Multicenter case-control study of risk factors associated with development of vaccine-associated sarcomas in cats

Kass, Philip H.; Spangler, W. L.; Hendrick, Mattie J.; McGill, Lawrence D.; Esplin, D. G.; Lester, Sally; Slater, Margaret R.; Meyer, E; Boucher, Faith; Peters, Erika M.; Gobar, Glenna; Htoo, Thurein M.; Decile, Kendra C.

doi:10.2460/javma.2003.223.1283

Cited by 111 publications

(134 citation statements)

References 6 publications

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“…Vaccinations and injections have been found to lead to sarcomas in cats (Kass et al 2003), dogs (Vascellari et al 2003), and ferrets (Munday et al 2003). In humans, there are a number of reports of pacemaker implantation site malignancy that have involved both sarcomas and carcinomas (Bhandarkar et al 1993;Biran et al 1979;Carpentier et al 2000;Fraedrich et al 1984;Okamoto et al 2010), and similarly, one of 104 dogs with pacemaker implantation is reported to have developed fibrosarcoma at the pacemaker generator site, thirty months after implantation (Johnson et al 2007).…”

Section: Resultsmentioning

confidence: 99%

Peritoneal Sarcomatosis Associated with Telemetry Implants in Sprague Dawley CD Rats

et al. 2011

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Surgical implantation of radiotelemetric transmitters is a current practice to collect a variety of physiological parameters in unrestrained laboratory animals, and in rodents in particular. In this study, the incidence of peritoneal sarcomatosis arising secondary to surgically implanted telemetry devices (< 15% of implanted Sprague Dawley rats) is considered to represent a significant issue for both animal welfare and data validity in affected animals. Macroscopically, the telemetry-associated fibrosarcomas spread along the visceral and parietal peritoneum and mesentery surrounding abdominal organs. The histologic morphology of these sarcomas was typically an undifferentiated sarcoma, although well-differentiated fibrosarcomas and telangiectatic and pleomorphic variants were noted. Using special stains such as Masson's Trichrome demonstrated a collagenous extracellular matrix in 50% of these rats, which is consistent with a fibroblastic origin. Immunohistochemical studies clearly delineated the mesenchymal components of the sarcomas (fibroblasts and smooth muscle cells); one case, however, was diagnosed as an osteosarcoma.

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Section: Resultsmentioning

confidence: 99%

Peritoneal Sarcomatosis Associated with Telemetry Implants in Sprague Dawley CD Rats

et al. 2011

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“…Στόχος είναι η διευκόλυνση της χειρουργικής αφαί ρεσης πιθανού μετεμβολιακού σαρκώματος. Και οι δύο επιστημονικοί φορείς συνιστούν την αποφυγή έγχυσης των εμβολίων στο ακρώμιο (δύσκολη έως αδύνατη η χειρουργική εξαίρεση των σαρκωμάτων) και τη χορήγηση του κάθε εμβολίου σε διαφορετικό σημείο (στον ίδιο ή σε διαφορετικό χρόνο), για να μειωθεί η πιθανότητα εμφάνισης σαρκώματος (Kass et al 2003).…”

Section: σε ποιο σημείο και πώς πρέπει να γίνονται τα εμβό λια στη γάτα;unclassified

New vaccination protocols for the dog and cat: the challenge of today for a better and safer prevention

Mylonakis

Koutinas

Saridomichelakis

et al. 2017

J Hellenic Vet Med Soc

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Vaccinations are an integral part of a comprehensive preventive health care program targeting to minimize the incidence of major canine and feline infectious diseases. Currently, vaccination practices are re-evaluated globally towards a twofold objective: to strengthen "herd immunity", which depends on the percentage of vaccinated animals in a population, and to reduce the "vaccine load" per animal in order to minimize the vaccine-associated adverse reactions. To this end, the updated canine and feline vaccination guidelines, encourage the vaccination of as many animals as possible, while at the same time classify the vaccines into core, non-core and not recommended. Core vaccines should be administered, if possible, to every dog and cat.Canine parvovirus-2, canine adenovirus-2, canine distemper virus, feline parvovirus, feline calicivirus/herpesvirus-1 and rabies vaccines fall into this category. Non-core vaccines are selectively given to dogs and cats after assessing the risk/benefit ratio. There are also vaccines for which there is currently no sufficient scientific evidence to justify their use. Importantly, after the one-year booster inoculation that follows the completion of the initial puppy/kitten vaccination series, core vaccines should be given no more frequently than every three years, as the duration of the protective immunity far exceeds this time interval. This review focuses on the updated canine and feline vaccination guidelines pertaining to the individual animal as well as to those living in groups. Important questions related to vaccination programs and to relevant adverse reactions are also answered. An effort has been made to align these guidelines according to what is considered a "norm" among the small amimal practitioners in Greece.

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“…Both vaccine types contain aluminum as adjuvant [3,4] that is capable to trigger a chronic infl ammation (i.e., granulomatous reaction) at the site of vaccination [4,5]. However, some reports demonstrated no signifi cant difference in the incidence of sarcomas with regard to vaccines with or without adjuvant materials [4,6]. The prevalence of FISS in vaccinated subjects range from 1/1.000 to 1/10.000 [7,8].…”

Section: Introductionmentioning

confidence: 99%

“…FISS are regularly occurring in 10 years old subjects (average age), with some peaks in 6-7 and 10-11 years old cats, respectively. A slightly higher incidence was noticed in females compared to males; no breed predisposition was observed [4,6,9,10].…”

Section: Introductionmentioning

confidence: 99%

Description of a Feline Injection-Site Fibrosarcoma with Metastasis in the Cerebellum

et al. 2017

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Feline injection-site sarcomas were initially described by Hendrick and Goldschmidt (1991). The link between vaccination site and sarcoma occurrence suggested the term of vaccine-associated sarcomas. Our paper describes an unusual feline injection-site fi brosarcoma with cerebellar metastasis. A 7-year-old female domestic short-hair cat was submitted to the Pathology Department (Faculty of Veterinary Medicine ClujNapoca, Romania) for necropsy. A subcutaneous tumor (relapse) in the interscapular region and multiple metastatic masses in the lungs, kidneys, subcutaneous tissue (scapular and thigh regions) and cerebellum were observed. Cytological, histological and immunohistochemical (for vimentin, desmin, multi-cytokeratin, α-smooth muscle actin, S100 and CD45) analyses from all tumors were performed. Cytological examination identifi ed highly pleomorphic spindle-shaped cells admixed with neoplastic multinucleated giant cells. Histologically, all neoplastic masses were composed of numerous spindle cells arranged into interlacing bundles. Extensive intratumoral areas of necrosis along with a neutrophilic infi ltrate were also detected. A fi brillary material was present among neoplastic cells (green stained by Masson's trichrome method), suggesting a collagenous structure. In all tumors assessed, immunohistochemistry showed an intense reaction only for vimentin in numerous neoplastic cells. Based on the history, gross, cytological, histological and immunohistochemical data, the fi nal diagnosis was recurrent feline injection-site fi brosarcoma, with multiple metastases (including in the cerebellum). Overall, an uncommon case of feline injection-site fi brosarcoma has been reported. This is the fi rst consistent record of an injection site sarcoma in a cat with cerebellar metastasis.

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Multicenter case-control study of risk factors associated with development of vaccine-associated sarcomas in cats

Cited by 111 publications

References 6 publications

Peritoneal Sarcomatosis Associated with Telemetry Implants in Sprague Dawley CD Rats

Peritoneal Sarcomatosis Associated with Telemetry Implants in Sprague Dawley CD Rats

New vaccination protocols for the dog and cat: the challenge of today for a better and safer prevention

Description of a Feline Injection-Site Fibrosarcoma with Metastasis in the Cerebellum

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