Multi-membrane hydrogel fabricated by facile dynamic self-assembly

Dai, Hongjun; Li, Xiaofeng; Long, Yuhua; Wu, Junjie; Liang, Songmiao; Zhang, Xiaoli; Zhao, Ning; Xu, Jingkun

doi:10.1039/b821363a

Cited by 208 publications

(84 citation statements)

References 23 publications

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“…The performance of the system as drug carriers was evaluated in vitro and showed a pulse-like drug release profi le. [ 158 ] Double-layer and triplelayer alginate particles can be prepared by a multi-fl uidic electrostatic spraying methodology with very high production rate and narrow distribution of sizes. [ 159 ] Besides that, replacing the inner compartment of the double-layer particles by an ECM compound (collagen), small intestinal organoids and tumor 3D microtissues were cultured successfully, showing that such compartmentalized systems could be very useful for development of effective 3D cell culture systems.…”

Section: Reviewmentioning

confidence: 99%

See 1 more Smart Citation

Design Advances in Particulate Systems for Biomedical Applications

Lima

Álvarez-Lorenzo

Mano

2016

Adv Healthcare Materials

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Particulate systems have been widely used as containers of drugs or cells with the purpose of releasing them in a particularThe search for more effi cient therapeutic strategies and diagnosis tools is a continuous challenge. Advances in understanding the biological mechanisms behind diseases and tissues regeneration have widened the fi eld of applications of particulate systems. Particles are no more just protective systems for the encapsulated drugs, but they play an active role in the success of the therapy. Moreover, particles have been explored for innovative purposes as templates for cells growth and as diagnostic tools. Until few years ago the most relevant parameters in particles formulation were the chemistry and the size. Currently, it is known that other physical characteristics can remarkably affect the performance of particulate systems. Particles with non-conventional shapes exhibit advantages due to the increasing circulation time in blood stream, less clearance by the immune system and more effi cient cell internalization and traffi cking. Creation of compartments has been found useful to control drug release, to tune the transport of substances across biological barriers, to supply the target with more than one bioactive agent or even to act as theranostic systems. It is expected that such complex shaped and compartmentalized systems improve the therapeutic outcomes and also the patient's compliance, acting as advanced devices that serve for simultaneous diagnosis and treatment of the disease, combining agents of very different features, at the same time. In this review, we overview and analyse the most recent advances in particle shape and compartmentalization and applications of newly designed particulate systems in the biomedical fi eld.

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Section: Reviewmentioning

confidence: 99%

“…A few in vitro results [ 127,128,157,158 ] demonstrated that core/shell and multilayered particles showed promising characteristics to be used as drug release systems and cell encapsulation. Regarding such encouraging preliminary results it is expected a translation for effective in vivo or even clinical studies in the next few years.…”

Section: Reviewmentioning

confidence: 99%

Design Advances in Particulate Systems for Biomedical Applications

Lima

Álvarez-Lorenzo

Mano

2016

Adv Healthcare Materials

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“…Ca 2+ ) [12][13][14]. The divalent cations can bind to the guluronate blocks of the alginate chains because the structure of the guluronate blocks enables a high degree of coordination with the divalent ions.…”

Section: Introductionmentioning

confidence: 99%

Cytocompatible and spontaneously forming phospholipid polymer hydrogels

Gao

Konno

Ishihara

2015

European Polymer Journal

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“…There has been a great deal of research activity in the development of stimulus-responsive membranes, especially in those with pH, temperature or ionic strength sensitivity [1][2][3][4][5][6]. Alginate is a pH sensitive and biocompatible natural hydrogel material with relatively low cost [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…Sodium palmitate is a non-toxic fatty acid sodium salt with an appropriate alkyl chain length ( (CH 2 ) 14 ), which can effectively inhibit water penetrating into the beads and decrease the water uptake. Biomineralized component (CaHPO 4 ) formed between Ca 2+ and HPO 4 2− and the polyelectrolyte formed between positively charged chitosan and negatively charged alginate exist in the resulting membranes. The diffusion-controlled deposition of inorganic minerals and hydrophobic component within porous organic polymeric matrices could prevent the permeation of the encapsulated drug and reduce the drug release effectively.…”

Section: Introductionmentioning

confidence: 99%