Multi-elemental trace analysis of human serum by double-focusing ICP-MS

Muñiz, Cristina Sariego; Marchante-Gayón, Juan Manuel; Alonso, J. Ignacio García; Sanz‐Medel, Alfredo

doi:10.1039/a807360k

Cited by 62 publications

(21 citation statements)

References 25 publications

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“…A statistically significantly increased concentration of Fe and a dramatically increased concentration of Mn were found in the IHD case group compared with the control group (p < 0.05). This procedure was performed following the postulates of Muniz et al [ 28 ]. Further, the same parameters of the IHD patient and healthy control groups were used to perform the congruous analysis.…”

Section: Resultsmentioning

confidence: 99%

“…It is apparently hypothesized that metabolic imbalances regarding zinc and copper are a major factor in the etiology of ischemic heart disease based on consistent epidemiologic and metabolic data. Metabolic imbalances are either relative or absolute deficiencies of Cu or Zn that can be characterized by the ratio of Zn to Cu [ 28 , 29 , 30 ]. Zn as a vital trace element that functions such as a co-factor in several synthetic enzymes and is also required for the proper antioxidant functioning to protect against free radical injury [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

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A clinical evaluation of the alterations in the level of serum zinc, copper, iron, and manganese in the ischemic heart disease patients of Bangladesh - A case-control study

Anonna

Ahamed

Uddin

et al. 2020

Heliyon

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Background Ischemic heart disease (IHD) is a major cause of death globally. Countries vary in their rates, and changes have occurred over time. Nowadays, developing countries pose new public health challenges. Objectives The objective of the present study was to appraise the alterations in the levels of serum Zn, Cu, Fe, and Mn that occur in patients with ischemic heart disease and to depict the correlations of the effects of these changes that lead to the pathogenesis of IHD. Methods Zn, Cu, Fe, and Mn in the IHD patients were determined by Atomic Absorption Spectroscopy (AAS). Results This study evaluated 52 patients with IHD, and 61 healthy volunteers served as controls. The primary outcomes of interest were explored regarding the correlations of the serum levels of these trace elements in patients with IHD. The secondary outcomes were explored in terms of inter-element relations to connect them with the pathogenesis of IHD. Our study found significantly reduced levels of Zn and Cu (2.50 ± 0.19 mg/L and 2.52 ± 0.17 mg/L, respectively) and an elevated level of Fe (148.97 ± 17.25 mg/L) in the patient group with IHD. The level of Mn (7.32 ± 1.23 mg/L) was elevated in the sera of the patients with ischemic heart disease (IHD) compared to healthy control subjects. Conclusion Our results indicate strong associations of the pathogenesis of IHD with depleted serum levels of Zn and Cu and elevated Fe and Mn levels, which may provide a prognostic tool for the treatment of this concerning the disease.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A clinical evaluation of the alterations in the level of serum zinc, copper, iron, and manganese in the ischemic heart disease patients of Bangladesh - A case-control study

Anonna

Ahamed

Uddin

et al. 2020

Heliyon

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“…225,257 Applications in Biology, Biochemistry and Medicine Analysis of complex biological matrices, most often rich in carbon and salts, requires analytical instrumentation capable of coping with spectral interferences for determination of target elements at steadily decreasing concentration levels. 210,[258][259][260] High mass resolution has become the method of choice when facing low-level multielement analysis in biological and clinical samples. 173 The capability of high mass resolution devices for the speciation of biomolecules was soon recognised in the scientific community as well and the combination of molecular and elemental mass spectrometry represents a powerful synergy in modern life-science applications.…”

Section: Applications In Life-science Researchmentioning

confidence: 99%

Inductively Coupled Plasma Mass Spectrometry

Jakubowski

Horsky

Roos

et al. 2014

Sector Field Mass Spectrometry for Elemental and Isotopic Analysis

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ICP-MS is based on the formation of (preferentially monovalent positively) charged atomic ions in an inductively coupled Ar plasma at almost 10 000 K. The ions formed are transferred from the plasma source at ambient pressure into a mass separator operated at high vacuum via a set of cones. The ions are separated according to their mass/charge ratio in the mass separator (quadrupole, magnetic sector field or time-of-flight mass separator). In most cases, the ions are detected using a secondary electron multiplier; in some set-ups (also) a Faraday cup can be used. Single-collector (scanning mass spectrometer usually used for quantitative elemental analysis) or multicollector (static operation of mass spectrometer for precise isotope ratio analysis) configurations can be found (Figures 12.1 and 12.2).

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“…Many techniques have been reported to control and suppress the spectral interferences such as the correction equation, the removal of interfering elements and/or compounds, low temperature plasma, and high resolution mass spectrometry. [11][12][13][14][15][16] Recently, the collision/reaction gas cell methods have been applied to ICP-MS to remove the interferences of coexisting ions. [17][18][19][20][21] Helium (He), H2, NH3, CH4, and O2 are usually used as collision/reaction gases in this technique and some interference are reduced based on the following physical/chemical phenomena such as the kinetic energy discrimination (KED), collision induced dissociation (CID), oxidization, etc.…”

Section: Introductionmentioning

confidence: 99%