Mucocele of the appendix : a case report and review of the literature

Faure, M; Salgado, Rodrigo; Beeck, Bart Op de; Bellinck, P; Termote, J L; Parizel, Paul M.

doi:10.5334/jbr-btr.87

Cited by 5 publications

(5 citation statements)

References 23 publications

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“…The clinical manifestations of perforated LAMN are more pronounced compared to non‐perforated LAMN, and although others have reported that 1/3 of patients with LAMN are asymptomatic, our study showed that the clinical manifestations include abdominal pain, bloating, abdominal discomfort, and increased abdominal girth. Many patients with mucinous appendiceal tumors are misdiagnosed as acute appendicitis, 24,25 and in our study, 27 patients were misdiagnosed preoperatively as appendicitis.…”

Section: Discussionmentioning

confidence: 51%

Long term survival outcomes of surgery combined with hyperthermic intraperitoneal chemotherapy for perforated low‐grade appendiceal mucinous neoplasms: A multicenter retrospective study

Han,

Liu,

Tian

et al. 2023

World j. surg.

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BackgroundLow‐grade appendiceal mucinous neoplasms (LAMN) are very rare, accounting for approximately 0.2%–0.5% of gastrointestinal tumors. We conducted a multicenter retrospective study to explore the impact of different surgical procedures combined with HIPEC on the short‐term outcomes and long‐term survival of patients.MethodsWe retrospectively analyzed the clinicopathological data of 91 LAMN perforation patients from 9 teaching hospitals over a 10‐year period, and divided them into HIPEC group and non‐HIPEC group based on whether or not underwent HIPEC.ResultsOf the 91 patients with LAMN, 52 were in the HIPEC group and 39 in the non‐HIPEC group. The Kaplan‐Meier method predicted that 52 patients in the HIPEC group had 5‐ and 10‐year overall survival rates of 82.7% and 76.9%, respectively, compared with predicted survival rates of 51.3% and 46.2% for the 39 patients in the non‐HIPEC group, with a statistically significant difference between the two groups (χ2 = 10.622, p = 0.001; χ2 = 10.995, p = 0.001). Compared to the 5‐year and 10‐year relapse‐free survival rates of 75.0% and 65.4% in the HIPEC group, respectively, the 5‐year and 10‐year relapse‐free survival rates of 48.7% and 46.2% in the non‐HIPEC group were significant different between the two outcomes (χ2 = 8.063, p = 0.005; χ2 = 6.775, p = 0.009). The incidence of postoperative electrolyte disturbances and hypoalbuminemia was significantly higher in the HIPEC group than in the non‐HIPEC group (p = 0.023; p = 0.044).ConclusionsThis study shows that surgery combined with HIPEC can significantly improve 5‐year and 10‐year overall survival rates and relapse‐free survival rates of LAMN perforation patients, without affecting their short‐term clinical outcomes.

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Section: Discussionmentioning

confidence: 51%

Long term survival outcomes of surgery combined with hyperthermic intraperitoneal chemotherapy for perforated low‐grade appendiceal mucinous neoplasms: A multicenter retrospective study

Han,

Liu,

Tian

et al. 2023

World j. surg.

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“…Post-operative complications include intestinal obstruction, GI bleeding, fistula formation, volvulus and PP related to iatrogenic rupture of the mucocele [20]. Thus, the vast majority of investigators support conventional surgical intervention as the treatment of choice for AM, as the tissues should be handled carefully intra-operatively.…”

Section: Methods and Resultsmentioning

confidence: 99%

Mucocele of the Appendix: Dilemmas in Differential Diagnosis and Therapeutic Management

Mastoraki¹,

Sakorafas²,

Vassiliu³

et al. 2015

Indian J Surg Oncol

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Mucocele of the appendix (AM) is a descriptive term for mucinous distension of the appendiceal lumen. It refers to the progressive retrograde dilatation of the vermiform appendix. Because of a lack of specific signs or due to its sometime quiet presentation, this condition is frequently diagnosed only at an advanced stage. We present three isolated cases of AM complicated by the development of acute inflammation of the appendix. Currently, the assessment of appendiceal lesions relies heavily on Ultra Sonography (US) as the primary diagnostic tool. This however may not always identify the origin of such a tumour. Therefore, additional investigative modalities are implemented. Despite recent research on the therapeutic strategies against appendiceal neoplastic disorders, surgical resection appears the only potentially curative approach. Accepted management includes appendectomy, right hemicolectomy, partial colectomy with debulking or palliative resection combined with additional chemotherapy. Even if laparoscopy has been successfully used to perform appendectomy, some concerns exist regarding its use in dealing with mucinous secreting lesions because of possible spillage of mucin intra-operatively. The aim of this investigation was to analyze all cases of AM complicated by the development of acute inflammation of the appendix presented in our institution. The relevant literature is briefly reviewed. Clinical features, diagnostic approach and management algorithm for appendiceal lesions are also discussed.

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“…The severest complication of the appendicular mucocele perforation is the pseudomyxoma peritonei (mucinous ascites), if there is underlying neoplastic etiology. [18,19]…”

Section: Appendicular Mucocele/low-grade Cystic Tumormentioning

confidence: 99%

Beyond the commonest: right lower quadrant abdominal pain is not always appendicitis

Agha

Sallam

Eid

2020

Alexandria Journal of Medicine

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Background: Despite acute appendicitis is the most common underlying etiology of the acute abdomen, a considerable list of other pathologies should be considered; despite sharing almost the same clinical presentation. This study aimed to re-enhance the importance and sensitivity of CT scan as a solitary imaging tool, in the evaluation of patients with acute right lower abdominal pain. Patients and methods: It is a retrospective study of the last 1000 patients, referred with acute right lower abdominal pain for CT scan examination. Biphasic CT scan abdomen protocol was applied for all. Results: Cecal carcinoma was detected in three patients (0.3%), epiploic appendicitis in five (0.5%), omental infarct in two (0.2%), appendicular mucocele in two (0.2%), appendicular NET in one (0.1%), cecal diverticulitis in four (0.4%), Chron's disease in six (0.6%), intussusception in one (0.1%) and FB in one (0.1%) and appendicular perforation in one (0.1%), acute simple appendicitis 398 (39.8%) and 577 (57.7%) were unremarkable. Conclusion: Despite acute appendicitis is the most common cause of the acute abdomen, many other surgical and non-surgical etiologies should also be considered, with a higher sensitivity of CT as a solitary diagnostic tool of imaging.

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Mucocele of the appendix : a case report and review of the literature

Cited by 5 publications

References 23 publications

Long term survival outcomes of surgery combined with hyperthermic intraperitoneal chemotherapy for perforated low‐grade appendiceal mucinous neoplasms: A multicenter retrospective study

Long term survival outcomes of surgery combined with hyperthermic intraperitoneal chemotherapy for perforated low‐grade appendiceal mucinous neoplasms: A multicenter retrospective study

Mucocele of the Appendix: Dilemmas in Differential Diagnosis and Therapeutic Management

Beyond the commonest: right lower quadrant abdominal pain is not always appendicitis

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