Multi-omics approaches establishing histone modification based prognostic model in glioma patients and further verification of the carcinogenesis mechanism

Wang, Yunhui; Ji, LiKang; Ji, Chunfeng; Wang, Fan

doi:10.1007/s10142-023-01229-3

Funct Integr Genomics

2023

DOI: 10.1007/s10142-023-01229-3

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Multi-omics approaches establishing histone modification based prognostic model in glioma patients and further verification of the carcinogenesis mechanism

Yunhui Wang,

LiKang Ji,

Chunfeng Ji

et al.

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2024

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TMEM205 induces TAM/M2 polarization to promote cisplatin resistance in gastric cancer

Fu,

Wu,

et al. 2024

Gastric Cancer

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Cisplatin (DDP) is a basic chemotherapy drug for gastric cancer (GC). With the increase of DDP drug concentration in clinical treatment, cancer cells gradually became resistant. Therefore, it is necessary to find effective therapeutic targets to enhance the sensitivity of GC to DDP. Studies have shown that Transmembrane protein 205 (TMEM205) is overexpressed in DDP-resistant human epidermoid carcinoma cells and correlates with drug resistance, and database analyses show that TMEM 205 is also overexpressed in GC, but its role in cisplatin-resistant gastric cancer remains unclear. In this study, we chose a variety of experiments in vivo and vitro, aiming to investigate the role of TMEM 205 in cisplatin resistance in gastric cancer. The results showed that TMEM 205 promoted proliferation, stemness, epithelial–mesenchymal transition (EMT), migration and angiogenesis of gastric cancer cells through activation of the Wnt/β-catenin signaling pathway. In addition, TMEM205 promotes GC progression by inducing M2 polarization of tumor-associated macrophages (TAMs). These results suggest that TMEM205 may be an effective target to regulate the sensitivity of GC to DDP, providing a new therapeutic direction for clinical treatment.

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TMEM205 induces TAM/M2 polarization to promote cisplatin resistance in gastric cancer

Fu,

Wu,

et al. 2024

Gastric Cancer

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Multi-omics approaches establishing histone modification based prognostic model in glioma patients and further verification of the carcinogenesis mechanism

Cited by 1 publication

References 36 publications

TMEM205 induces TAM/M2 polarization to promote cisplatin resistance in gastric cancer

TMEM205 induces TAM/M2 polarization to promote cisplatin resistance in gastric cancer

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