Multicenter Study of 19 Aortopulmonary Window Parathyroid Tumors: The Challenge of Embryologic Origin

Arnault, Vincent; Beaulieu, Anthony; Lifante, Jean-Christophe; Serra, Antonio; Sébag, F.; Mathonnet, Muriel; Hamy, A.; Meurisse, Michel; Carnaille, B.; Kraimps, J. L.

doi:10.1007/s00268-010-0622-1

Cited by 37 publications

(32 citation statements)

References 34 publications

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“…Ektopik paratiroid dokusu embriyolojik göç yoluna bağlı olarak sıklıkla üçüncü veya dördüncü faringeal poş ile ilişkili yapılarda ortaya çıkmaktadır. Nadiren paratiroid adenomu anormal göç yoluna bağlı olarak farklı lokalizasyonlardaki paratiroid dokusundan da gelişebilmektedir 6 .…”

Section: Discussionunclassified

Intrathyroidal Parathyroid Adenoma: A Case Report and Review of The Literature

Sözen¹,

Yitik²,

Sakalli³

et al. 2015

Sakarya Med J

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ÖzetTek paratiroid adenomu primer hiperparatiroidinin (PHT) en sık sebebi olup, intratiroidal paratiroid adenomu nadir görülen bir durumdur. Ektopik paratiroid glandları baskın olarak timus, retroözofageal bölge ve tiroid içinde yerleşim göstermektedir. Primer hiperparatiroidinin kesin tedavisi paratiroidektomidir. Bu olgu nedeniyle intratroidal yerleşimli ektopik paratiroid adenomlarında cerrahi seçenekleri ve postoperatif takibi literatür bilgileri ışığında gözden geçirildi.

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Section: Discussionunclassified

Intrathyroidal Parathyroid Adenoma: A Case Report and Review of The Literature

Sözen¹,

Yitik²,

Sakalli³

et al. 2015

Sakarya Med J

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“…Other causes include a previously unnoticed multiglandular disease (multiple adenomas or hyperplasia) or a missed abnormal orthotopic gland (5,10,29).…”

Section: Persistent Phptmentioning

confidence: 99%

“…The incidence of ectopic parathyroid glands in patients with PHPT ranges from 9% to 20% (2,5,12,29). Superior parathyroid glands (together with the lateral thyroid) arise from the fourth pharyngeal pouch.…”

Section: Ectopic Parathyroid Glandsmentioning

confidence: 99%

“…Considering inferior glands, the ectopic sites would be intrathymic, anterosuperior mediastinum, intrathyroidal, thyrothymic ligament, and submandibular area. Rarely, ectopic parathyroid glands may be located at the aortopulmonary window, pericardium, hypopharynx (pyriform sinus), nasopharynx, vagus nerve sheath (arising from the fourth pharyngeal arch, near the third and fourth pharyngeal pouches) or posterior cervical triangle (2,5,10,12,13,29,30).…”

Section: Ectopic Parathyroid Glandsmentioning

confidence: 99%

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Persistent primary hyperparathyroidism: an uncommon location for an ectopic gland - Case report and review

Gouveia

Rodrigues

Barros

et al. 2012

Arq Bras Endocrinol Metab

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SUMMARYPrimary hyperparathyroidism (PHPT) is a common endocrine disorder that mainly affects middleaged women. Patients are usually asymptomatic. The disease might be ascribable to hyperplasia, carcinoma, and single or multiple adenomas. PHPT may be sporadic or familial, the latter comprising multiple endocrine neoplasia type 1 or 2A, familial benign hypocalciuria hypercalcemia, and hyperparathyroidism-jaw tumor syndrome. The most common causes for persistent PHPT are multiglandular disease, and missed abnormal ectopic or orthotopic parathyroid glands. Ima ging localization studies should precede a new surgical intervention. Ectopic parathyroid glands are rarely located at the aortopulmonary window. For diagnosis confirmation, Tc-sestamibi SPECT/CT seems to be an advantageous test. Another possibility is to perform 99m Tc-sestamibi followed by thoracic CT or MRI. Parathyroidectomy may be performed by means of median sternotomy, thoracotomy, or video-assisted thoracoscopy. We describe a case of persistent primary hyperparathyroidism due to the presence of an ectopic parathyroid gland found at the aortopulmonary window. As the investigation necessary to clarify the etiology of recurrent nephrolithiasis proceeded, the diagnosis of PHPT was determined. The patient underwent subtotal parathyroi dectomy; nevertheless, PHPT persisted. Genetic syndromes that could account for this condition were excluded. Imaging studies available at that time were not able to locate abnormal glands; moreover, the patient refused to undergo surgical exploration. Later, the patient underwent 99m Tc-sestamibi SPECT/CT, which revealed a parathyroid gland at the aortopulmonary window. Arq Bras Endocrinol Metab. 2012;56(6):393-403 SUMÁRIO O hiperparatiroidismo primário (HPP) é uma endocrinopatia frequente que afeta maioritariamente mulheres de meia-idade e é geralmente assintomática. A doença pode ser atribuível a hiperplasia, carcinoma, adenomas únicos ou múltiplos. O HPP inclui formas esporádicas e familiares. As formas familiares englobam neoplasia endócrina múltipla tipo 1 ou 2A, hipercalcemia hipocalciúrica familiar e síndrome hiperparatiroidismo/tumor mandibular-maxilar. As causas mais frequentes de HPP persistente são a presença de doença multiglandular ou de paratiroide anômala ectópica ou ortotópica não identificada previamente. É recomendável que a localização imagiológica preceda a reintervenção cirúrgica. A janela aortopulmonar é uma localização ectópica rara, sendo o 99m Tcsestamibi SPECT/TC um exame de confirmação vantajoso ou, alternativamente o 99m Tc-sestamibi seguido de TC ou RM torácica. A paratiroidectomia pode ser efetuada por meio de esternotomia mediana, toracotomia ou toracoscopia videoassistida. Descrevemos um caso de HPP persistente atribuível à presença de uma glândula paratiroide ectópica localizada à janela aortopulmonar. O diagnóstico de HPP foi estabelecido na sequência da investigação requisitada para esclarecimento etiológico da nefrolitíase recidivante constatada nessa doente. Foi submetida à paratiroidec...

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“…A venous thromboembolism with resulting PE triggers an inflammatory reaction characterized by cytokine and/or chemokine increase and inflammatory cell flow in the pulmonary arterial wall 6 . In this context, biochemical and hematological markers of systemic embolism may also be used for prognosis in PE.…”

Section: Introductionmentioning

confidence: 99%

The Prognostic Value of The Platelet/Lymphocyte Ratio in Predicting Short-Term Mortality in Patients with Acute Pulmonary Embolism

Şener¹,

Sivri²,

Sivri³

et al. 2015

Sakarya Med J

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Objectıves: Pulmonary embolism (PE), which has an inflammatory component, has high mortality and morbidity rates. The platelet/lymphocyte ratio is a novel marker of inflammation that is an independent predictor of mortality in cardiac and various oncological diseases. The aim of the present study was to determine the prognostic value of the platelet/lymphocyte ratio for short-term mortality for patients with acute pulmonary embolism. Materials and Methods:A total of 290 patients who were admitted to the emergency department and diagnosed with acute PE were enrolled retrospectively. Acute pulmonary embolism was confirmed via multislice computerized tomography. Results ÖzetAmaç Pulmoner emboli yüksek mortalite ve morbidite oranları ile inflamatuvar bileşeni iyi bilinen bir hastalıktır. Platelet / lenfosit oranı, kalp ve çeşitli onkolojik hastalıklarda mortalitenin bağımsız belirleyicisi olan inflamasyonun yeni bir belirtecidir. Bu çalışmanın amacı, akut pulmoner emboli hastalarında kısa süreli mortalite için platelet / lenfosit oranının prognostik değerini belirlemektir.Materyal ve Metot: Acil servise başvuran ve akut PE tanısı toplam 290 hasta çalışmaya retrospektif olarak alındı . Akut pulmoner emboli çok kesitli bilgisayarlı tomografi ile teyit edildi.Bulgular: Pulmoner emboli tanısı alan 290 hastanın, tanı aldıktan sonra 53'ü (%18,2) 1 ay içinde öldü. Yaş, malignite, koroner arter hastalığı, sağ ventrikül dilatasyonu, hemoglobin beyaz kan hücresi nötrofil ve trombosit sayımları sistolik pulmoner arter basıncı nötrofil / lenfosit oranı platelet / lenfosit oranı ve pulmoner emboli ciddiyet indeksi grup 1'de grup 2'ye göre anlamlı derecede yüksek bulundu. Platelet / lenfosit oranının 176.31 ve üzerinde olması akut pulmoner emboli sonrası 30 günlük mortaliteyi predikte ettirmedeki duyarlılığı %79 ve özgüllüğü %70'ti. Platelet / lenfosit oranı, hemoglobin ve basitleştirilmiş pulmoner emboli ciddiyet indeksi, akut pulmoner emboli tanısı almış hastalarda mortalitenin bağımsız bir belirleyicisiydi.Sonuç: Platelet / lenfosit oranı, pulmoner emboli sonrası erken dönemde mortalite gelişen hastalarda, mortalite gelişmeyenlere göre daha yüksekti. Bu sebeple, platelet / lenfosit oranı gibi ucuz ve pratik bir parametre akut pulmoner embolide mortalite risk tahmininde kullanılabilir.

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Multicenter Study of 19 Aortopulmonary Window Parathyroid Tumors: The Challenge of Embryologic Origin

Cited by 37 publications

References 34 publications

Intrathyroidal Parathyroid Adenoma: A Case Report and Review of The Literature

Intrathyroidal Parathyroid Adenoma: A Case Report and Review of The Literature

Persistent primary hyperparathyroidism: an uncommon location for an ectopic gland - Case report and review

The Prognostic Value of The Platelet/Lymphocyte Ratio in Predicting Short-Term Mortality in Patients with Acute Pulmonary Embolism

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