Multicenter case-control study of the risk factors for ulcerative colitis in China

Wang, Yufang; Ouyang, Qi; Xia, Bing; Liu, Lina; Gu, Fang; Zhou, Kai-Fang; Qiao, Mingqi; Shi, Ruihua; Ran, Zhihua; Wang, Xiaodi; Hu, Pinjin; Wu, Kaichun; Liu, Xinguang; Miao, Yi; Han, Ying; Wu, Xiaoping; He, Guo-Bing; Zhong, Jie; Liu, Guanjian

doi:10.3748/wjg.v19.i11.1827

Cited by 59 publications

(51 citation statements)

References 27 publications

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“…The present study identified a significant probability of low fruit and high refined sugar intake to be associated with UC similar to other (including Asian) studies [9][10][11][12][13] . The possible mechanism of protection is by antioxidant vitamins and fibres contained in these foods.…”

Section: Discussionsupporting

confidence: 75%

Association of Dietary Factors With Ulcerative Colitis in India

Ray¹

2015

Journal of Gastroenterology and Hepatology Research

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AIM:Western studies associate high intake of fat, animal protein, refined sugars and low intake of fruits and green vegetables with causation of ulcerative colitis. Indian data on such association is scanty. METHODS: 50 consecutive patients of ulcerative colitis were compared to 50 age and sex matched normal controls with respect to their demographic and nutritional parameters (based on commonly consumed food items in the region) in this prospective case control study. Food groups enquired for were meat, fish, cereals, fruits, green leafy vegetables, fried foods, refined sugar and tea/coffee and their intake was estimated semiquantitatively by a questionairre. Univariate and multivariate analysis of the parameters was carried out to detect the association of any with ulcerative colitis at significance level p < 0.05. RESULTS: Low intake of fruits (odds ratio 0.28 for the lowest intake level) and high intake of refined sugar (odds ratio 1.78 for the highest intake level) were the only significant factors associated with occurrence of ulcerative colitis on both univariate and multivariate analysis. None of the patients were pure vegetarians. CONCLUSION: This initial study showed association of ulcerative colitis with similar food items in India as in the West despite vast difference in dietary practices.

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Section: Discussionsupporting

confidence: 75%

Association of Dietary Factors With Ulcerative Colitis in India

Ray¹

2015

Journal of Gastroenterology and Hepatology Research

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“…Comparison I was conducted among 11 studies (5)(6)(7)19,25,27,28,(30)(31)(32)34) with 10,889 subjects (UC patients: 4,673; healthy control: 6,216). …”

Section: The Results Of Comparison I: Appendectomy Was a Protective Fmentioning

confidence: 99%

“…Then, 321 completely unrelated studies and 140 reviews, letters or abstracts were excluded, and 45 articles remained. By screening of the full text, 19 studies were finally included in the present meta-analysis (5)(6)(7)(15)(16)(17)19,(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34). The basic information of the selected studies is listed in tables I-III.…”

Section: Study Selectionmentioning

confidence: 99%

Meta-analysis of the association between appendiceal orifice inflammation and appendectomy and ulcerative colitis

Deng

Wu²

2016

Rev Esp Enferm Dig

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Objective: This study aimed to investigate the relationship between appendiceal orifice inflammation (AOI) and appendectomy and ulcerative colitis (UC) by a meta-analysis.Methods: Databases were thoroughly searched for studies on AOI and UC up to January 2016. Three comparisons were performed: a) whether the previous appendectomy was a risk factor of UC; b) influence of appendectomy on UC courses; c) influence of AOI on UC severity. Odds ratios (ORs) and 95% confidence intervals (CIs) were the effects sizes. The merging of results and publication bias assessment were performed by using RevMan 5.3. Sensitivity analysis was conducted using Stata 12.0.Results: Nineteen studies were selected in the present study. Conclusion: In conclusion, this meta-analysis indicated appendectomy can reduce the risk of UC. But appendectomy or AOI had no influence on the severity of the disease and the effect of surgical treatment.

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“…The characteristics of the final nine studies selected for analysis are shown in Table 1 (15)(16)(17)(18)(19)(20)(21)(22)(23). Two cohort and seven case-control studies were included.…”

Section: Literature Review and Study Characteristicsmentioning

confidence: 99%

“…The nine studies reported a total of 2,019 cases of UC, 683 of CD, and 160 of IBD. Data was obtained from Asian (n=4) (15)(16)(17)21) and European (n=5) populations (18-20, 22, 23). Of the nine studies, five examined total meat consumption (15-17,19,21,23), three only examined red meat consumption (18,20,22), two examined processed meat consumption (22,23), and two only examined white meat consumption (18,20).…”

Section: Literature Review and Study Characteristicsmentioning

confidence: 99%

Meat intake and risk of inflammatory bowel disease: A meta-analysis

Han²,

Liu³

et al. 2020

Turk J Gastroenterol

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Background/Aims: This meta-analysis is designed to determine the association between meat consumption and the risk of inflammatory bowel disease. Materials and Methods: Search relevant literature published in PubMed, Cochrane before July 2015 without restrictions. Studies were included if relative ratios and the corresponding 95% confidence intervals of the risk of inflammatory bowel disease were reported with respect to meat consumption. Results: Nine studies were included in this meta-analysis. Relative to those who did not or seldom eat meat, meat consumers had a significantly greater risk of inflammatory bowel disease (pooled relative ratio: 1.50, 95% confidence interval: 1.15-1.95). The funnel plot revealed no evidence for publication bias. Conclusion: Meat consumption may increase the risk of inflammatory bowel disease. Additional large prospective studies are warranted to verify this association.

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Multicenter case-control study of the risk factors for ulcerative colitis in China

Abstract: Our study showed tap water consumption was a protective factor for UC, while spicy food, heavy sugar consumption and often feeling stress were risk factors for UC in this Chinese population.

Cited by 59 publications

References 27 publications

Association of Dietary Factors With Ulcerative Colitis in India

Association of Dietary Factors With Ulcerative Colitis in India

Meta-analysis of the association between appendiceal orifice inflammation and appendectomy and ulcerative colitis

Meat intake and risk of inflammatory bowel disease: A meta-analysis

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