Mulberry leaf (Morus alba L.): A review of its potential influences in mechanisms of action on metabolic diseases

Zhang, Ruiyuan; Qian, Zhang; Zhu, Shun; Liu, Biyang; Liu, Fang; Xu, Yao‐Chang

doi:10.1016/j.phrs.2021.106029

Cited by 71 publications

(48 citation statements)

References 104 publications

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“…Mori folium, commonly known as mulberry leaf, is the dried leaf of Morus alba L. of Moraceae [31,32]. Given its rich bioactive components and nutritional value, mulberry leaf has been widely used in functional foods such as herbal teas, beverages, and noodles in China, Japan, and Korea [115]. Mulberry leaf possesses biological activities of hypolipidemia, hypoglycemia, antibacterial, anti-atherosclerosis, anti-inflammatory and antioxidation [116,117].…”

Section: Mori Folium (Sangye)mentioning

confidence: 99%

Medicinal and edible plants in the treatment of dyslipidemia: advances and prospects

Chen

et al. 2022

Chin Med

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Dyslipidemia is an independent risk factor of cardiovascular diseases (CVDs), which lead to the high mortality, disability, and medical expenses in the worldwide. Based on the previous researches, the improvement of dyslipidemia could efficiently prevent the occurrence and progress of cardiovascular diseases. Medicinal and edible plants (MEPs) are the characteristics of Chinese medicine, and could be employed for the disease treatment and health care mostly due to their homology of medicine and food. Compared to the lipid-lowering drugs with many adverse effects, such as rhabdomyolysis and impaired liver function, MEPs exhibit the great potential in the treatment of dyslipidemia with high efficiency, good tolerance and commercial value. In this review, we would like to introduce 20 kinds of MEPs with lipid-lowering effect in the following aspects, including the source, function, active component, target and underlying mechanism, which may provide inspiration for the development of new prescription, functional food and complementary therapy for dyslipidemia.

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Section: Mori Folium (Sangye)mentioning

confidence: 99%

Medicinal and edible plants in the treatment of dyslipidemia: advances and prospects

Chen

et al. 2022

Chin Med

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“…The HPLC chromatogram of TFM at 254 nm and the MS/MS data are shown in Supplementary S2.1. The 1 H and 13 C NMR data of the purified components are summarized in Supplementary S2.2.…”

Section: ■ Resultsmentioning

confidence: 99%

“…nigra L. are rich in alkaloids, polysaccharides, and flavonoids and exhibit multiple biological activities, including antioxidation, anticancer, and anti-inflammation, , resulting in the high value of M. nigra L. in nutrients and nutraceuticals. − Flavonoids are the main active ingredients in the twigs of M. nigra L., which involve Diels–Alder adducts, isopentenyl flavonoids, prenylated flavonoids, and flavanols.…”

Section: Introductionmentioning

confidence: 99%

“…1 H and13 C NMR data of purified components; dose determination of TFM in vivo; level of GPT and GOT in plasma; intestinal microbiota sequencing; SCFA levels in feces; heatmap of transcription; GO analysis; dose determination of TFM in vitro; and heatmap cluster analysis of indicators (PDF) ; GPT, glutamic pyruvic transaminase; GOT, glutamic oxaloacetic transaminase; LDL-C, low-density lipoprotein; HDL-C, high-density lipoprotein; TC, total cholesterol; TG, triglyceride; AKT, protein kinase B; GSK3β, glycogen synthase kinase 3β; ZO-1, zona occludens-1; IRβ, insulin receptor; OGTT, oral glucose tolerance test; PBG, postprandial blood glucose; HOMA-IR, insulin resistance index; ITT, insulin tolerance test; NGS, next-generation sequencing; TLR4, toll-like receptor 4…”

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confidence: 99%

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Ameliorating Effect of the Total Flavonoids of Morus nigra L. on Prediabetic Mice Based on Regulation of Inflammation and Insulin Sensitization

Ren

Sun

Guo

et al. 2022

J. Agric. Food Chem.

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Prediabetes is a critical stage characterized by insulin resistance. Morus nigra L., an edible plant, is widely used in food and nutritive supplements and exhibits various pharmacological activities; however, its therapeutic effects and mechanisms on prediabetes have rarely been reported. In this research, the major components of total flavonoids of M. nigra L. (TFM) were identified, and TFM treatment was found to reduce prediabetes progressing to type 2 diabetes mellitus (T2DM) from 93.75 to 18.75%. The microbiota and next-generation sequencing combined with western blotting in vivo and in vitro demonstrated that TFM and its components ameliorated insulin resistance mediated by the suppressor of cytokine signaling and protein tyrosine phosphatase 1B, which benefited by maintaining intestinal homeostasis and restraining plasma levels of inflammatory factors. This study confirmed the T2DM prevention effect of TFM and revealed the underlying mechanism, setting the stage for the design of functional foods for diabetes prevention.

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“…Mulberry leaves contain numerous bioactive compounds, such as flavonoids and phenolic acids, which are responsible for their antioxidant activity. A study reported that high-dose 1-deoxynojirimycin (1-DNJ), which is found to be distributed among the mulberry species, reduces aspartate transferase (AST) and alanine transferase (ALT) levels, and increases sensitivity to fat in high-fat mice [ 12 , 13 ]. The 1-DNJ significantly reduces intestinal glucose absorption [ 14 ], improves the serum lipid profile in coronary heart disease [ 15 ], inhibits metastasis of melanoma cells [ 16 ], and improves insulin sensitivity [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Mulberry Leaf Supplements Effecting Anti-Inflammatory Genes and Improving Obesity in Elderly Overweight Dogs

Park

Jaiswal²,

Kim³

et al. 2022

IJMS

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Overweight and obesity, associated with various health complications, refer to abnormal or excessive fat accumulation conditions that harm health. Like humans, obesity is a growing problem in dogs, which may increase the risk of serious diseases such as diabetes and cancer. Mulberry leaf has shown potential anti-obesity and anti-diabetes effects in several studies. Our research studied the impact of mulberry leaf supplements in healthy old overweight dogs for 12 weeks. Blood and fecal samples were collected from the dogs before and after treatment for different analyses, including whole transcriptome and gut microbiome analysis. The Body Condition Score (BCS) and blood glucose levels were significantly decreased in all mulberry treatment groups, which justifies the anti-obesity effect of mulberry leaf in dogs. Throughout the whole transcriptome study, the downregulation of PTX3 and upregulation of PDCD-1, TNFRSF1B, RUNX3, and TICAM1 genes in the high mulberry group were found, which have been associated with anti-inflammatory effects in the literature. It may be an essential gene expression mechanism responsible for the anti-inflammatory and, subsequently, anti-obesity effects associated with mulberry leaf treatment, as confirmed by real-time polymerase chain reaction analysis. In microbiome analysis, Papillibacter cinnamivorans, related to the Mediterranean diet, which may cause anti-inflammatory effects, were abundant in the same treatment group. Further studies may be required to establish the gene expression mechanism and role of abundant bacteria in the anti-obesity effect of mulberry supplements in dogs. Overall, we propose mulberry leaves as a portion of food supplements for improving blood glucose levels and the anti-inflammation of blood in companion dogs.

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Mulberry leaf (Morus alba L.): A review of its potential influences in mechanisms of action on metabolic diseases

Cited by 71 publications

References 104 publications

Medicinal and edible plants in the treatment of dyslipidemia: advances and prospects

Medicinal and edible plants in the treatment of dyslipidemia: advances and prospects

Ameliorating Effect of the Total Flavonoids of Morus nigra L. on Prediabetic Mice Based on Regulation of Inflammation and Insulin Sensitization

Mulberry Leaf Supplements Effecting Anti-Inflammatory Genes and Improving Obesity in Elderly Overweight Dogs

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