Multi-centre, randomized clinical trial on the efficacy and safety of recombinant human platelet-derived growth factor with β-tricalcium phosphate in human intra-osseous periodontal defects

Jayakumar, Avula; Palaparthi, Rajababu; Rohini, S; Kalakonda, Butchibabu; Naveen, Anumala; Reddy, Pathakota Krishnajaneya; Vidyasagar, Sisinty; Satyanarayana, D.; Kumar, Sayini Pavan

doi:10.1111/j.1600-051x.2010.01639.x

Cited by 103 publications

(136 citation statements)

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“…The radiographic defect angle of each defect was measured between the CEJ-BD line of the involved tooth and the bone defect surface [24,25]. Linear defect fill (LDF) was calculated by subtracting CEJ-BD distance at the end of 12 months from CEJ-BD at baseline, while percentage defect fill (%DF) by dividing LDF by DD at baseline [26].…”

Section: Radiographic Assessmentsmentioning

confidence: 99%

Treatment of intrabony defects with modified perforated membranes in aggressive periodontitis: a 12-month randomized controlled trial

et al. 2018

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Objective The aim of this study was to compare the clinical and radiographic efficacy of guided tissue regeneration with a modified perforated collagen membrane (MPM) or standard collagen membrane (CM) in the treatment of intrabony defects in patients with aggressive periodontitis (AgP). Materials and methods Fifteen AgP patients were included in the study. Two single intrabony defects of at least 3 mm depth with ≥ 6 mm probing pocket depth (PPD) from each patient were randomly assigned to either xenogenic graft plus MPM (test group) or xenogenic graft plus CM (control group). PPD, clinical attachment level (CAL), and gingival recession (GR) were recorded at baseline and at 12 months. The radiographic assessments included the measurements of defect depth (DD), change in alveolar crest position (ACP), linear defect fill (LDF), and percentage defect fill (%DF). Results After treatment, PPD, CAL, DD, and ACP values improved significantly in both groups, without statistical differences between them. However, with respect to LDF and %DF, the 12-month radiographic analysis at MPM-treated sites showed a significant improvement compared to the 6-month outcomes, that was not observed at control sites (additional LDF of 0.4 ± 0.5 mm, p = 0.010 and %DF of 6.4 ± 7.6%, p = 0.025). Conclusions Both strategies proved effective in the treatment of intrabony defects in patients with AgP. Nonetheless, enhanced LDF and %DF 12 months postoperatively at MPM-treated sites may stem from cellular and molecular migration from the periosteum and overlying gingival connective tissue through barrier's pores. Clinical relevance Modification of CM may have positive ramifications on periodontal regeneration.

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Section: Radiographic Assessmentsmentioning

confidence: 99%

Treatment of intrabony defects with modified perforated membranes in aggressive periodontitis: a 12-month randomized controlled trial

et al. 2018

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“…For example, an application of recombinant human growth and differentiation factor-5 (rhGDF-5) lyophilized onto β-TCP granules demonstrated an effective regeneration of the artificially created periodontal defects [549,550]. Positive results were also obtained for a combination of a recombinant human platelet-derived growth factor BB (rhPDGF-BB) with β-TCP for the treatment of human intra-osseous periodontal defects [551,552]. However, a combination of an enamel matrix derivative with BCP (HA + β-TCP) resulted in no to minimal new bone formation [491].…”

Section: Periodontics (Periodontology)mentioning

confidence: 84%

“…[491,[549][550][551][552][553][554][555]. For example, an application of recombinant human growth and differentiation factor-5 (rhGDF-5) lyophilized onto β-TCP granules demonstrated an effective regeneration of the artificially created periodontal defects [549,550].…”

Section: Periodontics (Periodontology)mentioning

confidence: 99%

Calcium Orthophosphates (CaPo ) and Dentistry

Dorozhkin¹

2016

Bioceram Dev Appl

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“…The majority of the studies indicate no added benefits either in clinical and radiographic gains when EMD is used with the addition of graft materials.4) rhPDGF-BB. rhPDGF-BB can be safely used with therapeutic results comparable to those of other regenerative approaches [24][25]. …”

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confidence: 95%

Regenerative Therapies in the Treatment of Intrabony Defects Show High Clinical Efficacy

Cairo

Pagliaro²

2015

Journal of Evidence Based Dental Practice

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Multi-centre, randomized clinical trial on the efficacy and safety of recombinant human platelet-derived growth factor with β-tricalcium phosphate in human intra-osseous periodontal defects

Abstract: rhPDGF-BB+β-TCP is safe and effective in the treatment of periodontal defects. It increases bone formation and soft tissue healing (clinicaltrials.gov, number NCT00496847; CTRI No.: CTRI/2008/091/000152).

Cited by 103 publications

References 29 publications

Treatment of intrabony defects with modified perforated membranes in aggressive periodontitis: a 12-month randomized controlled trial

Treatment of intrabony defects with modified perforated membranes in aggressive periodontitis: a 12-month randomized controlled trial

Calcium Orthophosphates (CaPo ) and Dentistry

Regenerative Therapies in the Treatment of Intrabony Defects Show High Clinical Efficacy

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