Multi-Component One-Pot Assisted Synthesis, Anti-bacterial Capabilities, and Scanning Electron Microscopy of Novel Corticosteroid Thiopyran

Abstract

Background: Corticosteroids are important group of polycyclic compounds having a wide range of pharmacological and physiological properties. Thiopyran derivatives are important building blocks of many biologically active compounds. Objective: Keeping in mind the wide range of application of corticosteroid and thiopyran, herein we intend to develop a simple and efficient strategy to synthesize steroidal thiopyran derivatives starting with different commercially available corticosteroid and study their biological property. Materials and Methods: To achieve our aim, we employed a one-pot multicomponent synthesis of steroidal thiopyran derivatives by the reaction of corticosteriods, malononitrile and carbon disulphide in presence of triethyl amine as a catalyst. Results and Discussion : An array of novel thiopyran compounds were obtained with the highest product yield using Et3N. Scanning electron microscopy analysis manifested agglomeration pertaining to brick - shaped crystals of corticosteroid thiopyran. Synthesized compound were also found to be active as antibacterial agents. Conclusion: We describe a facile one-pot multicomponent synthesis of corticosteroid thiopyran derivatives which are found to possess antibacterial activity. Excellent yields of the products, simple work-up, easily available starting materials and non-chromatographic purification are some main advantages of this protocol.