Multi-functional nanocellulose-chitosan dressing loaded with antibacterial lawsone for rapid hemostasis and cutaneous wound healing

Sultana, Tamanna; Hossain, Monir; Rahaman, Sohanur; Kim, Yong Sik; Gwon, Jaegyoung; Lee, Byong‐Taek

doi:10.1016/j.carbpol.2021.118482

Cited by 76 publications

(30 citation statements)

References 53 publications

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“…Furthermore, previous reports showed that the wound dressings with pore sizes ranging from 20 to 125 μm had a decisive function in furnishing the dermal cells with oxygen and necessary nourishments, thereby ameliorating the regeneration of skin tissues [ 32 ]. Moreover, it has been reported that the measurements of significant human cells extend over a range from 2 to 120 μm [ 12 ]. Collectively, the PVA/marjoram and PVA/marjoram/kaolin with pore sizes in the range of 21–34 μm could be encouraging sponge composites for further implementation as wound dressings.…”

Section: Resultsmentioning

confidence: 99%

“…Cell compatibility test of wound dressings is crucial in order to assess the extent to which the fabricated sponges possess favorable biocompatibility in response to prevalent dermal cells, such as fibroblast, keratinocyte, and epithelial cells. During wound recovery, fibroblasts play a pivotal role in the construction of connective tissues, giving rise to the granulation of skin tissues and promoting skin remodeling [ 12 , 27 , 57 ]. Given this fact, alongside the cell interactions with wound dressings, we performed cytotoxicity investigations on fibroblast cells by the MTT assay.…”

Section: Resultsmentioning

confidence: 99%

“…Injectable hydrogels have revealed good healing with hemostatic properties [ 10 ]; nevertheless, they typically have insufficient mechanical features, curtailing their implementation as hemostatic materials [ 11 ]. Furthermore, such injectable hydrogels might incite adverse complications for patients, aggravating the treated wound since it is painful either to change or remove them, particularly from profound injuries [ 12 ]. Thus, developing porous sponges with hemostatic, antibacterial, and antioxidant performances is advantageous because of their distinct three-dimensional structures, which enable them to have mechanical stability.…”

Section: Introductionmentioning

confidence: 99%

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Development of Polyvinyl Alcohol/Kaolin Sponges Stimulated by Marjoram as Hemostatic, Antibacterial, and Antioxidant Dressings for Wound Healing Promotion

Tamer

Alsehli

Omer

et al. 2021

IJMS

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The predominant impediments to cutaneous wound regeneration are hemorrhage and bacterial infections that lead to extensive inflammation with lethal impact. We thus developed a series of composite sponges based on polyvinyl alcohol (PVA) inspired by marjoram essential oil and kaolin (PVA/marjoram/kaolin), adopting a freeze–thaw method to treat irregular wounds by thwarting lethal bleeding and microbial infections. Microstructure analyses manifested three-dimensional interconnected porous structures for PVA/marjoram/kaolin. Additionally, upon increasing marjoram and kaolin concentrations, the pore diameters of the sponges significantly increased, recording a maximum of 34 ± 5.8 µm for PVA-M0.5-K0.1. Moreover, the porosity and degradation properties of PVA/marjoram/kaolin sponges were markedly enhanced compared with the PVA sponge with high swelling capacity. Furthermore, the PVA/marjoram/kaolin sponges exerted exceptional antibacterial performance against Escherichia coli and Bacillus cereus, along with remarkable antioxidant properties. Moreover, PVA/marjoram/kaolin sponges demonstrated significant thrombogenicity, developing high thrombus mass and hemocompatibility, in addition to their remarkable safety toward fibroblast cells. Notably, this is the first study to our knowledge investigating the effectiveness of marjoram in a polymeric carrier for prospective functioning as a wound dressing. Collectively, the findings suggest the prospective usage of the PVA-M0.5-K0.1 sponge in wound healing for hemorrhage and bacterial infection control.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development of Polyvinyl Alcohol/Kaolin Sponges Stimulated by Marjoram as Hemostatic, Antibacterial, and Antioxidant Dressings for Wound Healing Promotion

Tamer

Alsehli

Omer

et al. 2021

IJMS

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“…Porous and fibrous micro-structured scaffolds are newly emerging hemostatic agents during severe intraoperative or extra-operative bleeding as they can easily pressurize the interior of the tissue defect and be removed from the bleeding site ( Sultana et al, 2021 ). The ability of HFV70 to address noncompressible bleeding was evaluated in a rat liver defect model ( Figure 4E ).…”

Section: Resultsmentioning

confidence: 99%

Biocompatible and antibacterial Flammulina velutipes-based natural hybrid cryogel to treat noncompressible hemorrhages and skin defects

Zhu

Chen²,

Wu³

et al. 2022

Front. Bioeng. Biotechnol.

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Hemorrhage, infection, and frequent replacement of dressings bring great clinical challenges to wound healing. In this work, Flammulina velutipes extract (FV) and hydroxyethyl cellulose (HEC) were chemically cross-linked and freeze-dried to obtain novel HFV cryogels (named HFVn, with n = 10, 40, or 70 corresponding to the weight percentage of the FV content), which were constructed for wound hemostasis and full-thickness skin defect repair. Systematic characterization experiments were performed to assess the morphology, mechanical properties, hydrophilic properties, and degradation rate of the cryogels. The results indicated that HFV70 showed a loose interconnected-porous structure and exhibited the highest porosity (95%) and water uptake ratio (over 2,500%) with a desirable degradation rate and shape memory properties. In vitro cell culture and hemocompatibility experiments indicated that HFV70 showed improved cytocompatibility and hemocompatibility. It can effectively mimic the extracellular matrix microenvironment and support the adhesion and proliferation of L929 cells, and its hemolysis rate in vitro was less than 5%. Moreover, HFV70 effectively induced tube formation in HUVEC cells in vitro. The results of the bacteriostatic annulus confirmed that HFV70 significantly inhibited the growth of Gram-negative E. coli and Gram-positive S. aureus. In addition, HFV70 showed ideal antioxidant properties, with the DPPH scavenging rate in vitro reaching 74.55%. In vivo rat liver hemostasis experiments confirmed that HFV70 showed rapid and effective hemostasis, with effects comparable to those of commercial gelatin sponges. Furthermore, when applied to the repair of full-thickness skin defects in a rat model, HFV70 significantly promoted tissue regeneration. Histological analysis further confirmed the improved pro-angiogenic and anti-inflammatory activity of HFV70 in vivo. Collectively, our results demonstrated the potential of HFV70 in the treatment of full-thickness skin defects and rapid hemostasis.

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“…Chitosan is widely accepted as biomaterial for fabricating scaffolds due to its biodegradability, antibacterial effect, nontoxicity, and biocompatibility that arise due to the presence of primary amines in them [ 83 ]. Furthermore, it helps in stimulation of haemostasis and accelerates wound healing [ 84 , 85 ]. In addition, chitosan has also structural resemblance with glycosaminoglycans that helps in formation of ECM.…”

Section: Materials Used In Scaffold Fabricationmentioning

confidence: 99%

Recent Progress in Development of Dressings Used for Diabetic Wounds with Special Emphasis on Scaffolds

Awasthi

Gulati

Kumar

et al. 2022

BioMed Research International

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Diabetic wound (DW) is a secondary application of uncontrolled diabetes and affects about 42.2% of diabetics. If the disease is left untreated/uncontrolled, then it may further lead to amputation of organs. In recent years, huge research has been done in the area of wound dressing to have a better maintenance of DW. These include gauze, films, foams or, hydrocolloid-based dressings as well as polysaccharide- and polymer-based dressings. In recent years, scaffolds have played major role as biomaterial for wound dressing due to its tissue regeneration properties as well as fluid absorption capacity. These are three-dimensional polymeric structures formed from polymers that help in tissue rejuvenation. These offer a large surface area to volume ratio to allow cell adhesion and exudate absorbing capacity and antibacterial properties. They also offer a better retention as well as sustained release of drugs that are directly impregnated to the scaffolds or the ones that are loaded in nanocarriers that are impregnated onto scaffolds. The present review comprehensively describes the pathogenesis of DW, various dressings that are used so far for DW, the limitation of currently used wound dressings, role of scaffolds in topical delivery of drugs, materials used for scaffold fabrication, and application of various polymer-based scaffolds for treating DW.

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Multi-functional nanocellulose-chitosan dressing loaded with antibacterial lawsone for rapid hemostasis and cutaneous wound healing

Cited by 76 publications

References 53 publications

Development of Polyvinyl Alcohol/Kaolin Sponges Stimulated by Marjoram as Hemostatic, Antibacterial, and Antioxidant Dressings for Wound Healing Promotion

Development of Polyvinyl Alcohol/Kaolin Sponges Stimulated by Marjoram as Hemostatic, Antibacterial, and Antioxidant Dressings for Wound Healing Promotion

Biocompatible and antibacterial Flammulina velutipes-based natural hybrid cryogel to treat noncompressible hemorrhages and skin defects

Recent Progress in Development of Dressings Used for Diabetic Wounds with Special Emphasis on Scaffolds

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