Multi Wavelengths Fusion Profiling for Quality Evaluation of Donglingcao Tablets Combined with Electrochemical Oscillation Fingerprints and Antioxidant Activity Analysis

Abstract

For a long time, Donglingcao tablets (DLCT) has been considered as a valuable traditional Chinese medicine (TCM) preparation. The five-wavelength fusion fingerprints (FWFFP) of 16 batches of DLCT, which avoided fluctuation of single wavelength evaluation, were established to analyze fingerprint similarity by ratio fingerprint quantitative method (RFQM). Furthermore, electrochemical oscillation fingerprints (ECOFP) of DLCT from different manufacturers were studied by Belousov Zhabotinskii (B-Z) oscillating system at con-stant temperature. In addition, intrinsic characteristics of DLCT from different manufacturers were determined by chemometric methods, and they can well distinguish samples of each manufacturer. Meanwhile, partial least squares (PLS) model was built to predict antioxidant activity of DLCT and to correlate with components in the fingerprint, which proved significant contribution of peaks 16-rosmarinic acid and 19-oridonin. The combination of FWFFP with antioxidant and ECOFP provided a new idea for identification and analysis of DLCT.

Evaluating the quality consistency of antiviral oral liquid by high-performance liquid chromatography five-wavelength matched average fusion fingerprint combined with electrochemical fingerprint and ultraviolet spectral quantum fingerprint

“…2F , the evaluation results for the same sample at five wavelengths differed, making the quality assessment using a single wavelength somewhat biased. FMAFFP synthesized the fingerprint data at each wavelength, resulting in more precise and comprehensive evaluation results [35] . The modest variation range of S L suggested that the chemical compositions of samples were distributed similarly.…”

Evaluating the consistency of rice and paddy quality using four-dimensional fingerprint analysis

“…15 Three experiments were linearized using quantum fingerprinting and quantization is a digitization assignment process, which is a digitization of continuous signals, full-value informatization, and original chromatographic transformation of the original signal completeness. 16 In addition, using a B-Z electrochemical oscillation system, 17 electrochemistry is an analytical technique based on the phenomenon of chemical oscillations. When different substances are added to a system, the chemical substances contained in it will participate in an oscillatory reaction, causing the damped oscillations to eventually stop for a finite period of time, 18 and the shape of the curve and information on the specific parameters can reflect the differences in the samples, and thus can be used for identification or quality evaluation.…”

“…In addition, using a B–Z electrochemical oscillation system, 17 electrochemistry is an analytical technique based on the phenomenon of chemical oscillations. When different substances are added to a system, the chemical substances contained in it will participate in an oscillatory reaction, causing the damped oscillations to eventually stop for a finite period of time, 18 and the shape of the curve and information on the specific parameters can reflect the differences in the samples, and thus can be used for identification or quality evaluation.…”