Multi-level Integrative Biomarker Responses in Freshwater Teleostean Fishes Exposed to Almix Herbicide

Samanta, Palas; Pal, Sandipan; Mukherjee, Asok K.; Senapati, Tarakeshwar; Jung, Jinho; Ghosh, Apurba Ratan

doi:10.1007/s41742-017-0042-2

Cited by 6 publications

(19 citation statements)

References 44 publications

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“…However, the time-dependent gradual reduction under long-term T1 and T2 exposures indicated that long-term naphthalene exposure adversely affects the fish health. Time-dependent reduced LYM counts recorded under this study was also defined in Oreochromis niloticus by Samanta et al …”

Section: Resultssupporting

confidence: 81%

“…testudineus under naphthalene exposure (both T1 and T2) was significantly reduced in comparison to the control condition (Table and S1). Reduced RBC level indicated that impaired erythropoies is due to lower oxygen carrying capacity, which helps to develop both anemia and hypoxic condition . Comparatively, higher reduction was observed in T2 dose than T1 (Table and S1), which indicated that higher dose caused more adverse impacts and reduced compensatory mechanism.…”

Section: Resultsmentioning

confidence: 95%

“…testudineus under T1 and T2 conditions gradually decreased significantly in comparison to the control condition (Table and S1). Reduction in Hb concentration indicated impaired supply of oxygen to different tissues, resulting in decreased metabolic function and reduced energy generation, which ultimately resulted in reduced adaptive responses to naphthalene intoxication . Additionally, lower Hb level promotes the development of anemia and hypoxic condition within fish .…”

Section: Resultsmentioning

confidence: 99%

“…testudineus under naphthalene exposure gradually decreased significantly in a time-dependent manner in comparison to the control condition (Table and S1). Reduced PCV was caused due to deformation of RBC and/or due to reduced RBC synthesis . In addition, this is because it is influenced both by the number of blood cells and their size .…”

Section: Resultsmentioning

confidence: 99%

“…A. testudineus was considered as a model organism because of its capability to provide early warning signal under both laboratory and field exposures of xenobiotics. , Additionally, it is widely distributed in natural environment, easily acclimated under laboratory environment, and has high commercial value as a protein source …”

Section: Introductionmentioning

confidence: 99%

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Time-Dependent Naphthalene Toxicity in Anabas testudineus (Bloch): A Multiple Endpoint Biomarker Approach

et al. 2020

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Polyaromatic compounds are the major, widespread contaminants in the aquatic environment. However, the adverse impacts of these compounds on blood pathophysiology (hematological profiling and serum biochemical responses) are poorly understood. As a consequence, this study was intended to evaluate the toxic effects of naphthalene, one of the polycyclic aromatic hydrocarbons, on the blood pathophysiology of Anabas testudineus using multiple end-point biomarker approach. A. testudineus was exposed to short-term (1 and 5 d) and long-term (10, 15, and 21 d) naphthalene concentrations, that is, T1 (0.71 mg/L indicates 25% of LC50) and T2 (1.42 mg/L indicates 50% of LC50 value). The results disclosed significant decrease in red blood cells, hemoglobin (Hb), packed cell volume, and platelet levels, while other blood parameters, namely, white blood cells, percent lymphocyte, mean cell volume, mean corpuscular Hb, and mean corpuscular Hb concentration showed enhanced levels under naphthalene intoxication. Results were more detrimental under T2 concentration. Cholesterol, glucose, calcium, high-density lipoprotein, and low-density lipoprotein levels gradually increased throughout the different exposure periods under T1 and T2 concentrations, while the triglyceride level gradually decreased during exposure periods. Finally, integrated biomarker responses (IBR) analysis indicated that serum biochemical parameters are more powerful than hematological parameters for determining the naphthalene-induced fish health status. Additionally, the IBR study clearly identified that long-term (>5 d) exposure was more harmful than short-term (<5 d) naphthalene exposure. So, these responses may be derived as biomarkers for monitoring naphthalene pollution in an aquatic ecosystem.

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Section: Resultssupporting

confidence: 81%

Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%