2009
DOI: 10.1093/annonc/mdp045
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Multicenter phase II trial of preoperative induction chemotherapy followed by chemoradiation with docetaxel and cisplatin for locally advanced esophageal carcinoma (SAKK 75/02)

Abstract: This neoadjuvant, taxane-containing regimen was efficacious and feasible in patients with locally advanced esophageal cancer in a multicenter, community-based setting and represents a suitable backbone for further investigation.

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Cited by 72 publications
(63 citation statements)
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“…Toxicities from these new combinations are acceptable and early results are promising. Induction docetaxel/cisplatin followed by the same regimen with radiation and then surgery reported a pCR (or near) rate of 47%, with survival data similar to other phase II studies [Ruhstaller et al 2009;Schuller et al 2008].…”
Section: Neo-adjuvant Chemoradiotherapysupporting
confidence: 80%
“…Toxicities from these new combinations are acceptable and early results are promising. Induction docetaxel/cisplatin followed by the same regimen with radiation and then surgery reported a pCR (or near) rate of 47%, with survival data similar to other phase II studies [Ruhstaller et al 2009;Schuller et al 2008].…”
Section: Neo-adjuvant Chemoradiotherapysupporting
confidence: 80%
“…[147][148][149][150][151][152][153][154][155][156][157][158][159][160][161][162][163] In a recent phase I/II study, preoperative chemoradiation with a three drug regimen comprising of docetaxel, oxaliplatin, and capecitabine was safe and effective in patients with locoregional disease. 164 At a median follow-up of 116 weeks, median disease-free and overall survivals were 16 and 24 months, respectively.…”
Section: Preoperative Chemoradiation Therapymentioning
confidence: 99%
“…PET imaging was performed as part of a prospective multi-center phase II trial investigating a cisplatin-and taxane-based regimen of 2 cycles of inductionchemotherapy,followedbyCRTandsurgery(SwissGroupfor ClinicalCancerResearch,SAKK75/02,NCT00072033) [17].Theprotocol wasapprovedbythelocalethicscommitteesoftheparticipatingcenters. ThestudypopulationconsistedofpreviouslyuntreatedpatientswithhistologicallyconfirmedlocallyadvancedbutresectableSCCandadenocarcinomaofthethoracicesophagusoresophagogastricjunctionclassifiedasclinicalstageT3N0,T1-3N+orT4Nx,accordingtotheAJCCCancerStaging Manual, 6th edition [18].…”
Section: Patientsmentioning
confidence: 99%