Multi-immunometabolomics mining: NP prevents hyperimmune in ALI by inhibiting Leucine/PI3K/Akt/mTOR signaling pathway

Zhao, Mantong; Lin, Jiazi; Wang, Xiao; Chen, Chengkai; Li, Jianhua; Yu, Jiamin; Zhou, Tong; Liang, Yefang; Shen, Xuejuan; Shi, Ruixiang; Yang, Simin; Zeng, Shuting; Deng, Yongan; Duan, Xiaodong; Zhou, Lichang; Sun, Xiaobo; Wang, Yi; Shu, Zunpeng

doi:10.1016/j.freeradbiomed.2024.09.053

Free Radical Biology and Medicine

2024

DOI: 10.1016/j.freeradbiomed.2024.09.053

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Multi-immunometabolomics mining: NP prevents hyperimmune in ALI by inhibiting Leucine/PI3K/Akt/mTOR signaling pathway

Mantong Zhao,

Jiazi Lin,

Xiao Wang

et al.

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The impact of glucose metabolism on inflammatory processes in sepsis-induced acute lung injury

Cheng,

Li,

Sun

et al. 2024

Front. Immunol.

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Acute lung injury (ALI) is a prevalent and critical complication of sepsis, marked by high incidence and mortality rates, with its pathogenesis still not being fully elucidated. Recent research has revealed a significant correlation between the metabolic reprogramming of glucose and sepsis-associated ALI (S-ALI). Throughout the course of S-ALI, immune cells, including macrophages and dendritic cells, undergo metabolic shifts to accommodate the intricate demands of immune function that emerge as sepsis advances. Indeed, glucose metabolic reprogramming in S-ALI serves as a double-edged sword, fueling inflammatory immune responses in the initial stages and subsequently initiating anti-inflammatory responses as the disease evolves. In this review, we delineate the current research progress concerning the pathogenic mechanisms linked to glucose metabolic reprogramming in S-ALI, with a focus on the pertinent immune cells implicated. We encapsulate the impact of glucose metabolic reprogramming on the onset, progression, and prognosis of S-ALI. Ultimately, by examining key regulatory factors within metabolic intermediates and enzymes, We have identified potential therapeutic targets linked to metabolic reprogramming, striving to tackle the inherent challenges in diagnosing and treating Severe Acute Lung Injury (S-ALI) with greater efficacy.

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The impact of glucose metabolism on inflammatory processes in sepsis-induced acute lung injury

Cheng,

Li,

Sun

et al. 2024

Front. Immunol.

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show abstract

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Multi-immunometabolomics mining: NP prevents hyperimmune in ALI by inhibiting Leucine/PI3K/Akt/mTOR signaling pathway

Cited by 1 publication

References 45 publications

The impact of glucose metabolism on inflammatory processes in sepsis-induced acute lung injury

The impact of glucose metabolism on inflammatory processes in sepsis-induced acute lung injury

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