Mucosal tissue polyclonal IgE is functional in response to allergen and SEB

Zhang, Nan; Holtappels, Gabriële; Gevaert, Philippe; Patou, Joke; Dhaliwal, B.; Gould, Hannah; Bachert, Claus

doi:10.1111/j.1398-9995.2010.02448.x

Cited by 180 publications

(165 citation statements)

References 19 publications

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“…Interestingly, this polyclonal IgE from mucosal tissue appears to be functional, and may induce mast cell degranulation to numerous inhalant allergens. Together with the fact that SEB may serve as an allergen, these findings may contribute to persistent inflammation by continuously activating mast cells [60]. These findings confirm the role played by S. aureus enterotoxins as disease modifiers in CRSwNP [61,62].…”

Section: Role Of Staphylococcal Enterotoxins In Airway Diseasesupporting

confidence: 69%

Role of Staphylococcal Superantigens in Airway Disease

Huvenne

Hellings

Bachert

2013

Int Arch Allergy Immunol

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Staphylococcus aureus is a common human pathogen, which is regularly part of the normal microflora found in the nose and skin. It represents a significant threat to human health, not in the least because of its capability to produce exotoxins, which have superantigenic properties. These exotoxins, in particular the staphylococcal enterotoxins (SEs), are known to be involved in the modulation and aggravation of airway inflammation. Indeed, recent studies show an important impact of SEs on the natural course of allergic rhinitis, nasal polyposis, asthma and COPD. This review outlines the current knowledge on the influence of SEs on airway inflammation. We highlight, in particular, the recent evidence on their role in asthma.

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Section: Role Of Staphylococcal Enterotoxins In Airway Diseasesupporting

confidence: 69%

Role of Staphylococcal Superantigens in Airway Disease

Huvenne

Hellings

Bachert

2013

Int Arch Allergy Immunol

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“…The locally formed IgE is polyclonal, with IgE antibodies against several hundred or more allergens, and functional, even in the absence of systemic IgE antibodies or a positive skin-prick test. 916,917 Among those IgE specificities, only staphylococcal enterotoxins have superantigenic activity. CRSwNP showed a significantly higher S. aureus culture-positivity and a higher detection rate of S. aureus superantigens and of specific SE-IgE in a recent meta-analysis.…”

Section: Viiib Crswnp: Comorbid Asthmamentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

558

888

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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“…Staphylococcal superantigens (SAg) have recently been implicated in the pathogenesis of various allergic conditions, e.g. atopic dermatitis, urticaria, allergic rhinitis, nasal polyposis and bronchial asthma [5,6,7,8]. Previous studies have reported that the prevalence of serum-specific immunoglobulin E (IgE) to SAg is related to the severity of asthma and eosinophilic inflammation in adult asthma [9,10,11].…”

Section: Introductionmentioning

confidence: 99%

Clinical Significance of Immunoglobulin E Responses to Staphylococcal Superantigens in Patients with Aspirin-Exacerbated Respiratory Disease

Yoo¹,

Shin²,

Liu³

et al. 2013

Int Arch Allergy Immunol

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Background: Previous studies have reported a higher prevalence of immunoglobulin E (IgE) specific for staphylococcal superantigens (SAg) in the nasal mucosa of patients with aspirin-exacerbated respiratory disease (AERD), associated with eosinophilic inflammation and leukotriene production. However, the role of SAg-specific IgE in the pathogenesis of AERD is not well understood. We evaluated the clinical significance of serum IgE specific for three types of SAg, namely staphylococcal enterotoxins A and B (SEA and SEB) and toxic shock syndrome toxin-1 (TSST-1) in AERD. Methods: We enrolled 147 patients with AERD confirmed by a lysine-acetyl salicylic acid bronchoprovocative test and compared them with 147 patients with aspirin-tolerant asthma (ATA) and 141 healthy controls (NC). The levels of serum total IgE and SAg-specific IgE were measured using an ImmunoCAP system. Other clinical parameters were analyzed retrospectively. Results: The prevalences of SEA-, SEB- and TSST-1-specific IgE in the AERD and ATA groups were significantly higher than those in the NC group (p < 0.05, respectively). The total IgE level was significantly higher in patients with AERD with high levels of SEA-specific IgE than in those with lower levels (p < 0.05), with significant positive correlations between total and SAE-specific IgE levels (p < 0.05). The PC₂₀ methacholine level was significantly lower in patients with AERD with high levels of SEA-specific IgE, while a significantly higher eosinophil count was noted in patients with AERD with high levels of SEB-specific IgE (p < 0.05, respectively). Conclusions: Specific IgE responses to SAg may increase the serum total IgE level, airway hyperresponsiveness and eosinophil activation, leading to more severe clinical symptoms in AERD.

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Mucosal tissue polyclonal IgE is functional in response to allergen and SEB

Cited by 180 publications

References 19 publications

Role of Staphylococcal Superantigens in Airway Disease

Role of Staphylococcal Superantigens in Airway Disease

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Clinical Significance of Immunoglobulin E Responses to Staphylococcal Superantigens in Patients with Aspirin-Exacerbated Respiratory Disease

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