MUC1 core protein as a marker of gallbladder malignancy

Ghosh, Mila; Kamma, Hiroshi; Kawamoto, Toru; Koike, Naoto; Misawa, Miwa; Kapoor, Vinay K.; Krishnani, Narendra; Agrawal, Sushma; Ohkohchi, Nobuhiro; Todoroki, Takeshi

doi:10.1016/j.ejso.2005.03.008

Cited by 33 publications

(27 citation statements)

References 10 publications

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“…9 MUC1 expression is seen in all subtypes of breast cancer, including luminal, HER2 + studies in metastatic breast, colorectal, gall bladder, non-small cell lung and gastric cancer, using KL-6, discovered that MUC1 expression at the circumference of the plasma membrane and/or in the cytoplasm frequently correlated with deep invasion, lymph node or liver metastasis and decreased five-year survival. [40][41][42][43] These studies demonstrate that MUC1 detection in patient circulation and localization of expression in the tumor are important prognostic factors for metastasis and disease progression.…”

Section: Muc1 Expression Correlates With Metastasismentioning

confidence: 99%

MUC1 and metastatic cancer

Horm

Schroeder

2013

Cell Adhesion & Migration

163

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Section: Muc1 Expression Correlates With Metastasismentioning

confidence: 99%

MUC1 and metastatic cancer

Horm

Schroeder

2013

Cell Adhesion & Migration

163

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“…High MUC1 expression was correlated with more differentiated neoplasms, whereas a high MUC4 expression was correlated with a negative nodal status (Kim et al 2012). However, a relationship between MUC1 expression and differentiation was not detected in another investigation (Ghosh et al 2005). MUC4 is preferentially expressed in the apex of cancer cells (Miyahara et al 2008).…”

Section: Ultrastructural Findingsmentioning

confidence: 95%

Adenocarcinoma of the Gallbladder (Classical Gallbladder Cancer)

Zimmermann

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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“…Transformation to malignant state results in the alteration in genes. Rate and pattern of MUC1 protein expression suggest that MUC1 would be a marker of malignant transformation of invasion of gallbladder cancer [365,366]. Prognostic value of mucin (MUC1 and MUC2) in gallbladder carcinoma along with other tumor growth factors (like p53 was carried out but Mucin expression was found to be independent of various tumor growth factors and clearly reflected the prognosis of gallbladder cancer [367].…”

Section: Gallbladder Gallbladder Inflammation and Stone Formationmentioning

confidence: 97%

Exploring the role and diversity of mucins in health and disease with special insight into non-communicable diseases

et al. 2015

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Mucins are major glycoprotein components of the mucus that coats the surfaces of cells lining the respiratory, digestive, gastrointestinal and urogenital tracts. They function to protect epithelial cells from infection, dehydration and physical or chemical injury, as well as to aid the passage of materials through a tract i.e., lubrication. They are also implicated in the pathogenesis of benign and malignant diseases of secretory epithelial cells. In Human there are two types of mucins, membrane-bound and secreted that are originated from mucous producing goblet cells localized in the epithelial cell layer or in mucous producing glands and encoded by MUC gene. Mucins belong to a heterogeneous family of high molecular weight proteins composed of a long peptidic chain with a large number of tandem repeats that form the so-called mucin domain. The molecular weight is generally high, ranging between 0.2 and 10 million Dalton and all mucins contain one or more domains which are highly glycosylated. The size and number of repeats vary between mucins and the genetic polymorphism represents number of repeats (VNTR polymorphisms), which means the size of individual mucins can differ substantially between individuals which can be used as markers. In human it is only MUC1 and MUC7 that have mucin domains with less than 40% serine and threonine which in turn could reduce number of PTS domains. Mucins can be considered as powerful two-edged sword, as its normal function protects from unwanted substances and organisms at an arm's length while, malfunction of mucus may be an important factor in human diseases. In this review we have unearthed the current status of different mucin proteins in understanding its role and function in various non-communicable diseases in human with special reference to its organ specific locations. The findings described in this review may be of direct relevance to the major research area in biomedicine with reference to mucin and mucin associated diseases.

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MUC1 core protein as a marker of gallbladder malignancy

Cited by 33 publications

References 10 publications

MUC1 and metastatic cancer

MUC1 and metastatic cancer

Adenocarcinoma of the Gallbladder (Classical Gallbladder Cancer)

Exploring the role and diversity of mucins in health and disease with special insight into non-communicable diseases

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