MTHFR C677T mutation increased the risk of Ischemic Stroke, especially in large-artery atherosclerosis in adults: an updated meta-analysis from 38 researches

Cui, Tao

doi:10.3109/00207454.2014.990559

Cited by 21 publications

(14 citation statements)

References 42 publications

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“…Associations between MTHFR gene C677T and ACE I/D polymorphism and ischemic stroke have been reported in several studies . The recent results of meta‐analyses suggested that the C667T mutation was significantly associated with increased risk of ischemic stroke in adults, especially in large‐artery atherosclerosis . These results were confirmed in our study with 5/24 patients with TT and 10/24 with CT genotype and an overall mutated T allele frequency of 41.7%.…”

Section: Discussionsupporting

confidence: 88%

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Characterization of blood flow through intrapulmonary arteriovenous anastomoses and patent foramen ovale at rest and during exercise in stroke and transient ischemic attack patients

et al. 2017

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Section: Discussionsupporting

confidence: 88%

“…29,31 The recent results of meta-analyses suggested that the C667T mutation was significantly associated with increased risk of ischemic stroke in adults, especially in large-artery atherosclerosis. 32,33 These results were confirmed in our study with 5/24 patients with TT and 10/24…”

Section: Genotypingsupporting

confidence: 88%

Characterization of blood flow through intrapulmonary arteriovenous anastomoses and patent foramen ovale at rest and during exercise in stroke and transient ischemic attack patients

et al. 2017

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“…Oral contraception is also a preponderant risk factor between the young subjects; these results can be Genetically speaking, studies have suggested that MTHFR C677T variant could be a determining event of atherothrombotic IS in Morocco, which is perfectly in line with the results reported in a recent meta-analysis showing that the MTHFR C677T mutation increased the risk of IS in adulthood, particularly in atherosclerosis of large arteries [60]. The study by Diakite et al (2014) suggested a statistically significant association between G894T polymorphism of eNOS gene and IS, which is consistent with the results of a meta-analysis confirming that G894T polymorphism of eNOS gene is associated with high risk of IS among Asian populations [61].…”

Section: The Percentage Of Patients With Thrombolyzed Ischemic Strokesupporting

confidence: 86%

Ischemic stroke in Morocco: A systematic review

Kharbach

Obtel

Lahlou

et al. 2019

Preprint

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Background: The aim of this systematic review is to determine; the epidemiological and etiological profiles, the influential factors of the prehospital delay, thrombolysis management, the acute and 3-month mortality rate and the genetic aspect of ischemic stroke in Morocco.Methods: The present work is a systematic review that was conducted according to the recommendations of the "Preferred reporting items for systematic reviews and meta-analysis". We used Pubmed, Sciencedirect, Scopus, Clinicalkey, and Google scholar databases for the raking of the gray literature during the period between 2009 and 2018. The protocol of the review was registered in the PROSPERO register (CRD42018115206). These studies were analyzed based on: Age, sex ratio, risk factors, etiological profile according to Trial of ORG classification 10172 in Acute Stroke Treatment, prehospital delay average and it’s influential factors, thrombolyzed patients proportion, acute and 3-month mortality and the genetic factors of ischemic stroke in Morocco. Results: Twenty-nine (n = 29) studies were selected. The average age ranged from 49±15.2 to 67.3 ± 9.9 years old. Moreover, we reported male predominance within all ages in 13 studies. High blood pressure, diabetes, smoking and heart disease were the four identified main risk factors by these studies. Atherosclerosis and cardioembolic were the main described etiologies of cerebral ischemia, and the average prehospital time ranged from 26 to 61.9 hours. The proportion of thrombolysed patients ranged from 1.8% to 2.9%, the mortality rate varied in the acute phase from 3 to 13%, and the 3-month mortality ranged from 4.3 to 32.5%. It is also important to highlight that most of these studies have a reduced sample size, conducted in hospital environment, and no confidence interval was reported. Conclusions: Ischemic stroke is affecting more likely the young population with male predominance. Moreover, the long prehospital delay and the low proportion of thrombolysed patients are alarming. Indicating, thus, the need to investigate in depth the key factors influencing the access to care for Moroccan patients in order to improve the management of this neurologic deficit in Morocco. Key words: Ischemic stroke, Trial of ORG classification 10172 in Acute Stroke Treatment classification, prehospital delay, thrombolysis, Morocco.

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“…[5][6][7][8][9] For example, clinical studies show that atherosclerosis is closely associated with the development of stroke. [10][11][12] Individuals with risk factors for atherosclerosis, such as hypertension, hypercholesterolemia, and obesity, more often develop ischemic stroke. 9 Renal dysfunction is another proposed risk factor for cardiovascular events in patients with atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

Association between serum cystatin C levels and the severity or potential risk factors of acute ischemic stroke

Huang

Ding

et al. 2016

Neurological Research

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MTHFR C677T mutation increased the risk of Ischemic Stroke, especially in large-artery atherosclerosis in adults: an updated meta-analysis from 38 researches

Abstract: This meta-analysis suggests that MTHFR C677T mutation increased the risk of Ischemic Stroke in adults, especially in large-artery atherosclerosis.

Cited by 21 publications

References 42 publications

Characterization of blood flow through intrapulmonary arteriovenous anastomoses and patent foramen ovale at rest and during exercise in stroke and transient ischemic attack patients

Characterization of blood flow through intrapulmonary arteriovenous anastomoses and patent foramen ovale at rest and during exercise in stroke and transient ischemic attack patients

Ischemic stroke in Morocco: A systematic review

Association between serum cystatin C levels and the severity or potential risk factors of acute ischemic stroke

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