Multi-trait genome-wide analysis identified novel risk loci and candidate drugs for heart failure
Zhengyang Yu,
Maohuan Lin,
Zhanyu Liang
et al.
Abstract:Heart failure (HF) is a common cardiovascular disease that poses significant morbidity and mortality risks. While genome-wide association studies reporting on HF abound, its genetic etiology is not well understood due to its inherent polygenic nature. Moreover, these genetic insights have not been completely translated into effective strategies for the primary treatment of HF. In this study, we conducted a large-scale integrated multi-trait analysis using European-ancestry GWAS summary statistics of coronary a… Show more
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