Multi-omic approach to evaluate the response of gilt-head sea bream (Sparus aurata) exposed to the UV filter sulisobenzone

Colás-Ruiz, Nieves R.; Ramirez, Gaëlle; Courant, Frédérique; Góméz, Elena; Hampel, Miriam; Lara-Martín, Pablo A.

doi:10.1016/j.scitotenv.2021.150080

Cited by 23 publications

(7 citation statements)

References 116 publications

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“…In environmental metabolomics, several authors focused on the identification of (potential) biomarkers in response to PhAC exposure. Our literature review revealed, however, that the main molecular effects highlighted in response to PhAC exposure and proposed as potential biomarkers (e.g., alterations in amino acid, nucleotide, and lipid and energy metabolism) were related to similar pathways that can be disturbed by other environmental contaminants (e.g., pesticides, polybrominated diphenyl ethers (PBDEs), polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), microplastics, heavy metals, and nanomaterials) [6,46,47] or environmental conditions [48,49]. It therefore may not be of interest to search for PhAC-specific biomarkers.…”

Section: Meoa Biomarkers To Enhance Environmental Biomonitoringmentioning

confidence: 99%

Environmental Metabolomics Promises and Achievements in the Field of Aquatic Ecotoxicology: Viewed through the Pharmaceutical Lens

et al. 2022

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Scientists often set ambitious targets using environmental metabolomics to address challenging ecotoxicological issues. This promising approach has a high potential to elucidate the mechanisms of action (MeOAs) of contaminants (in hazard assessments) and to develop biomarkers (in environmental biomonitoring). However, metabolomics fingerprints often involve a complex mixture of molecular effects that are hard to link to a specific MeOA (if detected in the analytical conditions used). Given these promises and limitations, here we propose an updated review on the achievements of this approach. Metabolomics-based studies conducted on the effects of pharmaceutical active compounds in aquatic organisms provide a relevant means to review the achievements of this approach, as prior knowledge about the MeOA of these molecules could help overcome some shortcomings. This review highlighted that current metabolomics advances have enabled more accurate MeOA assessment, especially when combined with other omics approaches. The combination of metabolomics with other measured biological endpoints has also turned out to be an efficient way to link molecular effects to (sub)-individual adverse outcomes, thereby paving the way to the construction of adverse outcome pathways (AOPs). Here, we also discuss the importance of determining MeOA as a key strategy in the identification of MeOA-specific biomarkers for biomonitoring. We have put forward some recommendations to take full advantage of environmental metabolomics and thus help fulfil these promises.

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Section: Meoa Biomarkers To Enhance Environmental Biomonitoringmentioning

confidence: 99%

Environmental Metabolomics Promises and Achievements in the Field of Aquatic Ecotoxicology: Viewed through the Pharmaceutical Lens

et al. 2022

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“…It absorbs ultraviolet radiations in both the UV-A and UV-B ranges (wavelength between 280 and 400 nm). 11 Apart from being a UV-filter, it has been shown to exhibit estrogen, antiestrogen, and antiandrogen activity in in vitro assays. 12 To increase the efficacy of the sunscreen, the formulation of a sunscreen requires the active chemical to penetrate less efficiently and to remain localized close to the skin surface for an extended period.…”

Section: Introductionmentioning

confidence: 99%

A combined experimental and theoretical study on p-sulfonatothiacalix[4]arene encapsulated sulisobenzone

et al. 2023

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“…Among BPs, benzophenone-3 (BP-3) and benzophenone-4 (BP-4) are the most frequently used and detected in environmental waters (Negreira et al 2009;Rodil et al 2012;De et al 2013;Li et al 2016). The effects of these UV-filters have been studied on different aquatic organisms, such as cyanobacteria, microalgae, clams, mussels, crustaceans, sea urchins, and fishes (Paredes et al 2014;Petersen et al 2014;Pablos et al 2015;Du et al 2017;Mao et al 2017;Seoane et al 2020;Yan et al 2022), and it has been reported that both compounds induce biochemical, physiological, endocrine and genetic alterations (Diaz-Cruz and Barcelo 2009;Zhang et al 2017;Meng et al 2020;Carstensen et al 2022;Colás-Ruiz et al 2022).…”

Section: Introductionmentioning

confidence: 99%

Analysis of the effects of BP-3 and BP-4 on the transcriptome of Chlamydomonas reinhardtii: An RNA-Seq approach

et al. 2023

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Benzophenones (BPs) are one of the most widely used UV-filters and previous flow cytometric studies have shown that these aquatic emerging pollutants alter the physiology of the freshwater microalga Chlamydomonas reinhardtii. In order to obtain a more detailed study of the different cellular metabolic pathways affected, changes caused by BPs in the transcriptome of C. reinhardtii were investigated using RNA-Seq analysis after 24 h of exposure. Each benzophenone at its corresponding 96 h-EC50 value for growth provoked alterations in the gene expression of this microalga, although BP-3-exposed cells showed a higher number of differentially expressed genes than cells exposed to BP-4. GO enrichment analyses suggested that both compounds affected the same cellular metabolic pathways. Transcripts encoding for light-harvesting and chlorophyll-binding proteins were highly reduced. In addition, an overexpression of genes related to amino acid catabolism was also detected, suggesting that C. reinhardtii cells oxidize amino acids to obtain energy when photosynthesis was damaged by the pollutants. Regarding the oxidative damage provoked by the contaminants, genes encoding main antioxidant enzymes and involved in glutathione-associated metabolism were upregulated. Moreover, sulphur metabolism could have some relevance to explain the mechanism of action of BP-4 and its lower toxicity on microalgae, since the sulfonic acid group is the major structural difference between both BPs. Obtained results suggest that photosynthesis was impaired on cells exposed to the UV-filters, leading microalgae to obtain energy via a heterotrophic metabolism to survive. Thus, the occurrence of these sunscreens in freshwater ecosystems could trigger a worrying reduction in global CO2 fixation.

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Multi-omic approach to evaluate the response of gilt-head sea bream (Sparus aurata) exposed to the UV filter sulisobenzone

Cited by 23 publications

References 116 publications

Environmental Metabolomics Promises and Achievements in the Field of Aquatic Ecotoxicology: Viewed through the Pharmaceutical Lens

Environmental Metabolomics Promises and Achievements in the Field of Aquatic Ecotoxicology: Viewed through the Pharmaceutical Lens

A combined experimental and theoretical study on p-sulfonatothiacalix[4]arene encapsulated sulisobenzone

Analysis of the effects of BP-3 and BP-4 on the transcriptome of Chlamydomonas reinhardtii: An RNA-Seq approach

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