Multi-functional bioactive secondary metabolites derived from endophytic fungi of marine algal origin

Harikrishnan, M.; P, Saipriya P.; Prakash, Prabha; Jayabaskaran, Chelliah; Bhat, Sarita G.

doi:10.1016/j.crmicr.2021.100037

Cited by 6 publications

(5 citation statements)

References 31 publications

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“…Phenol, 2,4-bis(1,1-dimethylethyl) was found in fermented seaweeds and Kappaphycus spp. red algae enhanced with endophytic mushroom fermentation [48,49]. In this study, phenol, 2,4-bis(1,1-dimethylethyl) substance in J. rubens EE (25.64%) could limit the antimicrobial activity of microorganisms other than C. tropicalis.…”

Section: Gc-ms Analysis Of J Rubens Extractsmentioning

confidence: 73%

The Anti-candidal and Absorbtion Performance of PVA/PVP-Based Jania rubens Hydrogel on Candida tropicalis and Some Physicochemical Properties of the Hydrogel

Boran,

Eliuz,

Ayas

2024

Appl Biochem Biotechnol

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This study was aimed to create a bioactive hydrogel form with PVA/PVP (polyvinyl alcohol/poly(N-vinylpyrrolidone) polymer using acetone and ethanol extractions of Janiarubens red algae and investigate some pharmaceutical properties. The anti-candidal activity and some inhibition performance of J. rubens/PVA/PVP hydrogel were investigated on Candida tropicalis which is one of the important causes of bloodstream infections. The physicochemical properties of J. rubens/PVA/PVP hydrogel were revealed using FTIR and swelling-absorption tests. The volatile compounds of J. rubens extracts were examined by GCMS. By mixing the extracts in equal proportions, PVA/PVP-based hydrogel was prepared. According to the results, Cumulative Drug Release was stable at 25 °C for the first 5 h. The IZ (inhibition zone) and MIC (minimum inhibitory concentration) of J. rubens/PVA/PVP hydrogel were 9.01 mm and 80.20 mg/mL, respectively. It was found that logarithmic reduction and percent reduction were seen as 1.5 CFU/mL and 97.5%, respectively, on C. tropicalis exposed to J. rubens/PVA/PVP hydrogel in the first 5 min of the incubation. After exposure of C. tropicalis to J. rubens/PVA/PVP, the number of viable cells transferred from the gel to water was between 76.1 and 73.1% in high glucose medium, while it was between 92.2 and 80.8% for the PVA/PVP hydrogel under the same conditions. As a result, PVA/PVP hydrogel was made bioactive with J. rubens extracts for the first time in this study, and its potential for use as a functional anticandidal hydrogel on C.tropicalis has been demonstrated.

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Section: Gc-ms Analysis Of J Rubens Extractsmentioning

confidence: 73%

The Anti-candidal and Absorbtion Performance of PVA/PVP-Based Jania rubens Hydrogel on Candida tropicalis and Some Physicochemical Properties of the Hydrogel

Boran,

Eliuz,

Ayas

2024

Appl Biochem Biotechnol

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“…is study found 45 strains of endophytic fungi and 10 selected strains were tested for cytotoxicity as well as antifungal and antibacterial activity (de Felício et al, 2015). A smaller number of endophytic fungi isolates were found in the research of Harikrishnan et al, (2021), who isolated endophytic fungi from macroalgae on the west coast of South India.…”

Section: Discussionmentioning

confidence: 99%

Isolation and Molecular Identification of Endophytic Fungi Associated with Brown Algae for Inhibiting Escherichia coli ESBL

Wiradana,

Permatasari,

Sari

et al. 2024

J. Appl. Vet. Sci. Technol

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Background: The marine environment is the main source of research on natural products in the future. In addition, marine microorganisms have been identified as a natural source capable of developing new antibiotic compounds, including controlling urinary tract infections caused by Escherichia coli ESBL. Purpose: This study aims to isolate, select, and test the potential of brown macroalgae endophytic fungi (Phaeophyceae) collected from the coastal waters of Sanur, Bali Province. Methods: Three types of brown algae were collected from Sanur Beach and their endophytic fungi were isolated using PDA media. Antibacterial activity was determined by measuring the inhibition zone and determining the inhibition category. The selected isolates were cultured and the phytochemical profile was determined qualitatively. In addition, molecular identification using the Internal Transcribed Spacer (ITS) primer set and comparison with the GenBank (NCBI) database were carried out in this study. Results: The results showed that 10 isolates were successfully isolated from three types of brown macroalgae. It was found that isolates T1, S1, and P3 had the highest inhibition in the very strong category. There were variations in mycelial weight, pH value, and inhibition shown by the culture filtrate of the three endophytic fungal isolates against Escherichia coli ESBL. Isolate S1 had the highest phytochemical profile, namely alkaloids, triterpenoids, saponins, and phenolics. The three endophytic fungal isolates showed isolate T1 (Phlebiopsis magnicystidiata) (MT5617191), isolate P3 (Neurospora crassa strain RT3M) (MT1028551), and isolate S1 (Peniophora sp.) (MH2680421). Conclusion: The results of this study provide initial information regarding the potential of bioprospecting brown macroalgal endophytic fungi as a source of new antibiotics against Escherichia coli ESBL.

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“…Hasil ini menunjukkan bahwa senyawa bioaktif yang diisolasi dari jamur endofit menghasilkan aktivitas antibakteri yang lebih baik terhadap S.aureus daripada ekstrak kasar jamur endofit [29]. Ekstrak etil asetat Penicillium dalae juga memiliki aktivitas antibakteri yang paling besar terhadap Pseudomanas aeruginosa pada konsentrasi 350 ppm dibandingkan dengan ekstrak jamur endofit Rigidoporus vinctus, Cystobasidium minutum dan Candida railenensis [25].…”

Section: Hasil Dan Pembahasanunclassified

“…Selain dengan metode mikrodilusi dan difusi agar, uji antibakteri juga dapat dilakukan dengan metode dilusi, seperti yang dilakukan oleh Habbu et [25]. Dimana senyawa ini bertanggungjawab terhadap aktivitas antibakteri dan antioksidan pada jamur endofit Cystobasidium minutum yang diisolasi dari alga Rhizoclonium.…”

Section: Hasil Dan Pembahasanunclassified

“…Dimana senyawa ini bertanggungjawab terhadap aktivitas antibakteri dan antioksidan pada jamur endofit Cystobasidium minutum yang diisolasi dari alga Rhizoclonium. Kehadiran senyawa antimikroba, 2-Ethylacridine, Asam silikat, dan dietil bis(trimetilsilil) masing-masing pada jamur endofit Rigidoporus vinctus dan Candida railenensis [25]. Senyawa ergosteroid baru yaitu isosiathisterol (29) yang diisolasi dari jamur endofit Aspergillus ustus memiliki aktivitas sedang pada bakteri E.coli dan S.aureus dengan zona hambat 6,7 mm dan 5,7 mm [23].…”

Section: Hasil Dan Pembahasanunclassified

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Review: Potensi Jamur Endofit dari Divisi Alga Hijau (Chlorophyta) sebagai Antibakteri beserta Kandungan Senyawa Bioaktifnya

I Gusti Agung Istri Agung Pramiari,

Ni Putu Ariantari

2023

WSNF

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Peningkatan risiko dalam berkembangnya beberapa agen infeksius seperti bakteri menyebabkan adanya kebutuhan agen senyawa obat baru yang konstruktif. Saat ini, jamur endofit dianggap sebagai sumber produk alami baru yang efektif untuk keperluan medis. Jamur endofit laut telah ditemukan pada setiap tumbuhan laut, salah satunya adalah divisi alga hijau (Chlorophyta). Setiap jamur endofit menghasilkan metabolit sekunder dan senyawa bioaktif, sehingga berpotensi sebagai agen antimikroba. Kajian ini disusun berdasarkan studi literatur jurnal nasional dan internasional menggunakan basis data Google Scholar, Science Direct, dan PubMed yang kemudian dipilih sesuai kriteria inklusi dan eksklusi. Dari hasil penelitian yang telah dikumpulkan (2010-2023) terdapat 20 spesies jamur endofit yang berhasil diisolasi dari alga hijau. Spesies dari genus Penicillium (20%) mayoritas ditemukan sebagai jamur endofit dari alga hijau. Berbagai hasil studi, menunjukkan ekstrak kasar dan senyawa bioaktif jamur endofit yang diisolasi dari alga hijau memiliki aktivitas antibakteri yang bervariasi, mulai dari sedang hingga sangat kuat sehingga berpeluang dikembangkan lebih lanjut sebagai sumber agen antibakteri baru.

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Multi-functional bioactive secondary metabolites derived from endophytic fungi of marine algal origin

Cited by 6 publications

References 31 publications

The Anti-candidal and Absorbtion Performance of PVA/PVP-Based Jania rubens Hydrogel on Candida tropicalis and Some Physicochemical Properties of the Hydrogel

The Anti-candidal and Absorbtion Performance of PVA/PVP-Based Jania rubens Hydrogel on Candida tropicalis and Some Physicochemical Properties of the Hydrogel

Isolation and Molecular Identification of Endophytic Fungi Associated with Brown Algae for Inhibiting Escherichia coli ESBL

Review: Potensi Jamur Endofit dari Divisi Alga Hijau (Chlorophyta) sebagai Antibakteri beserta Kandungan Senyawa Bioaktifnya

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