Multi-effective components and their target mechanism of Ziziphi Spinosae Semen in the treatment of insomnia

Zhao, Xinwei; Hou, Tao; Zhou, Han; Liu, Ziling; Liu, Yanfang; Wang, Chaoran; Guo, Zhimou; Yu, Dongping; Xu, Qing; Wang, Jixia; Liang, Xinmiao

doi:10.1016/j.fitote.2023.105712

Fitoterapia

2023

DOI: 10.1016/j.fitote.2023.105712

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Multi-effective components and their target mechanism of Ziziphi Spinosae Semen in the treatment of insomnia

Xinwei Zhao,

Tao Hou,

Han Zhou

et al.

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2024

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Cited by 4 publications

References 49 publications

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Research progress on the effect of medicine and food homology resources for sleep improvement

Ma,

Huang,

Shi

et al. 2024

Heliyon

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Research progress on the effect of medicine and food homology resources for sleep improvement

Ma,

Huang,

Shi

et al. 2024

Heliyon

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The therapeutic potential of Ziziphi Spinosae Semen and Polygalae Radix in insomnia management: Insights from gut microbiota and serum metabolomics techniques

Ren,

Kong,

Zhang

et al. 2024

Journal of Ethnopharmacology

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Characterization and Improvement of Sleep Activity of Ziziphi Spinosae Semen Oil Microcapsules Prepared by Complex Coacervation

Chen,

Shi*,

Tang**

et al. 2024

Natural Product Communications

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Objective: Ziziphi Spinosae Semen oil (ZSSO) is a fatty oil extracted from Ziziphi Spinosae Semen, and its main component is unsaturated fatty acid. It is susceptible to oxidation and deterioration. The aim of this study was to improve the stability of ZSSO and protect its quality. Methods: gelatin-sodium alginate was used as the wall material for the preparation of ZSSO microcapsules by the complex coacervation. The particle size and zeta potential of the microcapsules were determined using a Malvern particle size meter. The microstructure and stability of the microcapsules were determined by SEM, FTIR, TGA and PV. The sleep-improving activity of the microcapsules was also determined by sleep induction assay, Elisa and HE staining. Results: The encapsulation efficiency of microcapsules was 56.08% ± 0.19%, average particle size was 166.17 nm, and zeta potential was 38.2. Morphology of microcapsules was observed by SEM. The FTIR results showed that the fatty oil was successfully embedded, and PV indicated that microcapsules had a slow oxidation rate. A preliminary study on the sleep-improving activity of ZSSO and microcapsules demonstrated that it could shorten sleep latency and prolong sleep time of insomniac mice, and increase the levels of 5-HT and GABA and decrease the level of Glu in the brain of mice. In addition, ZSSO and microcapsules can repair damaged neuronal cells in the hypothalamus of insomniac mice to improve sleep. Conclusion: The quality evaluation of the microcapsules indicates that the prepared ZSSO-MPs have a small particle size and good stability. Moreover, ZSSO and microcapsules can effectively improve the sleep status of insomnia mice.

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Multi-effective components and their target mechanism of Ziziphi Spinosae Semen in the treatment of insomnia

Cited by 4 publications

References 49 publications

Research progress on the effect of medicine and food homology resources for sleep improvement

Research progress on the effect of medicine and food homology resources for sleep improvement

The therapeutic potential of Ziziphi Spinosae Semen and Polygalae Radix in insomnia management: Insights from gut microbiota and serum metabolomics techniques

Characterization and Improvement of Sleep Activity of Ziziphi Spinosae Semen Oil Microcapsules Prepared by Complex Coacervation

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