MUC1 Expressions and Its Prognostic Values in US Gastric Cancer Patients

Kim, Young-Il; Pecha, Robert L.; Keihanian, Tara; Mercado, Michael Oliver; Pena-Munoz, S. Valeria; Lang, Kailash; Buren, George Van; Dhingra, Sadhna; Othman, Mohamed O.

doi:10.3390/cancers15040998

Cited by 7 publications

(4 citation statements)

References 26 publications

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“…MUC1, a type of cell surface mucin that is typically expressed in the gastrointestinal tract, has been identi ed as an oncoprotein that plays a signi cant part in various stages of carcinogenesis, including tumor proliferation, metabolism, invasion, and metastasis. MUC1 is found to be signi cantly involved in the development and progression of GC, with studies revealing a strong association between elevated MUC1 expression and poor prognosis among patients a icted with this ailment [35,36]. In normal gastric tissues, MUC1 mainly protects cells through its extracellular domain, but its function is excessively changed in GC tissues.…”

Section: Discussionmentioning

confidence: 99%

Identification of the Shared Gene Signatures and Biological Mechanism in Chronic Atrophic Gastritis and Gastric cancer

Yang,

Zhang,

Fang

et al. 2023

Preprint

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Chronic atrophic gastritis (CAG), a persistent inflammatory reaction in the gastric mucosa, is considered a precursor to gastric cancer (GC). However, the specific mechanism underlying the development of GC from CAG has not been fully elucidated. Therefore, it is essential to explore the genes and pathways driving CAG progression towards GC for the prevention, diagnosis, and treatment of CAG patients. In this study, we obtained 78 common genes shared between CAG and GC through database mining. KEGG and GO functional enrichment analyses identified 21 enriched pathways and 659 GO terms associated with these 78 genes. Utilizing the protein-protein interaction (PPI) network, we identified the top five hub targets: TP53, CTNNB1, EGFR, MUC1, and CD44. mRNA and protein expression levels of these targets were found to be higher in GC tissues compared to normal tissues. Furthermore, mRNA expression levels of TP53, EGFR, and CD44 correlated with poor overall survival (OS) in GC patients. These findings offer potential therapeutic targets for further clinical and basic research.

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Section: Discussionmentioning

confidence: 99%

Identification of the Shared Gene Signatures and Biological Mechanism in Chronic Atrophic Gastritis and Gastric cancer

Yang,

Zhang,

Fang

et al. 2023

Preprint

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“…MUC1 has preservation activity and possibly contributes to cell signaling pathways related to cancer progression 76,77 . This protein is upregulated in the breast, 78 colorectal, 79,80 gastric, 81,82 lung, 83 ovarian, 84,85 prostate, 86 pancreatic, 87 and bladder cancers 77 . Likweise, Cheng et al developed a fluorescent QD‐containing DNA‐based three‐component method for selective MUC1 detection.…”

Section: Qd‐apt Conjugates For Cancer Managementmentioning

confidence: 99%

Aptamer‐functionalized quantum dots as theranostic nanotools against cancer and bacterial infections: A comprehensive overview of recent trends

Davodabadi

Mirinejad

Fathi-karkan

et al. 2023

Biotechnology Progress

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Aptamers (Apts) are synthetic nucleic acid ligands that can be engineered to target various molecules, including amino acids, proteins, and pharmaceuticals. Through a series of adsorption, recovery, and amplification steps, Apts are extracted from combinatorial libraries of synthesized nucleic acids. Using aptasensors in bioanalysis and biomedicine can be improved by combining them with nanomaterials. Moreover, Apt‐associated nanomaterials, including liposomes, polymeric, dendrimers, carbon nanomaterials, silica, nanorods, magnetic NPs, and quantum dots (QDs), have been widely used as promising nanotools in biomedicine. Following surface modifications and conjugation with appropriate functional groups, these nanomaterials can be successfully used in aptasensing. Advanced biological assays can use Apts immobilized on QD surfaces through physical interaction and chemical bonding. Accordingly, modern QD aptasensing platforms rely on interactions between QDs, Apts, and targets to detect them. QD‐Apt conjugates can be used to directly detect prostate, ovarian, colorectal, and lung cancers or simultaneously detect biomarkers associated with these malignancies. Tenascin‐C, mucin 1, prostate‐specific antigen, prostate‐specific membrane antigen, nucleolin, growth factors, and exosomes are among the cancer biomarkers that can be sensitively detected using such bioconjugates. Furthermore, Apt‐conjugated QDs have shown great potential for controlling bacterial infections such as Bacillus thuringiensis, Pseudomonas aeruginosa, Escherichia coli, Acinetobacter baumannii, Campylobacter jejuni, Staphylococcus aureus, and Salmonella typhimurium. This comprehensive review discusses recent advancements in the design of QD‐Apt bioconjugates and their applications in cancer and bacterial theranostics.

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“…In GC, MUC1 acts as an oncogene. Being overexpressed in the result of the increased abundance of chromosomal material in the GC tumor tissue, it is associated with aggressive pathological features, deeper invasion, metastasis to the lymph nodes and distant metastases [40].…”

Section: Chromosomal Rearrangements Characterizing Chromosomal Instab...mentioning

confidence: 99%

Chromosomal Instability in Gastric Cancer: Role in Tumor Development, Progression, and Therapy

Nemtsova,

Kuznetsova,

Bure

2023

IJMS

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According to the Cancer Genome Atlas (TCGA), gastric cancers are classified into four molecular subtypes: Epstein–Barr virus-positive (EBV+), tumors with microsatellite instability (MSI), tumors with chromosomal instability (CIN), and genomically stable (GS) tumors. However, the gastric cancer (GC) with chromosomal instability remains insufficiently described and does not have effective markers for molecular and histological verification and diagnosis. The CIN subtype of GC is characterized by chromosomal instability, which is manifested by an increased frequency of aneuploidies and/or structural chromosomal rearrangements in tumor cells. Structural rearrangements in the CIN subtype of GC are not accidental and are commonly detected in chromosomal loci, being abnormal because of specific structural organization. The causes of CIN are still being discussed; however, according to recent data, aberrations in the TP53 gene may cause CIN development or worsen its phenotype. Clinically, patients with the CIN subtype of GC demonstrate poor survival, but receive the maximum benefit from adjuvant chemotherapy. In the review, we consider the molecular mechanisms and possible causes of chromosomal instability in GC, the common rearrangements of chromosomal loci and their impact on the development and clinical course of the disease, as well as the driver genes, their functions, and perspectives on their targeting in the CIN subtype of GC.

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MUC1 Expressions and Its Prognostic Values in US Gastric Cancer Patients

Cited by 7 publications

References 26 publications

Identification of the Shared Gene Signatures and Biological Mechanism in Chronic Atrophic Gastritis and Gastric cancer

Identification of the Shared Gene Signatures and Biological Mechanism in Chronic Atrophic Gastritis and Gastric cancer

Aptamer‐functionalized quantum dots as theranostic nanotools against cancer and bacterial infections: A comprehensive overview of recent trends

Chromosomal Instability in Gastric Cancer: Role in Tumor Development, Progression, and Therapy

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