Multi‐Organ Spread and Intra‐Host Diversity of SARS‐CoV‐2 Support Viral Persistence, Adaptation, and a Mechanism That Increases Evolvability
Julieta M. Manrique,
Santiago Maffia‐Bizzozero,
M. Victoria Delpino
et al.
Abstract:Intra‐host diversity is an intricate phenomenon related to immune evasion, antiviral resistance, and evolutionary leaps along transmission chains. SARS‐CoV‐2 intra‐host variation has been well‐evidenced from respiratory samples. However, data on systemic dissemination and diversification are relatively scarce and come from immunologically impaired patients. Here, the presence and variability of SARS‐CoV‐2 were assessed among 71 tissue samples obtained from multiple organs including lung, intestine, heart, kidn… Show more
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