Mucoadhesive 3D printed vaginal ovules to treat endometriosis and fibrotic uterine diseases

In this perspective, we provide a broad overview of pathophysiological processes involved in endometriosis, including the role of inflammation, fibrosis, angiogenesis, hormonal regulation, and genetic factors. For each of the functional changes involved with the etiology of the disease, we showcase a selection of active principles in various stages of preclinical and clinical development. Finally, we highlight the role of drug delivery for endometriosis, particularly oral vs. vaginal administration. In doing so, we wish to draw the community's attention to this debilitating disease and highlight the need for interdisciplinary approaches to endometriosis treatment development.

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Endometriosis, the Silent Disease: Molecular Targets, Active Principles, and Drug Delivery Systems

Teworte

Luciani

2022

Helvetica Chimica Acta

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3D printing of pharmaceutical dosage forms: Recent advances and applications

Tobias,

Felix Christofer,

Roy

et al. 2024

Advanced Drug Delivery Reviews

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Vaginal drug delivery system: A promising route of drug administration for local and systemic diseases

Subi,

Selvasudha,

Vasanthi

2024

Drug Discovery Today

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Mucoadhesive 3D printed vaginal ovules to treat endometriosis and fibrotic uterine diseases

Cited by 10 publications

References 64 publications

Endometriosis, the Silent Disease: Molecular Targets, Active Principles, and Drug Delivery Systems

Endometriosis, the Silent Disease: Molecular Targets, Active Principles, and Drug Delivery Systems

3D printing of pharmaceutical dosage forms: Recent advances and applications

Vaginal drug delivery system: A promising route of drug administration for local and systemic diseases

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