Mucosal Therapy for Potentially Malignant Diseases and OSCC

Svider, Peter F.; Warner, Blake M.; Schwartz, Scott J.; Garshott, Danielle M.; Weinstein, James D.; Fribley, Andrew M.

doi:10.1007/978-3-319-27647-2_12

Cited by 4 publications

(6 citation statements)

References 71 publications

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“…Site-directed chemoprevention is an alternative for managing OL since it is a low-risk and non-invasive strategy. Topical therapies have advantages, such as reducing the toxicity of chemical agents, and can be applied beyond the clinical margins of the lesions to decrease or even eliminate the risk of relapses ( 38 ).…”

Section: Current Landscape In Chemoprevention Of Oral Cancermentioning

confidence: 99%

Chemoprevention in oral leukoplakia: challenges and current landscape

Palma

Laureano

Frank

et al. 2023

Front. Oral. Health

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Oral potentially malignant disorders have the potential to transform into oral cancer. Oral leukoplakia is a prevalent OPMD with a 9.8% malignant transformation rate. The standard management for OL involves surgical excision, but its efficacy in preventing clinical recurrence and malignant transformation is limited. Therefore, alternative strategies such as chemoprevention modalities have emerged as a promising approach to inhibit the carcinogenesis process. The aim of this review was to identify human studies that investigated the effectiveness of chemopreventive agents in preventing the progression of oral leukoplakia and to provide guidance for future research. Several systemic and topical agents have been evaluated for their potential chemopreventive effects in oral leukoplakia. Systemic agents that have been investigated include vitamin A, lycopene, celecoxib, green tea extract, ZengShengPing, Bowman Birk inhibitor, beta-carotene, curcumin, erlotinib, and metformin. In addition, topical agents tested include bleomycin, isotretinoin, ONYX-015 mouthwash, ketorolac, and dried black raspberry. Despite numerous agents that have already been tested, evidence supporting their effectiveness is limited. To improve the search for an ideal chemopreventive agent for oral leukoplakia, we propose several strategies that can be implemented. Oral leukoplakia chemoprevention presents a promising opportunity for decreasing the incidence of oral cancer. Identifying new chemopreventive agents and biomarkers for predicting treatment response should be a focus of future research.

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Section: Current Landscape In Chemoprevention Of Oral Cancermentioning

confidence: 99%

Chemoprevention in oral leukoplakia: challenges and current landscape

Palma

Laureano

Frank

et al. 2023

Front. Oral. Health

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“…Furthermore, different sites in the oral cavity may show varying degree of cancerization following chronic exposure to tobacco smoke and alcohol . In such cases, it is beneficial to use both lesion/site‐specific and field‐coverage chemopreventive strategies . It is therefore reasonable to predict that multiple formulations (e.g., patches, gels, films, and injectable implants for lesion‐specific drug delivery, and oral rinse for field coverage) and chemopreventive agents, as opposed to a single system or agent, may be necessary to simultaneously treat the offending lesion and prevent the development of future lesions or recurrences.…”

Section: General Considerations In the Development Of Intraoral Drug mentioning

confidence: 99%

“…Location and characteristics of the disease Premalignant and malignant lesions arising from different sites (e.g., buccal mucosa, tongue, lips, floor of mouth, alveolar ridges, retromolar trigone, and palate) can exhibit molecular and/or histologic heterogeneity. 32,47,51,52,97 These differences have been shown to influence the progression of lesions, the diagnosis, and the therapeutic outcome. 47,51,52,97 Furthermore, different sites in the oral cavity may show varying degree of cancerization following chronic exposure to tobacco smoke and alcohol.…”

Section: General Considerations In the Development Of Intraoral Drug Delivery Systemsmentioning

confidence: 99%

“…3,32,69 In such cases, it is beneficial to use both lesion/site-specific and field-coverage chemopreventive strategies. 32,97 It is therefore reasonable to predict that multiple formulations (e.g., patches, gels, films, and injectable implants for lesion-specific drug delivery, and oral rinse for field coverage) and chemopreventive agents, as opposed to a single system or agent, may be necessary to simultaneously treat the offending lesion and prevent the development of future lesions or recurrences. Hence, it is beneficial to consider these factors when selecting the type, dose, and number of chemopreventive agents, and the delivery system.…”

Section: General Considerations In the Development Of Intraoral Drug Delivery Systemsmentioning

confidence: 99%

“…32,47,51,52,97 These differences have been shown to influence the progression of lesions, the diagnosis, and the therapeutic outcome. 47,51,52,97 Furthermore, different sites in the oral cavity may show varying degree of cancerization following chronic exposure to tobacco smoke and alcohol. 3,32,69 In such cases, it is beneficial to use both lesion/site-specific and field-coverage chemopreventive strategies.…”

Section: General Considerations In the Development Of Intraoral Drug Delivery Systemsmentioning

confidence: 99%

See 2 more Smart Citations

Polymeric drug delivery systems for intraoral site‐specific chemoprevention of oral cancer

Desai

2017

J Biomed Mater Res

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Oral cancer is among the most prevalent cancers in the world. Moreover, it is one of the major health problems and causes of death in many regions of the world. The traditional treatment modalities include surgical removal, radiation therapy, systemic chemotherapy, or a combination of these methods. In recent decades, there has been significant interest in intraoral site-specific chemoprevention via local drug delivery using polymeric systems. Because of its easy accessibility and clear visibility, the oral mucosa is amenable for local drug delivery. A variety of polymeric systems-such as gels, tablets, films, patches, injectable systems (e.g., millicylindrical implants, microparticles, and in situ-forming depots), and nanosized carriers (e.g., polymeric nanoparticles, nanofibers, polymer-drug conjugates, polymeric micelles, nanoliposomes, nanoemulsions, and polymersomes)-have been developed and evaluated for the local delivery of natural and synthetic chemopreventive agents. The findings of in vitro, ex vivo, and in vivo studies and the positive outcome of clinical trials demonstrate that intraoral site-specific drug delivery is an attractive, highly effective and patient-friendly strategy for the management of oral cancer. Intraoral site-specific drug delivery provides unique therapeutic advantages when compared to systemic chemotherapy. Moreover, intraoral drug delivery systems are self-administrable and can be removed when needed, increasing patient compliance. This article covers important aspects and advances related to the design, development, and efficacy of polymeric systems for intraoral site-specific drug delivery. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1383-1413, 2018.

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