2022
DOI: 10.5501/wjv.v11.i5.221
|View full text |Cite
|
Sign up to set email alerts
|

Mucosal COVID-19 vaccines: Risks, benefits and control of the pandemic

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

0
19
0
3

Year Published

2023
2023
2024
2024

Publication Types

Select...
4
3
1

Relationship

0
8

Authors

Journals

citations
Cited by 24 publications
(22 citation statements)
references
References 111 publications
0
19
0
3
Order By: Relevance
“…Furthermore, we achieved sterilizing immunity for ∆E G 68 in Syrian hamsters, a characteristic that is fundamental to preventing viral spread in humans and that has not been achieved in other vaccine candidates so far (Jung et al, 2022;Martinez-Baz et al, 2023). This might be due to enhanced local immunity after nasal application, which prevents viral shedding (Miteva et al, 2022). Interestingly, we observed transmission of high dose ΔE G 68 vaccine to one of six contact animals.…”
Section: Discussionmentioning
confidence: 81%
“…Furthermore, we achieved sterilizing immunity for ∆E G 68 in Syrian hamsters, a characteristic that is fundamental to preventing viral spread in humans and that has not been achieved in other vaccine candidates so far (Jung et al, 2022;Martinez-Baz et al, 2023). This might be due to enhanced local immunity after nasal application, which prevents viral shedding (Miteva et al, 2022). Interestingly, we observed transmission of high dose ΔE G 68 vaccine to one of six contact animals.…”
Section: Discussionmentioning
confidence: 81%
“…Although faecal IgA levels were not measured, which attributes to the activation of the mucosal immune response 10,11 , the increased level of RBD-speci c serum NAbs indicated the activation of the systemic immune system through the gastrointestinal mucosal tissues in mice. Contrasting results compared to Pogrebnyak et al 20 could be due to differences in source, size, sequence, quantity, and oral force-feeding protocol used in our study.…”
Section: Discussionmentioning
confidence: 98%
“…Presently, most commercial vaccines are parenteral and administered intramuscularly, inducing only systemic immunity [6][7][8][9] . However, for air droplet-spreading SARS-CoV-2, parenteral vaccines are less effective for the protection of viral transmission 10,11 , enabling its successful replication in the epithelial cells of the upper respiratory tract. Because of ineffective primary-entrance cell viral neutralisation by circulating IgG (NAbs), there is a risk of developing and spreading new SARAS-CoV-2 variants of concern (VOCs) 10 .…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Furthermore, we achieved sterilizing immunity for ∆E G 68 in Syrian hamsters, a characteristic that is fundamental to preventing viral spread in humans and that has not been achieved in other vaccine candidates so far 31,32 . This might be due to enhanced local immunity after nasal application, which prevents viral shedding 33 , demonstrated by a more profound immune response with ΔE G 68 virus compared to wild-type infection.…”
Section: Discussionmentioning
confidence: 99%