2022
DOI: 10.1101/2022.07.25.501357
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mTORC1 is required for differentiation of germline stem cells in the Drosophila melanogaster testis

Abstract: Metabolism participates in the control of stem cell function and subsequent maintenance of tissue homeostasis. How this is achieved in the context of adult stem cell niches in coordination with other local and intrinsic signaling cues is not completely understood. The Target of Rapamycin (TOR) pathway is a master regulator of metabolism and plays essential roles in stem cell maintenance and differentiation. We observe differential expression of the Tor kinase in the Drosophila male germline, which correlates w… Show more

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