Mucociliary clearance – a critical upper airway host defense mechanism and methods of assessment

Antunes, Marcelo B.; Cohen, Noam A.

doi:10.1097/aci.0b013e3280114eef

Cited by 150 publications

(92 citation statements)

References 69 publications

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“…MCC is the primary physical defense of the respiratory system (57). Because NO has been previously linked to elevation of CBF (8,18,19), we examined whether Pseudomonas-conditioned medium or purified AHLs stimulated CBF in a T2R38-dependent and/or NO-dependent fashion.…”

Section: Figurementioning

confidence: 99%

T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection

Lee

Xiong²,

Kofonow³

et al. 2012

J. Clin. Invest.

500

1,003

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Innate and adaptive defense mechanisms protect the respiratory system from attack by microbes. Here, we present evidence that the bitter taste receptor T2R38 regulates the mucosal innate defense of the human upper airway. Utilizing immunofluorescent and live cell imaging techniques in polarized primary human sinonasal cells, we demonstrate that T2R38 is expressed in human upper respiratory epithelium and is activated in response to acyl-homoserine lactone quorum-sensing molecules secreted by Pseudomonas aeruginosa and other gram-negative bacteria. Receptor activation regulates calcium-dependent NO production, resulting in stimulation of mucociliary clearance and direct antibacterial effects. Moreover, common polymorphisms of the TAS2R38 gene were linked to significant differences in the ability of upper respiratory cells to clear and kill bacteria. Lastly, TAS2R38 genotype correlated with human sinonasal gram-negative bacterial infection. These data suggest that T2R38 is an upper airway sentinel in innate defense and that genetic variation contributes to individual differences in susceptibility to respiratory infection.

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Section: Figurementioning

confidence: 99%

T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection

Lee

Xiong²,

Kofonow³

et al. 2012

J. Clin. Invest.

500

1,003

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“…The airway mucosa of a healthy individual secretes mucus to eliminate foreign bodies. This is known as the mucociliary clearance mechanism [7]. However, the mucociliary clearance mechanism cannot function properly in patients with an inhalation burn injury because of mucosal damage.…”

Section: Discussionmentioning

confidence: 99%

Anesthetic management with extracorporeal membrane oxygenation in a patient with acute airway obstruction after inhalation burn injury -A case report-

et al. 2017

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“…Effective MCC requires appropriate mucus production, coordinated ciliary activity, and the mucus-cilia interaction. Cilia line the nasopharynx, middle ear, paranasal sinuses, and tracheobronchial airways; therefore, any disturbance in MCC leads to the stagnation of secretions and recurrent middle ear, sinonasal, and lower respiratory tract infections (5,(9)(10)(11) . There are two main causes of MCC impairment: impaired ciliary function or mucus structure and movement (12,13) .…”

Section: Discussionmentioning

confidence: 99%

Nasal mucociliary clearance in chronic renal failure: comparision of pre-dialysis and dialysis stages

Uluyol¹,

Alp²,

Kılıçaslan³

et al. 2016

Terh

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Objective: Chronic renal failure (CRF) is an irreversible condition that has many otorhinolaryngological manifestations. In this study we aimed to investigate the effects of CRF and haemodialysis treatment on nasal mucociliary clearance (MCC) and to explain the possible pathophysiological mechanisms. Methods: This study included 27 patients with end-stage CRF who were not undergoing haemodialysis (pre-dialysis group), 36 patients with CRF on haemodialysis (dialysis group), and 36 heathy individuals. Nasalmucociliary clearance was measured using the saccharin clearance test (SCT) and the results were statistically compared among the three groups. Results: Mean SCT times in the control, pre-dialysis, and dialysis groups were 11.7±5.7, 30.16±11.66, and 27.33±9.4 min, respectively. The results for both the predialysis and dialysis groups were significantly higher when compared with the control group (both p<0.001). There was no significant difference between the pre-dialysis and dialysis groups (p=0.22). Conclusion: Both CRF and haemodialysis treatment cause severe prolongation of MCC time. Patients with CRF should be monitored closely for middle ear, sinonasal, and respiratory tract infections and informed about potential risks of infection.

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Mucociliary clearance – a critical upper airway host defense mechanism and methods of assessment

Abstract: Advancements in techniques for analysis of mucociliary clearance have improved our understanding of the interaction between the respiratory epithelium and the airway surface liquid, resulting in the ability to study pathologic processes involving mucociliary clearance in great detail.

Cited by 150 publications

References 69 publications

T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection

T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection

Anesthetic management with extracorporeal membrane oxygenation in a patient with acute airway obstruction after inhalation burn injury -A case report-

Nasal mucociliary clearance in chronic renal failure: comparision of pre-dialysis and dialysis stages

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