Mulberry extract inhibits the development of atherosclerosis in cholesterol-fed rabbits

Chen, Chang-Che; Liu, Li-Kaung; Hsu, Jeng-Dong; Huang, Hui-Pei; Yang, Mon-Yuan; Wang, Chau‐Jong

doi:10.1016/j.foodchem.2004.06.039

Cited by 118 publications

(88 citation statements)

References 24 publications

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“…Such effect has been demonstrated in experiments using M. alba root bark or fruit (Chen et al, 2005;El-Bebshbishy et al, 2006) and in other plants (Chan et al, 1999;Wang et al, 2000;Yeh et al, 2003).…”

Section: Resultsmentioning

confidence: 74%

Hypotriglyceridemic effect of Morus alba L., Moraceae, leaves in hyperlipidemic rats

Zeni¹,

Dall'Molin²

2010

Rev. bras. farmacogn.

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RESUMO: "Efeito hipotrigliceridêmico de folhas de Morus alba L., Moraceae, em ratos hiperlipidêmicos". As folhas de amoreira branca Morus alba L., Moraceae, são utilizadas no Brasil na medicina popular para tratar febre, como protetor do fígado, para baixar a pressão e o colesterol. O extrato aquoso de folhas de M. alba foi administrado via oral através de gavagem em ratos hiperlipidêmicos com uma dieta enriquecida com colesterol (1%) com uma dose de 150 mg/kg/dia por quatorze dias que reduziu significativamente em 55,01% o nível de triglicerídios plasmáticos. Desta forma, o tratamento diminuiu o nível de triglicerídios e uma enzima hepática testada, demonstrando que extratos de Morus alba que tem sido popularmente utilizados possuem um grande potencial para se tornar um fitomedicamento. Unitermos: Morus alba, ratos hiperlipidêmicos, triglicerídios.ABSTRACT: Mulberry Morus alba L., Moraceae, leaves are used in Brazil medicines against fever, to protect the liver, to lower the blood pressure and cholesterol. The aqueous extract of leaves of M. alba given by oral route to hyperlipidemic rats with diet enriched by cholesterol (1% by weight) with dose of 150 mg/kg/day for forteen days reduced significantly by 55,01% the plasma triglycerides level. Therefore, the treatment not only decreased the plasma level of triglycerides but also affected a hepatic enzyme tested supportting the fact that the extracts of Morus alba that have been used by folk medicine have a great potential to be further developed into a phytomedicine.

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Section: Resultsmentioning

confidence: 74%

Hypotriglyceridemic effect of Morus alba L., Moraceae, leaves in hyperlipidemic rats

Zeni¹,

Dall'Molin²

2010

Rev. bras. farmacogn.

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“…These occur as cyanidin-3-glucoside and cyanidin-3-rutinoside (Suh et al 2004;Chen et al 2006;Lin & Tang 2007). As a traditional Chinese edible fruit, mulberry fruit is used effectively in folk medicine to treat fever, protect the liver from damage, strengthen the joints, facilitate the discharge of urine, and lower the blood pressure (Yang 1998;Jia et al 1999;Chen et al 2005Chen et al , 2006Bae & Suh 2007). Mulberry fruit has been consumed broadly as a health-protective fruit in recent times.…”

mentioning

confidence: 99%

Separation and character analysis of anthocyanins from mulberry (Morus alba L.) pomace

Zhang¹,

He²,

QiuHong³

et al. 2011

Czech J. Food Sci.

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Zhang W., He J., Pan Q., Han F., Duan C. (2011): Separation and character analysis of anthocyanins from mulberry (Morus alba L.) pomace. Czech J. Food Sci., 29: 268-276.Mulberry pomace, as a by-product of juice and wine making, was investigated as a potential source of natural anthocyanins. The results showed that anthocyanin contents in mulberry pomace from two varieties were above 250 mg/100 g, that is 74%-79% of that in mulberry whole fruit. Thus, mulberry pomace could be a potential anthocyanins source. The anthocyanins in mulberry pomace had an attractive red colour with the chroma at 5.0 and hue angle at 6.8. Five anthocyanins were identified in mulberry pomace, cyanidin-3-glucoside and cyanidin-3-rutinoside being the major anthocyanins. The method of the separation of the two anthocyanins was studied showing that both anthocyanins with purities above 98% could be well separated on Sephadex LH-20 by eluting with 10% ethanol containing 1% of acetic acid after purification with AB-8 macroporous resin. The recovery of the complete process of both anthocyanins was 57.4%. Cyanidin-3-glucoside and cyanidin-3-rutinoside had more attractive colours and strong antioxidant activities and could be used as potential food colourants and antioxidants.

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“…The major anthocyanins identified in the fruit extract are cyanidin 3-glucoside and cyanidin 3-rutinoside (Suh et al, 2003). Recently, mulberry fruit has been reported to possess medicinal benefit, such as potent anti-oxidant activity (Chen et al, 2005;Kang et al, 2006), anti-inflammation (Shin et al, 2006), anti-thrombotic (Allen and Bayraktutan, 2009). Moreover, mulberry exhibit inhibitory effect on the migration and invasion of a human lung cancer cell line (Chen et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…Recently, mulberry fruit has been reported to possess medicinal benefit, such as potent anti-oxidant activity (Chen et al, 2005;Kang et al, 2006), anti-inflammation (Shin et al, 2006), anti-thrombotic (Allen and Bayraktutan, 2009). Moreover, mulberry exhibit inhibitory effect on the migration and invasion of a human lung cancer cell line (Chen et al, 2005). Therefore, exploring the diverse bioactivities of this extract can be exploited pharmacologically resulting to candidate for decreasing the aliments associated with stroke.…”

Section: Discussionmentioning

confidence: 99%

Mulberry Fruits Extract Mitigate Vascular Dementia

Baljit¹

2012

American Journal of Applied Sciences

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To date, Vascular Dementia (VaD) is the second most commonly found dementia following Alzheimer's disease. Though VaD is still increasing its importance, the therapeutic efficacy is still not in satisfaction level. Therefore, the searching for an acceptable cheap and safe neuroprotective agent is in a great demand. Based on the neuroprotective and cognitive enhancing effects in alcohol neurotoxicity of mulberry fruits, we hypothesized that mulberry fruits might attenuate memory impairment and brain damage in vascular dementia. Therefore, this study was set up to determine the effects and possible mechanism of actions of mulberry fruits. Male Wistar rats had been orally given mulberry fruits at doses of 2,10 and 50 mg.kg -1 BW for 7 days before and 21 days after the occlusion of right Middle Cerebral Artery (Rt. MCAO). Rats were evaluated spatial memory using Morris water maze every 7 days after Rt.MCAO throughout 21-day experimental period, then they were sacrificed for determined the density of cholinergic neuron in hippocampus and determine acetyl cholinesterase (AChE) enzyme, a key enzyme indicating Acetylcholine (ACh) turnover in hippocampus and assessment of brain infarction volume The results show that the mulberry fruits extract significantly improved memory performance in Morris water maze test, number of cholinergic neurons and decrease the level of acetyl cholinesterase activity. The mulberry fruit extract is the potential neuroprotective agent and cognitive enhancing fruits. However, further researches are required identify the possible active ingredient and precise underlying mechanism.

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Mulberry extract inhibits the development of atherosclerosis in cholesterol-fed rabbits

Cited by 118 publications

References 24 publications

Hypotriglyceridemic effect of Morus alba L., Moraceae, leaves in hyperlipidemic rats

Hypotriglyceridemic effect of Morus alba L., Moraceae, leaves in hyperlipidemic rats

Separation and character analysis of anthocyanins from mulberry (Morus alba L.) pomace

Mulberry Fruits Extract Mitigate Vascular Dementia

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