR C677T and A1298C polymorphisms and lung cancer risk in a female Chinese population

Tong, Weiwei; Tong, Guanghui; Jin, Dong-Yan; Lv, Qingquan

doi:10.2147/cmar.s176263

Cited by 7 publications

(7 citation statements)

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“…5-methyltetrahydrofolic acid plays an important role in DNA synthesis, repair, methylation, and chromosomal integrity. Previous studies showed that the polymorphisms of 5methylenetetrahydrofolate reductase (MTHFR) gene were associated with the risk of lung cancer in the female population [36,37]. Beyond the literature, in this study, we found a significant reduction of 5methyltetrahydrofolic acid in female SCLC patients.…”

Section: Discussionsupporting

confidence: 52%

Metabolomic profiling of dried blood spots reveals gender-specific discriminant models for the diagnosis of small cell lung cancer

et al. 2020

Aging

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The accurate diagnosis of small cell lung cancer (SCLC) at initial presentation is essential to ensure appropriate treatment. No validated blood biomarkers that could distinguish SCLC from non-small cell lung cancer (NSCLC) has yet been developed. Dried blood spot (DBS) microsampling has gained increasing interest in biomarkers discovery. In this study, we first performed metabolomic profiling of DBS samples from 37 SCLC, 40 NSCLC, and 37 controls. Two gender-specific multianalyte discriminant models were established for males and females, respectively to distinguish SCLC from NSCLC and controls. The receiver operator characteristic (ROC) curve analysis showed the diagnostic accuracy of 95% (95% CI: 83%-100%) in males SCLC using five metabolites in DBS and 94% (95% CI: 74%-100%) for females using another set of five metabolites. The robustness of the models was confirmed by the random permutation tests (P < 0.01 for both). The performance of the discriminant models was further evaluated using a validation cohort with 78 subjects. The developed discriminant models yielded an accuracy of 91% and 81% for males and females, respectively, in the validation cohort. Our results highlighted the potential clinical utility of the metabolomic profiling of DBS as a convenient and effective approach for the diagnosis of SCLC.

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Section: Discussionsupporting

confidence: 52%

Metabolomic profiling of dried blood spots reveals gender-specific discriminant models for the diagnosis of small cell lung cancer

et al. 2020

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“…Then, we excluded 125 articles that were obviously irrelevant based on titles and abstracts, and the remaining 37 articles were assessed in detail for full text. After full text assessment, we eventually identified 16 [17–32] studies that could be used for the meta-analysis. A flowchart of the process used for identification of studies is presented in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…Some subsequent studies also replicated this result. [25,28,29,32] Previously, several meta-analyses were performed to evaluate the association of CMTHFR gene polymorphisms with lung cancer susceptibility. A recent meta-analysis [13] revealed that the CMTHFR C677T polymorphism is significantly associated with an increased risk of lung cancer in Asian and overall populations but not in Caucasian populations.…”

Section: Discussionmentioning

confidence: 99%

“…A recent case-control study was performed in a female Chinese population, and a significant association between the MTHFR A1298C polymorphism and a decreased risk of lung cancer was observed in Chinese women. [32] However, we failed to perform a subgroup analysis by gender due to a lack of detailed information on gender. For the meta-analysis, the CMTHFR C677T polymorphism and heterogeneity decreased after subgroup analysis in the North China population in dominant, heterozygous, homozygous and allelic genetic models; however, heterogeneity persisted in the South China population in all genetic models.…”

Section: Discussionmentioning

confidence: 99%

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Association between methylenetetrahydrofolate reductase (MTHFR) polymorphisms and lung cancer risk in Chinese people

Zhong¹,

Chen

Zhang³

et al. 2019

Medicine

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Background: The association between Methylenetetrahydrofolate Reductase (MTHFR) polymorphisms and lung cancer risk in Chinese people has been widely explored; however, the results remain controversial. Thus, we conducted a meta-analysis to investigate the association between MTHFR gene polymorphisms and susceptibility to lung cancer in Chinese people. Objective: We performed an updated meta-analysis to investigate the association between MTHFR gene polymorphisms and susceptibility to lung cancer in Chinese people. Methods: PubMed, EMBASE, WANFANG database, and CNKI were searched to collect eligible articles. The associations of MTHFR gene polymorphism with lung cancer risk were evaluated by calculating the pooled odds ratios (ORs) and the 95% confidence interval (CI). The dominant, recessive, heterozygous, homozygous, and allelic genetic models were used to calculate the combined ORs. Results: A total of 16 eligible studies were identified in the present meta-analysis. Evidence from the pooled results indicated a significant association between the MTHFR C677T polymorphism and lung cancer susceptibility in Chinese people under the dominant, recessive, homozygous and allelic genetic models (T vs C: OR = 1.252, 95% CI, 1.090–1.437; TT vs CC: OR = 1.741, 95% CI, 1.252–2.420. (TT + CT) vs CC: OR = 1.227, 95% CI, 1.030–1.426. TT vs (CT + CC): OR = 1.606, 95% CI, 1.207–2.137). Conclusion: The present updated meta-analysis demonstrated that the MTHFR C677T polymorphism was significantly associated with susceptibility to lung cancer in Chinese people. Additional case-control studies with large sample sizes are needed to validate our findings.

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“…In the Eastern Uttar Pradesh population the frequency of G allele was in the range of 58% to 70% [11][12][13]. MTHFR C677T gene polymorphism is known to be associated with predisposition for different types of cancers like-oral cancer [14], breast cancer [15,16], colorectal cancer [17,18], gastric cancer [19,20], lung cancer [21,22], pancreatic cancer [23,24], and bladder cancer [25,26]. Similarly MTRR A66G gene polymorphism is also found to be associated with various types of cancers such as-cervical cancer [27], lung cancer [28,29], meningioma [30], colorectal cancer [31,32], head and neck cancer [33], pancreatic cancer [23], and breast cancer [34].…”

Section: Introductionmentioning

confidence: 99%

Folate (MTHFRC677T andMTRRA66G) gene polymorphisms and risk of prostate cancer: a case-control study with an updated meta-analysis

Yadav

Kumar

Dwivedi

et al. 2021

Preprint

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IntroductionMethylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) are the key enzymes of the folate pathway, which involved in the DNA methylation. DNA methylation may affect the stability and integrity of DNA, that supposed to play a pivotal role in carcinogenesis. So, we aimed to investigate the association of MTHFR C677T and MTRR A66G gene polymorphisms with susceptibility to prostate cancer in North Indian population. We also performed meta-analyses of published literatures on these polymorphisms to evaluate their association with prostate cancer.MethodsWe genotyped MTHFR C677T and MTRR A66G gene polymorphisms in 147 prostate cancer cases and 147 healthy controls using PCR-RFLP methods. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated for risk estimation. For meta-analysis different databases were searched and all statistical analysis were performed using Open Meta-Analyst software.ResultsThe present case control study revealed that the T allele (OR= 1.67; 95% CI: 0.99-2.84, p= 0.05), CT genotype (OR= 1.92; 95% CI: 1.06-3.48, p= 0.02), and dominant (TT+CT) model (OR= 1.85; 95% CI: 1.05-3.30, p= 0.03) of MTHFR C677T gene polymorphism and G allele (OR= 1.92; 95% CI: 1.35-2.73, p= 0.0002) of MTRR A66G gene polymorphism were significantly associated with prostate cancer susceptibility. Meta-analyses of MTHFR C677T and MTRR A66G gene polymorphisms showed no significant association between these polymorphisms and prostate cancer risk in overall or in subgroup meta-analysis stratified by ethnicity.ConclusionMTHFR C677T and MTRR A66G gene polymorphisms seem to play a significant role in prostate cancer susceptibility in North Indian population, while results of meta-analysis revealed no association between MTHFR C677T and MTRR A66G gene polymorphisms and prostate cancer susceptibility.

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MTHFR C677T and A1298C polymorphisms and lung cancer risk in a female Chinese population

Cited by 7 publications

References 28 publications

Metabolomic profiling of dried blood spots reveals gender-specific discriminant models for the diagnosis of small cell lung cancer

Metabolomic profiling of dried blood spots reveals gender-specific discriminant models for the diagnosis of small cell lung cancer

Association between methylenetetrahydrofolate reductase (MTHFR) polymorphisms and lung cancer risk in Chinese people

Folate (MTHFRC677T andMTRRA66G) gene polymorphisms and risk of prostate cancer: a case-control study with an updated meta-analysis

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