MUC1, MUC5AC, and MUC6 polymorphisms, Helicobacter pylori infection, and gastric cancer: a systematic review and meta-analysis

Abstract

The risk of Helicobacter pylori (HP) infection, as well as gastric cancer (GC), in association with genetic polymorphisms of gene encoding for mucins, has been investigated with contradictory results. We carried out this systematic review and meta-analysis to summarize the relationship between MUC1, MUC5AC, and MUC6 polymorphisms and HP infection, as well as GC risk. We searched MEDLINE, ISI Web of Science, Scopus bibliographic databases and the HuGE Navigator database. Odds ratios (ORs) and 95% confidence interval (CI) were calculated to assess the association between the genetic polymorphisms, and HP/GC risk. A random-effect model was used to calculate the pooled ORs, overall and by ethnicity. Twenty-one studies were included, of which five on HP and 18 on GC, of which two were in common. The meta-analysis of 10 studies on the MUC1 rs4072037 polymorphism and GC risk reported an OR of 0.66 (95% CI: 0.57-0.78) for the dominant model (AG/GG vs. AA). When stratifying for ethnicity, an OR of 0.73 (95% CI: 0.62-0.86) was reported for the Asian population and an OR of 0.48 (95% CI: 0.38-0.61) was reported for the White population. Our study confirms the protective effect of MUC1 rs4072037 polymorphism on the risk of GC under the dominant model. Further studies reporting information on HP status in cases and controls would be required to evaluate whether the protective effect of MUC1 protein might be attributable to a protective effect towards the HP infection, or through different mechanisms.

Identification of novel biomarkers, MUC5AC, MUC1, KRT7, GAPDH, CD44 for gastric cancer

“…Gastric mucosal barrier protects gastric mucosa from hydrochloric acid and various harmful substances. MUC5AC is a gel-formed mucin, which is known as the main component of the gastric mucus layer [20][21][22][23][24][25][26]. MUC5AC is a wellknown marker of gastric differentiation, which is considered to be a very important prognostic indicator of GC and is often used in clinical evaluation [27][28][29].…”

Association of MUC1 5640G>A and PSCA 5057C>T polymorphisms with the risk of gastric cancer in Northern Iran

“…MUC1 protein could work as a physical barrier and protect the gastric epithelial cells from H. pylori by inhibiting its binding to the epithelial cells. The carriers of the short-short (SS) homozygous variant genotype, were at a high risk of H. pylori infection, compared to the carriers of the long-long (LL) and long-short (LS) genotypes of MUC1 variable number of tandem repeats (VNTR) [42]. One of the previous study (Miao Li et al, 2013), tested the relation between three polymorphisms (rs4072037 at 1q22, rs13361707 at 5p13, and rs2274223 at 10q23) involved in the increase risk of gastric cancer due to the inflammatory response and H. pylori infection Table 3 Primer sequences, PCR size and PCR-RFLP fragments using AIWNI and NIaIII restriction enzymes for MUC1 5640G > A (rs4072037) and PSCA 5057C > T (rs2294008) polymorphisms, respectively [43].…”

Association ofMUC1 5640G>A and PSCA 5057C>T polymorphisms with the Risk of Gastric Cancer in Northern Iran

“…MUC1 protein could work as a physical barrier and protect the gastric epithelial cells from H. pylori by inhibiting its binding to the epithelial cells. The carriers of the short-short (SS) homozygous variant genotype, were at a high risk of H. pylori infection, compared to the carriers of the long-long (LL) and long-short (LS) genotypes of MUC1 variable number of tandem repeats (VNTR) [42]. One of the previous study (Miao Li et al, 2013), tested the relation between three polymorphisms (rs4072037 at 1q22, rs13361707 at 5p13, and rs2274223 at 10q23) involved in the increase risk of gastric cancer due to the inflammatory response and H. pylori infection [43].…”