Multi-slit prompt-gamma camera for locating of distal dose falloff in proton therapy

Park, Jong Hoon; Kim, Sung Hun; Ku, Youngmo; Kim, Chan Hyeong; Lee, Han Rim; Jeong, Jee–Heon; Lee, Se Byeong; Shin, Dong Ho

doi:10.1016/j.net.2019.03.008

Cited by 17 publications

(9 citation statements)

References 20 publications

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“…A similar collimated setup was built and tested experimentally by Park et al [37]. The geometry of both the collimator (coarser pattern) and the detector (finer granulation) was somewhat different than in case of [35].…”

Section: Multi-slit Camera (Mps)mentioning

confidence: 99%

Range Verification by Means of Prompt-Gamma Detection in Particle Therapy 1

Wrońska¹,

Dauvergne²

2021

Radiation Detection Systems

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Ion range verification in particle therapy, possibly in real time, is still an open issue to improve the treatment quality by reducing safety margins. Among the various methods that are under study or already brought to the clinics, prompt gamma offer a unique opportunity of real time control. In this chapter, we present the physical background and conditions specific for the operation environment in the clinics, followed by an overview of the various techniques relying on prompt-gamma detection that have been proposed and developed for more than a decade. Different approaches, based on imaging and non-imaging techniques, providing either integrated or differential information are described, and their maturity, limitations and clinical usefulness are discussed.

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Section: Multi-slit Camera (Mps)mentioning

confidence: 99%

Range Verification by Means of Prompt-Gamma Detection in Particle Therapy 1

Wrońska¹,

Dauvergne²

2021

Radiation Detection Systems

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“…This value is confronted with precision values reported by other groups working with different setups (both simulation and experimental) in table 2. In the comparison, we include besides our results also those obtained with a two-dimensional coded mask setup (Sun et al 2020a), multi-parallel slit (MPS) simulation (Pinto et al 2014) and experimental (Park et al 2019) results as well as clinical results obtained with knife-edge slit (KES) design (Richter et al 2016, Xie et al 2017. Although precision-wise our results outperform most of the works under comparison, we admit that our simulation model does not take into account certain effects which could deteriorate the result, e.g.…”

Section: Discussionmentioning

confidence: 99%

“…Not only do they register more gamma quanta than single-slit cameras, but they offer also a larger field of view (FOV). The performance of multi-slit setups was studied extensively via GEANT4 simulations for different geometrical configurations in Pinto et al (2014), and experimentally in Park et al (2019). However, no superiority with respect to the knife-edge-shaped camera could be shown.…”

Section: Introductionmentioning

confidence: 99%

Near-field coded-mask technique and its potential for proton therapy monitoring

Hetzel,

Urbanevych,

Bolke

et al. 2023

Phys. Med. Biol.

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Objective. Prompt-gamma imaging encompasses several approaches to the online monitoring of the beam range or deposited dose distribution in proton therapy. We test one of the imaging techniques – a coded mask approach – both experimentally and via simulations.Approach. Two imaging setups have been investigated experimentally. Each of them comprised a structured tungsten collimator in the form of a MURA mask and a LYSO:Ce scintillation detector of fine granularity. The setups differed in detector dimensions and operation mode (1D or 2D imaging). A series of measurements with radioactive sources have been conducted, testing the performance of the setups for near-field gamma imaging. Additionally, Monte Carlo simulations of a larger setup of the same type were conducted, investigating its performance with a realistic gamma source distribution occurring during proton therapy.Main results. The images of point-like sources reconstructed from two small-scale prototypes’ data using the MLEM algorithm constitute the experimental proof of principle for the near-field coded-mask imaging modality, both in the 1D and the 2D mode. Their precision allowed us to calibrate out certain systematic offsets appearing due to the limited alignment accuracy of setup elements. The simulation of the full-scale setup yielded a mean distal falloff retrieval precision of 0.72 mm in the studies for beam energy range 89.5–107.9 MeV and with 1 × 108 protons (a typical number for distal spots). The implemented algorithm of image reconstruction is relatively fast - a typical procedure needs several seconds.Significance. Coded-mask imaging appears a valid option for proton therapy monitoring. The results of simulations let us conclude that the proposed full-scale setup is competitive with the knife-edge-shaped and the multi-parallel slit cameras investigated by other groups.

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“…Some imaging devices have been proposed in the past to monitor the proton range in vivo , which are modified versions of classical nuclear medicine imaging modalities 4 – 10 , while other more original approaches do not provide the full PG profile (e.g. prompt gamma spectroscopy 11 , PG integral counts 12 , 13 ).…”

Section: Introductionmentioning

confidence: 99%

A high sensitivity Cherenkov detector for prompt gamma timing and time imaging

Jacquet

Ansari

Gallin-Martel

et al. 2023

Sci Rep

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We recently proposed a new approach for the real-time monitoring of particle therapy treatments with the goal of achieving high sensitivities on the particle range measurement already at limited counting statistics. This method extends the Prompt Gamma (PG) timing technique to obtain the PG vertex distribution from the exclusive measurement of particle Time-Of-Flight (TOF). It was previously shown, through Monte Carlo simulation, that an original data reconstruction algorithm (Prompt Gamma Time Imaging) allows to combine the response of multiple detectors placed around the target. The sensitivity of this technique depends on both the system time resolution and the beam intensity. At reduced intensities (Single Proton Regime—SPR), a millimetric proton range sensitivity can be achieved, provided the overall PG plus proton TOF can be measured with a 235 ps (FWHM) time resolution. At nominal beam intensities, a sensitivity of a few mm can still be obtained by increasing the number of incident protons included in the monitoring procedure. In this work we focus on the experimental feasibility of PGTI in SPR through the development of a multi-channel, Cherenkov-based PG detector with a targeted time resolution of 235 ps (FWHM): the TOF Imaging ARrAy (TIARA). Since PG emission is a rare phenomenon, TIARA design is led by the concomitant optimisation of its detection efficiency and Signal to Noise Ratio (SNR). The PG module that we developed is composed of a small PbF$$_{2}$$ 2 crystal coupled to a silicon photoMultiplier to provide the time stamp of the PG. This module is currently read in time coincidence with a diamond-based beam monitor placed upstream the target/patient to measure the proton time of arrival. TIARA will be eventually composed of 30 identical modules uniformly arranged around the target. The absence of a collimation system and the use of Cherenkov radiators are both crucial to increase the detection efficiency and the SNR, respectively. A first prototype of the TIARA block detector was tested with 63 MeV protons delivered from a cyclotron: a time resolution of 276 ps (FWHM) was obtained, resulting in a proton range sensitivity of 4 mm at 2$$\sigma$$ σ with the acquisition of only 600 PGs. A second prototype was also evaluated with 148 MeV protons delivered from a synchro-cyclotron obtaining a time resolution below 167 ps (FWHM) for the gamma detector. Moreover, using two identical PG modules, it was shown that a uniform sensitivity on the PG profiles would be achievable by combining the response of gamma detectors uniformly distributed around the target. This work provides the experimental proof-of-concept for the development of a high sensitivity detector that can be used to monitor particle therapy treatments and potentially act in real-time if the irradiation does not comply to treatment plan.

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Multi-slit prompt-gamma camera for locating of distal dose falloff in proton therapy

Cited by 17 publications

References 20 publications

Range Verification by Means of Prompt-Gamma Detection in Particle Therapy 1

Range Verification by Means of Prompt-Gamma Detection in Particle Therapy 1

Near-field coded-mask technique and its potential for proton therapy monitoring

A high sensitivity Cherenkov detector for prompt gamma timing and time imaging

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