Mucin-1 expression in endometrium is higher in polycystic ovary syndrome than in normal women

Abstract

Background<br />The polycystic ovary syndrome (PCOS) is caused by endocrine system dysfunction in women. MUCIN-1 (MUC-1) expression is found in endometrial tissues, which leads to implantation process dysfunction because of imbalance of trophoblast adhesion process. This study was conducted to compare endometrial MUC-1 expression between PCOS and normal women considering all existing external variables.<br /><br />Methods<br />This cross-sectional study was conducted in General Hospital Dr. Moewardi Surakarta. Endometrial samples were obtained from 30 infertile PCOS women based on Rotterdam criteria, and 30 normal women. Life style and reproductive data such as age, menstrual problems, menstrual cycle, age at menarche, and BMI were collected. Subjects underwent endometrial biopsy in luteinizing hormone (LH) secretion phase LH + 5 days to LH + 10 days for immunohistochemistry (IHC) of MUC-1 expression. An independent-t and multiple linear regression test were used to analyze the data at significance level of p<0.05. <br /><br />Results<br />Mean MUC-1 expression in the PCOS endometrium (49.66 ± 47.79) was significantly higher than in normal women (7.66 ± 14.55) (p=0.03). Multivariate linear regression model of life style and reproductive variables with MUC-1 showed that PCOS (b=29.54; 95% CI 9.57-49.49; p=0.004) and BMI (b= 29.99; 95% CI 5.91-54.07; p=0.001) significantly increase MUC-1 expression. PCOS (Beta=0.37) was more important than BMI (Beta=0.30) in increasing the MUC-1 expression. <br /><br />Conclusion<br />Expression of MUC-1 levels in the PCOS endometrium was higher than in normal women. This suggests that MUC-1 contributes to the unexplained reproductive failure in PCOS.

miR‐1246 is implicated as a possible candidate for endometrium remodelling facilitating implantation in buffalo (Bubalus bubalis)

“…The downregulation of MUC1 is very specific and highly localised in mice and humans which guides the blastocyst to the precise area that is considered fittest for implantation (Wilasinee et al., 2015 ). Intuitively, a higher expression of MUC1 has recently been demonstrated to lead to impaired endometrium receptivity and decidualisation in mice and women with polycystic ovarian syndrome (PCOS) (Budihastuti et al., 2020 ). Thus, our data concur with the abovementioned reports and suggest the role of TE cell‐secreted miR‐1246 in remodelling the endometrium for implantation.…”