Multicentre research: lessons from the field

Willock, Jane; Askew, Carolyn; Bolland, Rachael; Maciver, Hannah; James, Neal

doi:10.7748/paed.17.10.31.s23

Cited by 9 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the rehabilitation care setting, chronically ill as well as physically handicapped children are treated. Immobility and reduced sensation has been previously defined as a major risk factor in the study of Willock et al. (2005).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The prevalence of pressure ulcers in four paediatric institutions

Schlüer

Cignacco

Müller

et al. 2009

Journal of Clinical Nursing

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…Further potential risk factors mentioned are immobility and decreased skin sensitivity (Suddaby et al. 2005, Willock 2005, Willock et al. 2005).…”

Section: Introductionmentioning

confidence: 99%

The prevalence of pressure ulcers in four paediatric institutions

Schlüer

Cignacco

Müller

et al. 2009

Journal of Clinical Nursing

View full text Add to dashboard Cite

show abstract

“…3 Several studies have found that PU is also a common problem in pediatrics population. 4 The prevalence of childhood hospital ulcers varies from 3% to 35%. 5 In pediatrics population, the risk factors for the formation of known ulcers include immobility and decreased skin sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Microbial Patterns and Antimicrobial Susceptibility on Pediatric Patients with Pressure Ulcers

Paramita

Nasution

Lubis

2019

Mol Cell Biomed Sci

View full text Add to dashboard Cite

Background: A pressure ulcer (PU) is localized injury to the skin and/or underlying tissue usually over a bony prominence, as a result of pressure, or pressure in combination with sharp surface. Several studies have found that PU is also a common problem in the pediatric population. Infection at PU sites is the most common complication, where PU can host resistant microorganisms and can turn into a local infection that is a source of bacteremia in hospital patients. This study aims to determine the most common bacteria and antimicrobial susceptibility at the site of PU in pediatric patients that serve as baseline data in Haji Adam Malik Hospital.Materials and Methods: A cross-sectional study was carried out in July-December 2017, involving 30 PU pediatric patients. For each subject, swab from ulcers were cultured in microbial laboratory to determine the microbial pattern and antimicrobial susceptibility.Results: The most common age group was 0-3 (53.3%), the highest gender was male (60%), the most common type was type 2 (46.7%), the main location was occipital (30%) and the most common undelying diseases were hydrocephalus (16.6%). The most common microbial pattern in PU pediatric patients is Acinetobacter baumannii (40%). The highest sensitivity is vancomycine for gram positive bacteria and amikacine for gram negative bacteria.Conclusion: The most common microbial pattern in PU pediatric patients in Haji Adam Malik Hospital is Acinetobacter baumannii (40%). The highest sensitivity is vancomycine for gram positive bacteria and amikacine for gram negative bacteria.Keywords: pressure ulcer, pediatric, microbial pattern, antimicrobial susceptibility

show abstract

“…[1][2][3][4][5] Challenges of multi-centred studies have been documented to include high financial cost, difficulty maintaining scientific integrity and logistical problems (e.g. the requirement of multiple ethics and research governance submissions).…”

mentioning

confidence: 99%

“…Multi-centred trials are becoming increasingly common in health research as they allow researchers to gather large sample sizes that enable increased statistical power, more timely recruitment, clinically meaningful research, and enable generalisability of results. [1][2][3][4][5] Challenges of multi-centred studies have been documented to include high financial cost, difficulty maintaining scientific integrity and logistical problems (e.g. the requirement of multiple ethics and research governance submissions).…”

mentioning

confidence: 99%

Conducting a paediatric multi‐centre RCT with an industry partner: Challenges and lessons learned

Maskell¹,

Newcombe²,

Martin³

et al. 2012

J Paediatrics Child Health

View full text Add to dashboard Cite

There are many benefits of multi-centred research including large sample sizes, statistical power, timely recruitment and generalisability of results. However, there are numerous considerations when planning and implementing a multi-centred study. This article reviews the challenges and successes of planning and implementing a multi-centred prospective randomised control trial involving an industry partner. The research investigated the impact on psychosocial functioning of a cosmetic camouflage product for children and adolescents with burn scarring. Multi-centred studies commonly have many stakeholders. Within this study, six Australian and New Zealand paediatric burn units as well as an industry partner were involved. The inclusion of an industry partner added complexities as they brought different priorities and expectations to the research. Further, multifaceted ethical and institutional approval processes needed to be negotiated. The challenges, successes, lessons learned and recommendations from this study regarding Australian and New Zealand ethics and research governance approval processes, collaboration with industry partners and the management of differing expectations will be outlined. Recommendations for future multi-centred research with industry partners include provision of regular written reports for the industry partner; continual monitoring and prompt resolution of concerns; basic research practices education for industry partners; minimisation of industry partner contact with participants; clear roles and responsibilities of all stakeholders and utilisation of single ethical review if available.

show abstract

Multicentre research: lessons from the field

Cited by 9 publications

References 0 publications

The prevalence of pressure ulcers in four paediatric institutions

The prevalence of pressure ulcers in four paediatric institutions

Microbial Patterns and Antimicrobial Susceptibility on Pediatric Patients with Pressure Ulcers

Conducting a paediatric multi‐centre RCT with an industry partner: Challenges and lessons learned

Contact Info

Product

Resources

About