Multi-Target-Directed Cinnamic Acid Hybrids Targeting Alzheimer’s Disease

Abstract

Progressive cognitive decline in Alzheimer’s disease (AD) is a growing challenge. Present therapies are based on acetylcholinesterase inhibition providing only temporary relief. Promising alternatives include butyrylcholinesterase (BuChE) inhibitors, multi-target ligands (MTDLs) that address the multi-factorial nature of AD, and compounds that target oxidative stress and inflammation. Cinnamate derivatives, known for their neuroprotective properties, show potential when combined with established AD agents, demonstrating improved efficacy. They are being positioned as potential AD therapeutic leads due to their ability to inhibit Aβ accumulation and provide neuroprotection. This article highlights the remarkable potential of cinnamic acid as a basic structure that is easily adaptable and combinable to different active groups in the struggle against Alzheimer’s disease. Compounds with a methoxy substitution at the para-position of cinnamic acid display increased efficacy, whereas electron-withdrawing groups are generally more effective. The effect of the molecular volume is worthy of further investigation.

Coordinative Compounds Based on Unsaturated Carboxylate with Versatile Biological Applications

“…Cinnamic acid and its derivatives are encountered in plants and are reported due to their antibacterial, antifungal, anticancer, antiparasitic properties, and potential therapeutic behavior against Alzheimers' disease [45,46]. Given these attributes, it was expected that cinnamate-based complexes would exhibit similar properties, and so the literature was accordingly scanned to identify such complexes.…”