Multi‐Functional Liposome: A Powerful Theranostic Nano‐Platform Enhancing Photodynamic Therapy

Cheng, Xiamin; Gao, Jing; Ding, Yang; Lu, Yao; Wei, Qiancheng; Cui, Dezhi; Fan, Jiali; Li, Xiaoman; Zhu, Ershu; Lu, Yongna; Wu, Qiong; Li, Lin; Huang, Wei

doi:10.1002/advs.202100876

Cited by 126 publications

(81 citation statements)

References 245 publications

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“…Improved PS absorption and PDT antitumour effects were observed in the HT-29 human colorectal adenocarcinoma cell line [75]. The liposomal formulation most likely improved the delivery of the PS [73,76].…”

Section: Nps-mediated Ps Delivery In Crc Pdtmentioning

confidence: 97%

Nanoparticle-Mediated Delivery Systems in Photodynamic Therapy of Colorectal Cancer

Simelane

Abrahamse

2021

IJMS

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Colorectal cancer (CRC) involving a malignant tumour remains one of the greatest contributing causes of fatal mortality and has become the third globally ranked malignancy in terms of cancer-associated deaths. Conventional CRC treatment approaches such as surgery, radiation, and chemotherapy are the most utilized approaches to treat this disease. However, they are limited by low selectivity and systemic toxicity, so they cannot completely eradicate this disease. Photodynamic therapy (PDT) is an emerging therapeutic modality that exerts selective cytotoxicity to cancerous cells through the activation of photosensitizers (PSs) under light irradiation to produce cytotoxic reactive oxygen species (ROS), which then cause cancer cell death. Cumulative research findings have highlighted the significant role of traditional PDT in CRC treatment; however, the therapeutic efficacy of the classical PDT strategy is restricted due to skin photosensitivity, poor cancerous tissue specificity, and limited penetration of light. The application of nanoparticles in PDT can mitigate some of these shortcomings and enhance the targeting ability of PS in order to effectively use PDT against CRC as well as to reduce systemic side effects. Although 2D culture models are widely used in cancer research, they have some limitations. Therefore, 3D models in CRC PDT, particularly multicellular tumour spheroids (MCTS), have attracted researchers. This review summarizes several photosensitizers that are currently used in CRC PDT and gives an overview of recent advances in nanoparticle application for enhanced CRC PDT. In addition, the progress of 3D-model applications in CRC PDT is discussed.

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Section: Nps-mediated Ps Delivery In Crc Pdtmentioning

confidence: 97%

Nanoparticle-Mediated Delivery Systems in Photodynamic Therapy of Colorectal Cancer

Simelane

Abrahamse

2021

IJMS

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“…Hypoxia, including PDT‐induced hypoxia or hypoxic tumor microenvironment, will largely compromise the therapeutic effect of PDT, which mainly relies on oxygen consumption type II mechanism. [ 110 ] Notably, elevating oxygen supply allows to alleviate tumor hypoxia and ameliorate hypoxia‐induced the adverse impact of PDT treatment. [ 111 ] There are several strategies to replenish oxygen content.…”

Section: Biomedical Applications Of Ucnp‐mof Heterostructuresmentioning

confidence: 99%

Heterostructures Made of Upconversion Nanoparticles and Metal–Organic Frameworks for Biomedical Applications

Liu

et al. 2021

Advanced Science

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Heterostructure nanoparticles (NPs), constructed by two single‐component NPs with distinct nature and multifunctional properties, have attracted intensive interest in the past few years. Among them, heterostructures made of upconversion NPs (UCNPs) and metal–organic frameworks (MOFs) can not only integrate the advantageous characteristics (e.g., porosity, structural regularity) of MOFs with unique upconverted optical features of UCNPs, but also induce cooperative properties not observed either for single component due to their special optical or electronic communications. Recently, diverse UCNP‐MOF heterostructures are designed and synthesized via different strategies and have demonstrated appealing potential for applications in biosensing and imaging, drug delivery, and photodynamic therapy (PDT). In this review, the synthesis strategies of UCNP‐MOF heterostructures are first summarized, then the authors focus mainly on discussion of their biomedical applications, particularly as PDT agents for cancer treatment. Finally, the authors briefly outlook the current challenges and future perspectives of UCNP‐MOF hybrid nanocomposites. The authors believe that this review will provide comprehensive understanding and inspirations toward recent advances of UCNP‐MOF heterostructures.

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“…The modern generation of liposomes includes lipid-based targeted and theranostic nanoplatforms, obtained by the engineering of the phospholipid nanostructures [ 22 , 23 , 24 , 25 , 26 ]. All those varieties of liposome nanoplatforms stimulated a great effort for the scale-up of the fabrication methods in view of industrial developments.…”

Section: Introductionmentioning

confidence: 99%

Methods of Liposomes Preparation: Formation and Control Factors of Versatile Nanocarriers for Biomedical and Nanomedicine Application

2022

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Liposomes are nano-sized spherical vesicles composed of an aqueous core surrounded by one (or more) phospholipid bilayer shells. Owing to their high biocompatibility, chemical composition variability, and ease of preparation, as well as their large variety of structural properties, liposomes have been employed in a large variety of nanomedicine and biomedical applications, including nanocarriers for drug delivery, in nutraceutical fields, for immunoassays, clinical diagnostics, tissue engineering, and theranostics formulations. Particularly important is the role of liposomes in drug-delivery applications, as they improve the performance of the encapsulated drugs, reducing side effects and toxicity by enhancing its in vitro- and in vivo-controlled delivery and activity. These applications stimulated a great effort for the scale-up of the formation processes in view of suitable industrial development. Despite the improvements of conventional approaches and the development of novel routes of liposome preparation, their intrinsic sensitivity to mechanical and chemical actions is responsible for some critical issues connected with a limited colloidal stability and reduced entrapment efficiency of cargo molecules. This article analyzes the main features of the formation and fabrication techniques of liposome nanocarriers, with a special focus on the structure, parameters, and the critical factors that influence the development of a suitable and stable formulation. Recent developments and new methods for liposome preparation are also discussed, with the objective of updating the reader and providing future directions for research and development.

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Multi‐Functional Liposome: A Powerful Theranostic Nano‐Platform Enhancing Photodynamic Therapy

Cited by 126 publications

References 245 publications

Nanoparticle-Mediated Delivery Systems in Photodynamic Therapy of Colorectal Cancer

Nanoparticle-Mediated Delivery Systems in Photodynamic Therapy of Colorectal Cancer

Heterostructures Made of Upconversion Nanoparticles and Metal–Organic Frameworks for Biomedical Applications

Methods of Liposomes Preparation: Formation and Control Factors of Versatile Nanocarriers for Biomedical and Nanomedicine Application

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