2022
DOI: 10.1101/2022.04.19.488778
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

mTORC1 activity is essential for disease progression in chronic lymphocytic leukemia

Abstract: The precise role of mechanistic target of rapamycin complex 1 (mTORC1) during chronic lymphocytic leukemia (CLL) pathogenesis remains to be elucidated. Targeted deletion of mTORC1 component Raptor in adult mice reveals that mTORC1 function is essential for initiation and maintenance of CLL. Raptor-deficient bone marrow-derived PKCα-KR transduced haemopoietic progenitors failed to generate a CLL-like disease in vitro, due to an inability to overcome the mTORC1-mediated block in B cell lineage commitment. Induct… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 44 publications
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?