Multicenter study of environmental contamination with cyclophosphamide, ifosfamide, and methotrexate in 66 Canadian hospitals: A 2016 follow-up study

Roland, Christel; Caron, Nicolas; Bussières, Jean-François

doi:10.1080/15459624.2017.1316389

Cited by 29 publications

(27 citation statements)

References 9 publications

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“…With a constant value of 20 µg spilled per predetermined area, an average of 15.57 ± 13.99 pg/cm 2 . The average decontamination efficacy for disposable mops was 99.58% ± 0.28 % and 99.86% ± 0.09 % for non-disposable mops.…”

Section: Resultsmentioning

confidence: 99%

“…Each side of each wipe was used twice to sample a surface: once horizontally and once vertically. The sampling technique, was developed by the Institut National de Santé Publique du Québec and was used previsouly [2]. Sampling wipes were stored between 2-8°C in 50-mL polypropylene tubes.…”

Section: Description Of the Studymentioning

confidence: 99%

“…Results were expressed in ng/mL and converted to ng/ cm 2 . Final results were expressed in pg/cm 2 .…”

Section: Description Of the Studymentioning

confidence: 99%

“…The National Institute for Occupational Safety and Health (NIOSH) estimated that around 8 million U.S. healthcare workers were potentially exposed to hazardous drugs [1]. All work surfaces in hospital pharmacy and patient care units can potentially be contaminated [2].…”

Section: Introductionmentioning

confidence: 99%

“…In a Canadian surveillance program that is conducted since 2008, participants sometimes indicated their concern with HD traces that were still measured on some surfaces despite regular thorough cleaning conducted by sanitation workers [2].…”

Section: Introductionmentioning

confidence: 99%

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Pilot Study Evaluating the Efficacy of Four Cleaning Solutions and Two Types of Mops in Delimited Areas of a Floor Contaminated with Cyclophosphamide

Roland

Adé

Ouellette-Frève

et al. 2017

Pharmaceutical Technology in Hospital Pharmacy

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AbstractBackgroundHazardous drugs (HD) traces are measured in most hospitals that perform environmental surveillance. Uncertainties exist regarding the cleaning agents and procedures needed to completely remove HD contamination The objective was to evaluate the efficacy of four cleaning solutions and two types of mops in reducing contamination on a floor contaminated with a predetermined amount of cyclophosphamide (CP).MethodsThis pilot study was divided into three steps: 1) the voluntary contamination of a pre-delimited area on the floor (3600cmResultsThe average decontamination efficacy of the four cleaning products used was: 99.53%±0.41 % for the detergent, 99.74%±0.15 % for quaternary ammonium, 99.86%±0.11 % for sodium hypochlorite, 99.75%±0.15 %, for hydrogen peroxide. The average decontamination efficacy for disposable mops was 99.58%±0.28 % and 99.86%±0.09 % for non-disposable mops.ConclusionSodium hypochlorite, hydrogen peroxide, quaternary ammonium and a detergent applied with a disposable or a non-disposable mop were efficient to reduce the CP concentration on the floor contaminated with a predetermined quantity of CP. However, no cleaning scenarios was able to remove 100 % of CP after one cleaning session. Further studies are required to identify an optimal strategy.

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Section: Resultsmentioning

confidence: 99%

Section: Description Of the Studymentioning

confidence: 99%

“…Results were expressed in ng/mL and converted to ng/ cm 2 . Final results were expressed in pg/cm 2 .…”

Section: Description Of the Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Pilot Study Evaluating the Efficacy of Four Cleaning Solutions and Two Types of Mops in Delimited Areas of a Floor Contaminated with Cyclophosphamide

Roland

Adé

Ouellette-Frève

et al. 2017

Pharmaceutical Technology in Hospital Pharmacy

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Occupational Toxicology in the Pharmaceutical Industry

Dolan

Bercu

Graham³

et al. 2023

Patty's Toxicology

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Much of the activity in the pharmaceutical industry has its origins in the fine chemicals industry of the late nineteenth century. At that time, advances in chemistry and medicine led to the manufacture of pharmacologically active small molecules to produce desirable biological effects to treat diseases and illnesses at relatively low doses. Advances in biology and chemistry in the past quarter century have led to an increase in innovation resulting in a variety of novel modalities, especially recombinant proteins, antibody‐drug conjugates, cell and gene therapies, peptides and polypeptides, oligonucleotides, and vaccines. The roles and responsibilities of occupational toxicologists in the pharmaceutical industry have expanded dramatically in the twenty‐first century, commensurate with the changing regulatory requirements and treatment modalities. The occupational toxicologists' roles have become increasingly multidisciplinary and the scope of their involvement has expanded to encompass diverse aspects of worker safety as well as patient safety, and to include involvement throughout a molecule's development, from early development through postcommercialization.

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Closed-system drug-transfer devices plus safe handling of hazardous drugs versus safe handling alone for reducing exposure to infusional hazardous drugs in healthcare staff

Gurusamy

Best

Tanguay

et al. 2018

Cochrane Database of Systematic Reviews

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There is currently no evidence to support or refute the routine use of closed-system drug transfer devices in addition to safe handling of infusional hazardous drugs, as there is no evidence of differences in exposure or financial benefits between CSTD plus safe handling versus safe handling alone (very low-quality evidence). None of the studies report health benefits.Well-designed multicentre randomised controlled trials may be feasible depending upon the proportion of people with exposure. The next best study design is interrupted time-series. This design is likely to provide a better estimate than uncontrolled before-after studies or cross-sectional studies. Future studies may involve other alternate ways of reducing exposure in addition to safe handling as one intervention group in a multi-arm parallel design or factorial design trial. Future studies should have designs that decrease the risk of bias and enable measurement of direct health benefits in addition to exposure. Studies using exposure should be tested for a relevant selection of hazardous drugs used in the hospital to provide an estimate of the exposure and health benefits of using CSTD. Steps should be undertaken to ensure that there are no other differences between CSTD and control groups, so that one can obtain a reasonable estimate of the health benefits of using CSTD.

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Multicenter study of environmental contamination with cyclophosphamide, ifosfamide, and methotrexate in 66 Canadian hospitals: A 2016 follow-up study

Cited by 29 publications

References 9 publications

Pilot Study Evaluating the Efficacy of Four Cleaning Solutions and Two Types of Mops in Delimited Areas of a Floor Contaminated with Cyclophosphamide

Pilot Study Evaluating the Efficacy of Four Cleaning Solutions and Two Types of Mops in Delimited Areas of a Floor Contaminated with Cyclophosphamide

Occupational Toxicology in the Pharmaceutical Industry

Closed-system drug-transfer devices plus safe handling of hazardous drugs versus safe handling alone for reducing exposure to infusional hazardous drugs in healthcare staff

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