Multi‐Component Reaction via gem ‐Difunctionalization of Metal Carbene

Construction of 4-hydroxycoumarin derivatives with adjacent quaternary and tertiary stereocenters via ternary catalysis

“…Multicomponent reactions have emerged as a powerful strategy for efficient synthesis of complex heterocycles. [23][24][25][26][27][28][29][30] In past decades, an astounding number of binary-catalytic multicomponent reactions via interception of active ylide intermediates or zwitterionic intermediates derived from different carbene precursors have been developed by Gong, 31,32 Schneider, 33 Wang, 34 us [35][36][37][38][39][40][41][42] and others, 43,44 providing an efficient access to structurally diverse and functionalized heterocyclic scaffolds with one-pot operation under mild conditions (Scheme 1c). However, the development of ternary catalysis systems among higher-order multicomponent reactions is sluggish.…”