mTHPC mediated, systemic photodynamic therapy (PDT) for nonmelanoma skin cancers: Case and literature review

Horlings, Rudolf K.; Terra, Jorrit B.; Witjes, Max J. H.

doi:10.1002/lsm.22429

Cited by 21 publications

(13 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In [46], a systemic search was carried out that focused on the main clinical studies using mTHPC-PDT on non-melanoma skin cancer in humans, concluding that despite mTHPC-PDT being described in the literature as a promising and interesting therapeutic option, especially for multiple non-melanoma skin cancers, there is not enough evidence to assess this. Some studies indicate that mTHPC-PDT is a good option not as the first line of treatment but as a last resort therapy [46]. In [45], it was also noted that primary SCC lesions of the skin are amenable to PDT treatment.…”

Section: Skin Cancermentioning

confidence: 99%

Photodynamic Therapy: A Compendium of Latest Reviews

Algorri

Ochoa

Roldán-Varona

et al. 2021

Cancers

191

140

View full text Add to dashboard Cite

Photodynamic therapy (PDT) is a promising therapy against cancer. Even though it has been investigated for more than 100 years, scientific publications have grown exponentially in the last two decades. For this reason, we present a brief compendium of reviews of the last two decades classified under different topics, namely, overviews, reviews about specific cancers, and meta-analyses of photosensitisers, PDT mechanisms, dosimetry, and light sources. The key issues and main conclusions are summarized, including ways and means to improve therapy and outcomes. Due to the broad scope of this work and it being the first time that a compendium of the latest reviews has been performed for PDT, it may be of interest to a wide audience.

show abstract

Section: Skin Cancermentioning

confidence: 99%

Photodynamic Therapy: A Compendium of Latest Reviews

Algorri

Ochoa

Roldán-Varona

et al. 2021

Cancers

191

140

View full text Add to dashboard Cite

show abstract

“…Less favourable outcomes were seen at lower light intensities (51% complete clearance with 60 J/cm 2 ) [14]. Meta-tetra (hydroxyphenyl) chlorin (mTHPC) is a chlorophyll derivative, currently licensed for advanced head and neck squamous cell carcinoma (SCC) and its efficacy for NMSC remains to be determined [16]. …”

Section: Systemic Pdtmentioning

confidence: 99%

Photodynamic Therapy and Non-Melanoma Skin Cancer

Griffin

Lear

2016

Cancers

View full text Add to dashboard Cite

Non-melanoma skin cancer (NMSC) is the most common malignancy among the Caucasian population. Photodynamic therapy (PDT) is gaining popularity for the treatment of basal cell carcinoma (BCC), Bowen’s disease (BD) and actinic keratosis (AK). A topical or systemic exogenous photosensitiser, results in selective uptake by malignant cells. Protoporphyrin IX (PpIX) is produced then activated by the introduction of a light source. Daylight-mediated MAL (methyl aminolaevulinate) PDT for AKs has the advantage of decreased pain and better patient tolerance. PDT is an effective treatment for superficial BCC, BD and both individual and field treatment of AKs. Excellent cosmesis can be achieved with high patient satisfaction. Variable results have been reported for nodular BCC, with improved outcomes following pretreatment and repeated PDT cycles. The more aggressive basisquamous, morphoeic infiltrating subtypes of BCC and invasive squamous cell carcinoma (SCC) are not suitable for PDT. Prevention of “field cancerization” in organ transplant recipients on long-term immunosuppression and patients with Gorlin syndrome (naevoid basal cell carcinoma syndrome) is a promising development. The optimisation of PDT techniques with improved photosensitiser delivery to target tissues, new generation photosensitisers and novel light sources may expand the future role of PDT in NMSC management.

show abstract

“…Photodynamic therapy (PDT) achieves targeted therapy of solid tumors through local photo‐radiation of tumor cells after photosensitizer uptake, producing reactive oxygen species (ROS) and inhibiting cancer growth . PDT has been applied in multiple malignancies such as melanoma as well as head and neck, bladder, breast, and pulmonary carcinomas . This approach has benefits of limited invasion and reduced toxic effects.…”

Section: Introductionmentioning

confidence: 99%

Induction of cell death by pyropheophorbide‐α methyl ester‐mediated photodynamic therapy in lung cancer A549 cells

Huang

et al. 2017

Cancer Medicine

View full text Add to dashboard Cite

Pyropheophorbide‐α methyl ester (MPPa) was a promising photosensitizer with stable chemical structure, strong absorption, higher tissue selectivity and longer activation wavelengths. The present study investigated the effect of MPPa‐mediated photodynamic treatment on lung cancer A549 cells as well as the underlying mechanisms. Cell Counting Kit‐8 was employed for cell viability assessment. Reactive oxygen species levels were determined by fluorescence microscopy and flow cytometry. Cell morphology was evaluated by Hoechst staining and transmission electron microscopy. Mitochondrial membrane potential, cellular apoptosis and cell cycle distribution were evaluated flow‐cytometrically. The protein levels of apoptotic effectors were examined by Western blot. We found that the photocytotoxicity of MPPa showed both drug‐ and light‐ dose dependent characteristics in A549 cells. Additionally, MPPa‐PDT caused cell apoptosis by reducing mitochondrial membrane potential, increasing reactive oxygen species (ROS) production, inducing caspase‐9/caspase‐3 signaling activation as well as cell cycle arrest at G0/G1 phase. These results suggested that MPPa‐PDT mainly kills cells by apoptotic mechanisms, with overt curative effects, indicating that MPPa should be considered a potent photosensitizer for lung carcinoma treatment.

show abstract

mTHPC mediated, systemic photodynamic therapy (PDT) for nonmelanoma skin cancers: Case and literature review

Cited by 21 publications

References 39 publications

Photodynamic Therapy: A Compendium of Latest Reviews

Photodynamic Therapy: A Compendium of Latest Reviews

Photodynamic Therapy and Non-Melanoma Skin Cancer

Induction of cell death by pyropheophorbide‐α methyl ester‐mediated photodynamic therapy in lung cancer A549 cells

Contact Info

Product

Resources

About