Mucoadhesive thin films for the simultaneous delivery of microbicide and anti-inflammatory drugs in the treatment of periodontal diseases

Lim, Sim Yee; Mali, Dafydd; Ong, JieJi; Ord-McDermott, Launa A; Board-Davies, Emma; Sands, Kirsty; Williams, David Wynne; Sloan, Alastair James; Heard, Charles Martin

doi:10.1016/j.ijpharm.2019.118860

Cited by 28 publications

(16 citation statements)

References 54 publications

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“…Goodson et al [ 60 , 65 ] were the first to come up with the idea of drug delivery in the periodontal pocket. They started with monolithic cellulose acetate fibers filled with tetracycline hydrochloride that was tied around the crevice of the pocket and then they proceeded to test other polymers, such as polyethylene, polypropylene, polycaprolactone, polyurethane, cellulose acetate propionate, and ethylene-vinyl acetate copolymer fibers [ 4 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 ]. The researchers have observed that in case polyethylene and polyurethane, the release of the drug was very fast.…”

Section: Drug Delivery Devicesmentioning

confidence: 99%

“…Since that time several other local drug delivery devices along with various therapeutic agents have been formulated for the effective management of periodontitis. Different types of DDS, that have been reported in recent years and a comprehensive list of all approved drugs can be found elsewhere [ 4 ]. Chitosan is also another polymer that has been investigated extensively.…”

Section: Drug Delivery Devicesmentioning

confidence: 99%

“…In a recent study, mucoadhesive thin films consisting of hydroxypropyl methylcellulose (HPMC), and low molecular weight of polyethylene glycol (PEG 400) and Carbopol 917 impregnated with microbicide and anti-inflammatory agents have shown simultaneously in situ delivery of both drugs [ 69 ]. A dental floss consisting of hydroxypropyl methylcellulose (HPMC), glycerol, polyethylene glycol 400 (PEG 400), and (polyvinylpyrrolidone-iodine as an antimicrobial agent has been reported as a potential preventive measure against periodontitis disease [ 4 ].…”

Section: Drug Delivery Devicesmentioning

confidence: 99%

“…The current treatment of periodontal disease involves oral hygiene such as mechanical cleaning (brushing and flossing), together with the use of dentifrices and antibacterial mouthwashes. Non-surgical treatment methods for periodontitis include mechanical scaling and root planning [ 4 ]. Additionally, antibiotics, especially tetracyclines, β-lactam, and nitroimidazole antibiotics are mostly used for the treatment of periodontal disease [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Polymeric Carriers for Delivery Systems in the Treatment of Chronic Periodontal Disease

et al. 2020

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Periodontitis (PD) is a chronic inflammatory disease of periodontal tissues caused by pathogenic microorganisms and characterized by disruption of the tooth-supporting structures. Conventional drug administration pathways in periodontal disease treatment have many drawbacks such as poor biodistribution, low selectivity of the therapeutic effect, burst release of the drug, and damage to healthy cells. To overcome this limitation, controlled drug delivery systems have been developed as a potential method to address oral infectious disease ailments. The use of drug delivery devices proves to be an excellent auxiliary method in improving the quality and effectiveness in periodontitis treatment, which includes inaccessible periodontal pockets. This review explores the current state of knowledge regarding the applications of various polymer-based delivery systems such as hydrogels, liposomes, micro-, and nanoparticles in the treatment of chronic periodontal disease. Furthermore, to present a more comprehensive understanding of the difficulties concerning the treatment of PD, a brief description of the mechanism and development of the disease is outlined.

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Section: Drug Delivery Devicesmentioning

confidence: 99%

Section: Drug Delivery Devicesmentioning

confidence: 99%

Section: Drug Delivery Devicesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Polymeric Carriers for Delivery Systems in the Treatment of Chronic Periodontal Disease

et al. 2020

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“…Ex vivo models such as porcine gingiva are used in some studies to evaluate anti-inflammatory effect. [23] Additional tools for FBR evaluation such as microfluidic platform were also reported: for instance, Sharifi et al developed FBR-on-a-chip (FBROC) to model the immune cell response to implants (Figure 4). The platform provides a model of the native implant microenvironment and provides a strategy to assess the FBR on various implants, in an individual and physiologically relevant manner.…”

Section: Evaluation Of Inflammatory Response To Biomaterialsmentioning

confidence: 99%

Recent Advances in Antiinflammatory Material Design

Lebaudy

Fournel

Lavalle

et al. 2020

Adv Healthcare Materials

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Implants and prostheses are widely used to replace damaged tissues or to treat various diseases. However, besides the risk of bacterial or fungal infection, an inflammatory response usually occurs. Here, recent progress in the field of anti‐inflammatory biomaterials is described. Different materials and approaches are used to decrease the inflammatory response, including hydrogels, nanoparticles, implant surface coating by polymers, and a variety of systems for anti‐inflammatory drug delivery. Complex multifunctional systems dealing with inflammation, microbial infection, bone regeneration, or angiogenesis are also described. New promising stimuli‐responsive systems, such as pH‐ and temperature‐responsive materials, are also being developed that would enable an “intelligent” antiinflammatory response when the inflammation occurs. Together, different approaches hold promise for creation of novel multifunctional smart materials allowing better implant integration and tissue regeneration.

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In vitro characterization of injectable chlorhexidine‐eluting gelatin hydrogels for local treatment of periodontal infections

Giladi

Zilberman

2022

Polymers for Advanced Techs

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Infection of the periodontal pocket presents two major challenges for drug delivery: administration into the periodontal pocket and a high fluid clearance rate in the pocket. The current study aimed to develop and study a novel gelatin-based hydrogel system crosslinked using a carbodiimide, for delivery of chlorhexidine (CHX) directly into the periodontal pocket via injection followed by in situ gelation.The study focused on the effects of the CHX concentration on its release profile and on the hydrogel's physical, mechanical, and biological properties. CHX is a common antiseptic agent and is considered as "gold standard" in dental practice.Its release profile demonstrated 39% burst release during the initial 2 h, followed by a release rate, which decreases with time for 6 days. A mathematical model based on the two-stage desorption theory was perfectly fitted to the experimental release profiles (R 2 > 0.99). Fibroblast viability results of at least 70% were achieved after 24 and 48 h, indicating that the system is biocompatible. The nonloaded and CHX-loaded hydrogels were found suitable for injectability and exhibited desired gelation times of 7.5-10.6 s, that is, compatible for filling a periodontal pocket. They exhibited excellent mechanical properties, such as burst strength (sealing ability) of 233-357 mmHg, tensile modulus of 47-69 kPa, compressive modulus of 58-104 kPa, and tensile strain of 42-113%. In conclusion, the studied CHX eluting hydrogels are of high potential to be used in minor pockets as well as deep pockets and are expected to be suitable for successfully treating a wide range of periodontal infections.

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Mucoadhesive thin films for the simultaneous delivery of microbicide and anti-inflammatory drugs in the treatment of periodontal diseases

Cited by 28 publications

References 54 publications

Polymeric Carriers for Delivery Systems in the Treatment of Chronic Periodontal Disease

Polymeric Carriers for Delivery Systems in the Treatment of Chronic Periodontal Disease

Recent Advances in Antiinflammatory Material Design

In vitro characterization of injectable chlorhexidine‐eluting gelatin hydrogels for local treatment of periodontal infections

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