Mulberry leaf attenuates atherosclerotic lesions in patients with coronary heart disease possibly via 1‐Deoxynojirimycin: A placebo‐controlled, double‐blind clinical trial

Abstract

Coronary heart disease (CHD) refers to coronary atherosclerosis, which causes vascular stenosis or obstruction. Because of its high mortality and disability rate, it seriously endangers human life (Lee et al., 2018; Zannad et al., 2018). A large number of clinical research data show that the risk factors are associated with CHD development, including blood pressure (BP), lipid disorders, abnormal

Phytochemical characterization ofMorus nigrafruit ultrasound‐assisted ethanolic extract for its cardioprotective potential

“…An increase in ROS on exposure to cigarette smoke and a high‐fat diet was observed (Lee, Lee, et al, 2019; Suryadinata & Wirjatmadi, 2021). Contrastingly, mulberry polyphenol, 1‐DNJ improved the antioxidant enzymes in coronary heart patients (Y. Wang et al, 2021). A significant decline in lipotoxicity via moderating the ROS production, GSH‐Px content, and mitochondrial dysfunction after treatment with mulberry digest (Hu et al, 2018).…”

“…Anthocyanin‐rich mulberry leaf jelly improves the serum lipid profile in dyslipidemic subjects (On‐Nom et al, 2020). In vivo administration of 1‐DNJ effectively reduces the lipid profile, inflammation, and carotid intima‐media thickness in coronary heart patients (Wang et al, 2021). Furthermore, upregulation of genes involved in bile acid and hepatic synthesis (Lee, Lee, et al, 2020).…”

“…An increase in ROS on exposure to cigarette smoke and a high-fat diet was observedSuryadinata & Wirjatmadi, 2021). Contrastingly, mulberry polyphenol, 1-DNJ improved the antioxidant enzymes in coronary heart patients (Y Wang et al, 2021)…”

Mulberry Leaf Supplements Effecting Anti-Inflammatory Genes and Improving Obesity in Elderly Overweight Dogs

“…A study reported that high-dose 1-deoxynojirimycin (1-DNJ), which is found to be distributed among the mulberry species, reduces aspartate transferase (AST) and alanine transferase (ALT) levels, and increases sensitivity to fat in high-fat mice [ 12 , 13 ]. The 1-DNJ significantly reduces intestinal glucose absorption [ 14 ], improves the serum lipid profile in coronary heart disease [ 15 ], inhibits metastasis of melanoma cells [ 16 ], and improves insulin sensitivity [ 17 ]. In addition, the effects of mulberry leaf on both humoral and cellular immunity have been proven by increasing antibody production levels during in vitro and in vivo experiments [ 18 , 19 ].…”

Mulberry polyphenols ameliorate atherogenic migration and proliferation by degradation of K-Ras and downregulation of its signals in vascular smooth muscle cell

“…Mulberry leaf tea and it major ingredient deoxynojirimycin significantly repressed cerebrovascular and cardiovascular events and reduced carotid intima-media thickness in patients with coronary heart disease in a clinical trial [14]. The polyphenol contents of mulberry are very similar to those of mulberry leaf, thereby suggesting that mulberry polyphenols (MPE) may also play a role in anti-atherosclerosis treatment [15].…”