Multi-omics data reveals the disturbance of glycerophospholipid metabolism caused by disordered gut microbiota in depressed mice

Tian, Tian; Mao, Qiang; Xie, Jing; Wang, Ying; Shao, Wei; Zhong, Qi; Chen, Jianjun

doi:10.1016/j.jare.2021.10.002

Cited by 60 publications

(45 citation statements)

References 54 publications

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“…Previous study reported that the changes of short-chain fatty acids (SCFAs) caused by the disordered Firmicutes might account for the physiological basis of the decreased levels of inflammation in MDD patients ( Huang et al., 2018 ). Using animal model of depression, we found that gut microbiota might contribute to the occurrence of depressive-like behaviors by affecting the levels of SCFAs and neurotransmitters ( Wu et al., 2020 ); further investigation showed that ‘‘Firmicutes-SCFAs-GP metabolism-Tryptophan pathway” could be a potential pathway between gut microbiota and brain functions ( Tian et al., 2021 ). Here, we observed that the majority of differential OTUs belonged to Firmicutes.…”

Section: Discussionmentioning

confidence: 99%

Gut Microbiota-Related Inflammation Factors as a Potential Biomarker for Diagnosing Major Depressive Disorder

Bai

et al. 2022

Front. Cell. Infect. Microbiol.

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ObjectiveAlthough many works have been done, the objectively measured diagnostic biomarkers are not available. Thus, we conducted this study to identify potential biomarkers for objectively diagnosing depression and explore the role of gut microbiota in the onset of depression.MethodsMajor depressive disorder (MDD) patients (n=56) and demographic data-matched healthy controls (HCs) (n=56) were included in this study. The gut microbiota in fecal samples and inflammation-related factors in serum were measured. Both univariate and multivariate statistical analyses were performed to identify the differential gut microbiota and inflammation-related factors.ResultsFinally, 46 differential operational taxonomic units (OTUs) (60.9% OTUs belonging to Firmicutes) and ten differential inflammation-related factors were identified. Correlation analysis showed that there were significant correlations between 14 differential OTUs (9 OTUs belonging to Firmicutes and 5 OTUs belonging to family Lachnospiraceae under Firmicutes) and seven differential inflammation-related factors. Meanwhile, 14 differential OTUs (9 OTUs belonging to Firmicutes and 5 OTUs belonging to family Lachnospiraceae under Firmicutes) and five differential inflammation-related factors (adiponectin, apolipoprotein A1, alpha 1-antitrypsin, neutrophilicgranulocyte count/white blood cell count and basophil count) were significantly correlated to depression severity. A panel consisting of these five differential inflammation-related factors could effectively diagnose MDD patients from HCs.ConclusionsOur results suggested that Firmicutes, especially family Lachnospiraceae, might play a role in the onset of depression via affecting the inflammation levels of host, and these five differential inflammation-related factors could be potential biomarkers for objectively diagnosing MDD.

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Section: Discussionmentioning

confidence: 99%

Gut Microbiota-Related Inflammation Factors as a Potential Biomarker for Diagnosing Major Depressive Disorder

Bai

et al. 2022

Front. Cell. Infect. Microbiol.

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“…Two of these neurotransmitters (norepinephrine and serotonin) were also significantly decreased here in the prefrontal cortex of DM. In another study, we found that four neurotransmitters (tryptophan, serotonin, indolelactic acid, and 5-hydroxyindoleacetic acid) were significantly decreased in the hippocampus of CRS-induced DM ( Tian et al., 2021 ). Interestingly, the significant decreases of tryptophan and serotonin were also observed here in the prefrontal cortex of DM.…”

Section: Discussionmentioning

confidence: 93%

“…Many pieces of evidence demonstrated that the disturbance of neurotransmitters could be the hallmark of depression ( Milak et al., 2016 ; Zheng et al., 2016 ; Oh et al., 2020 ; Afzal et al., 2021 ). Our group found that a panel consisting of four plasma neurotransmitters could effectively diagnose patients with depression from healthy controls ( Pan et al., 2018 ), and we also observed the disturbance of neurotransmitters in the hippocampus and hypothalamus of DM ( Pan et al., 2019 ; Wang et al., 2020 ; Wu et al., 2020 ; Tian et al., 2021 ). Growing pieces of evidence suggested that there were close relationships between gut microbiota and neurotransmitters ( Chen et al., 2021 ; Huang and Wu, 2021 ; Wang et al., 2021 ).…”

Section: Introductionmentioning

confidence: 79%

“…Studies have reported that the onset and development of many diseases, such as autism and diabetes, have a close relationship with the disturbance of gut microbiota ( Khoshkam et al., 2021 ; Li et al., 2021 ; Medici Dualib et al., 2021 ; Xu et al., 2021 ). In our previous studies, we found that there were significant differences on the gut microbiota compositions in both patients with depression and depressed mice (DM) compared with their respective healthy controls ( Zheng et al., 2016 ; Wu et al., 2020 ; Bai et al., 2021 ; Tian et al., 2021 ). Other researchers also reported the similar results ( Naseribafrouei et al., 2014 ; Jiang et al., 2015 ).…”

Section: Introductionmentioning

confidence: 99%

“…Growing pieces of evidence suggested that there were close relationships between gut microbiota and neurotransmitters ( Chen et al., 2021 ; Huang and Wu, 2021 ; Wang et al., 2021 ). Using chronic restraint stress (CRS)–induced depression model, we found the close relationships between disordered microbial metabolites and changed neurotransmitters in the hippocampus and hypothalamus of DM ( Wu et al., 2020 ; Tian et al., 2021 ). These findings indicated that neurotransmitters might be the bridge between microbial metabolites and depression.…”

Section: Introductionmentioning

confidence: 99%

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Associations Between Disordered Microbial Metabolites and Changes of Neurotransmitters in Depressed Mice

Xie

Wang

Zhong

et al. 2022

Front. Cell. Infect. Microbiol.

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BackgroundsMany pieces of evidence demonstrated that there were close relationships between gut microbiota and depression. However, the specific molecular mechanisms were still unknown. Here, using targeted metabolomics, this study was conducted to explore the relationships between microbial metabolites in feces and neurotransmitters in prefrontal cortex of depressed mice.MethodsChronic unpredictable mild stress (CUMS) model of depression was built in this study. Targeted liquid chromatography–mass spectrometry analysis was used to detect the microbial metabolites in feces and neurotransmitters in prefrontal cortex of mice. Both univariate and multivariate statistical analyses were applied to identify the differential microbial metabolites and neurotransmitters and explore relationships between them.ResultsNinety-eight differential microbial metabolites (mainly belonged to amino acids, fatty acids, and bile acids) and 11 differential neurotransmitters (belonged to tryptophan pathway, GABAergic pathway, and catecholaminergic pathway) were identified. Five affected amino acid–related metabolic pathways were found in depressed mice. The 19 differential microbial metabolites and 10 differential neurotransmitters were found to be significantly correlated with depressive-like behaviors. The two differential neurotransmitters (tyrosine and glutamate) and differential microbial metabolites belonged to amino acids had greater contributions to the overall correlations between microbial metabolites and neurotransmitters. In addition, the significantly decreased L-tyrosine as microbial metabolites and tyrosine as neurotransmitter had the significantly positive correlation (r = 0.681, p = 0.0009).ConclusionsThese results indicated that CUMS-induced disturbances of microbial metabolites (especially amino acids) might affect the levels of neurotransmitters in prefrontal cortex and then caused the onset of depression. Our findings could broaden the understanding of how gut microbiota was involved in the onset of depression.

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Evaluation of gut microbiota composition to screening for potential biomarker in AFB1-exposed sheep

Lin,

Fu,

Zhang

et al. 2023

3 Biotech

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Multi-omics data reveals the disturbance of glycerophospholipid metabolism caused by disordered gut microbiota in depressed mice

Cited by 60 publications

References 54 publications

Gut Microbiota-Related Inflammation Factors as a Potential Biomarker for Diagnosing Major Depressive Disorder

Gut Microbiota-Related Inflammation Factors as a Potential Biomarker for Diagnosing Major Depressive Disorder

Associations Between Disordered Microbial Metabolites and Changes of Neurotransmitters in Depressed Mice

Evaluation of gut microbiota composition to screening for potential biomarker in AFB1-exposed sheep

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