Multi-omics and Mendelian Randomization network analysis of the association between metabolic and cognitive functions in the UK Biobank Database
Paolo Alberto Lorenzini,
Sarah R Langley
Abstract:In obese individuals, low levels of leptin, an hormone regulating energy expenditure, have been claimed to be associated with neurodegeneration during ageing. Since leptin signalling system is less potent in the elderly, its protective anti-inflammatory effect in the brain is inhibited and people overweight in middle-age are at higher risk of developing dementia later in life. However, the causal association between obesity and cognitive decline has been inconsistent so far. We incorporated several metabolic a… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.