Multi-Level Plasticity-Pathology Continuum of the Nervous System: Functional Aspects

Gulyaeva, N. V.

doi:10.1134/s1819712422040092

Neurochem. J.

2022

DOI: 10.1134/s1819712422040092

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Multi-Level Plasticity-Pathology Continuum of the Nervous System: Functional Aspects

N. V. Gulyaeva

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Cited by 4 publications

References 24 publications

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Rethinking plasticity: Analysing the concept of “destructive plasticity” in the light of neuroscience definitions

Seblani,

Brezun,

Féron

et al. 2024

Eur J of Neuroscience

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As a multilevel and multidisciplinary field, neuroscience is designed to interact with various branches of natural and applied sciences as well as with humanities and philosophy. The continental tradition in philosophy, particularly over the past 20 years, tended to establish strong connections with biology and neuroscience findings. This cross fertilization can however be impeded by conceptual intricacies, such as those surrounding the concept of plasticity. The use of this concept has broadened as scientists applied it to explore an ever‐growing range of biological phenomena. Here, we examine the consequences of this ambiguity in an interdisciplinary context through the analysis of the concept of “destructive plasticity” in the philosophical writings of Catherine Malabou. The term “destructive plasticity” was coined by Malabou in 2009 to refer to all processes leading to psycho‐cognitive and emotional alterations following traumatic or nontraumatic brain injuries or resulting from neurodevelopmental disorders. By comparing it with the neuroscientific definitions of plasticity, we discuss the epistemological obstacles and possibilities related to the integration of this concept into neuroscience. Improving interdisciplinary exchanges requires an advanced and sophisticated manipulation of neurobiological concepts. These concepts are not only intended to guide research programmes within neuroscience but also to organize and frame the dialogue between different theoretical backgrounds.

show abstract

Rethinking plasticity: Analysing the concept of “destructive plasticity” in the light of neuroscience definitions

Seblani,

Brezun,

Féron

et al. 2024

Eur J of Neuroscience

View full text Add to dashboard Cite

show abstract

Glucocorticoids Orchestrate Adult Hippocampal Plasticity: Growth Points and Translational Aspects

Gulyaeva

2023

Biochemistry Moscow

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The review analyzes modern concepts about the control of various mechanisms of the hippocampal neuroplasticity in adult mammals and humans by glucocorticoids. Glucocorticoid hormones ensure the coordinated functioning of key components and mechanisms of hippocampal plasticity: neurogenesis, glutamatergic neurotransmission, microglia and astrocytes, systems of neurotrophic factors, neuroinflammation, proteases, metabolic hormones, neurosteroids. Regulatory mechanisms are diverse; along with the direct action of glucocorticoids through their receptors, there are conciliated glucocorticoid-dependent effects, as well as numerous interactions between various systems and components. Despite the fact that many connections in this complex regulatory scheme have not yet been established, the study of the factors and mechanisms considered in the work forms growth points in the field of glucocorticoid-regulated processes in the brain and primarily in the hippocampus. These studies are fundamentally important for the translation into the clinic and the potential treatment/prevention of common diseases of the emotional and cognitive spheres and respective comorbid conditions.

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An Intricated pas de deux of Addicted Brain and Body Is Orchestrated by Stress and Neuroplasticity

Gulyaeva,

Peregud

2024

Biochemistry Moscow

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Dependence on psychoactive substances is a phenomenon that is based on the alterations of common molecular and cellular mechanisms, structures and neuronal networks underlying normal brain functioning and realizing stress response, reinforcement and aversion, learning and memory. As a result, aberrant neuroplasticity states associated with somatic changes are formed, which determine the pathogenesis and symptoms of dependence and at the same time can be considered as targets for the development of therapies for such addictions. An integrative scheme of stress and neuroplastic changes participation in the formation of the vicious circle of substance use disorders based on a holistic approach is presented. This special issue of the journal focuses on the molecular mechanisms of psychoactive substance use disorders.

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Multi-Level Plasticity-Pathology Continuum of the Nervous System: Functional Aspects

Cited by 4 publications

References 24 publications

Rethinking plasticity: Analysing the concept of “destructive plasticity” in the light of neuroscience definitions

Rethinking plasticity: Analysing the concept of “destructive plasticity” in the light of neuroscience definitions

Glucocorticoids Orchestrate Adult Hippocampal Plasticity: Growth Points and Translational Aspects

An Intricated pas de deux of Addicted Brain and Body Is Orchestrated by Stress and Neuroplasticity

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