2024
DOI: 10.1101/2024.05.30.24307732
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Multi-omics and Mendelian Randomization network analysis of the association between metabolic and cognitive functions in the UK Biobank Database

Paolo Alberto Lorenzini,
Sarah R Langley

Abstract: In obese individuals, low levels of leptin, an hormone regulating energy expenditure, have been claimed to be associated with neurodegeneration during ageing. Since leptin signalling system is less potent in the elderly, its protective anti-inflammatory effect in the brain is inhibited and people overweight in middle-age are at higher risk of developing dementia later in life. However, the causal association between obesity and cognitive decline has been inconsistent so far. We incorporated several metabolic a… Show more

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